Precipitated sdLDL: An easy method to estimate LDL particle size

Fernández-Cidón, Barbara; Candás-Estébanez, Beatriz; Ribalta, Josep; Rock, Edmond; Guardiola, Montse; Amigó, Núria; Padró-Miquel, Ariadna; Alía-Ramos, Pedro; Sala, Xavier Pintó

doi:10.1002/jcla.23282

Cited by 10 publications

(9 citation statements)

References 30 publications

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“…Relevant studies have shown that the determination of sdLDL‐C is helpful in risk assessment and the determination of cardiovascular residual risk. 46 Recent studies have shown that some diseases including obesity, 44 , 45 metabolic syndrome (MetS), 45 , 47 , 48 systemic hypertension, 49 and hepatic diseases 50 , 51 are associated with high sdLDL‐C concentrations. Moreover, the sdLDL‐C/LDL‐C ratio has been used as an alternative risk indicator in some comorbidities associated with the cardiovascular system.…”

Section: Discussionmentioning

confidence: 99%

Serum concentrations of small dense low‐density lipoprotein cholesterol and lipoprotein(a) are related to coronary arteriostenosis in Takayasu arteritis

Chen

Luan

et al. 2021

Clinical Laboratory Analysis

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Background: Serum small dense low-density lipoprotein cholesterol (sdLDL-C) and lipoprotein(a) [Lp(a)] levels are related to coronary disease, but their specific associations with coronary arteriostenosis in Takayasu arteritis (TA) have not been ascertained. This study explored the correlations between serum sdLDL-C and Lp(a) levels and coronary arteriostenosis in TA patients as well as the degree of artery stenosis.Methods: This retrospective study included 190 TA patients and 154 healthy subjects. TA patients were divided into three categories based on the degree of coronary stenosis: Group I, stenosis >50%; Group II, stenosis 1%-50%; and Group III, stenosis 0%. Independent risk factors for coronary arteriostenosis in TA were identified by logistic regression, followed by receiver operating characteristic curve analysis to determine the specificity and sensitivity of risk factors and Youden's Index score calculation to determine the cutoff points.Results: Takayasu arteritis patients had significantly higher serum levels of sdLDL-C and Lp(a) than healthy controls (p < 0.0001). The total cholesterol, triglyceride, LDL-C, sdLDL-C, and Lp(a) levels and the sdLDL-C/LDL-C ratio in Group I were significantly higher than those in Groups II and III (p < 0.05). An elevated serum sdLDL-C level elevated the risk of coronary arteriostenosis by 5-fold (cutoff value, 0.605 mmol/l).An increased serum Lp(a) level increased the risk of coronary arteriostenosis by 3.9fold (cutoff value, 0.045 g/l). An elevated sdLDL-C/LDL-C ratio increased the risk of coronary arteriostenosis by 2.1-fold (cutoff value, 0.258). Conclusions: Serum sdLDL-C and Lp(a) levels and sdLDL-C/LDL-C ratio may be used as diagnostic factors for coronary arteriostenosis in TA patients. K E Y W O R D S coronary arteriostenosis, lipoprotein(a), small dense low-density lipoprotein cholesterol, Takayasu arteritis How to cite this article: Chen S, Luan H, He J, et al. Serum concentrations of small dense low-density lipoprotein cholesterol and lipoprotein(a) are related to coronary arteriostenosis in Takayasu arteritis.

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Section: Discussionmentioning

confidence: 99%

Serum concentrations of small dense low‐density lipoprotein cholesterol and lipoprotein(a) are related to coronary arteriostenosis in Takayasu arteritis

Chen

Luan

et al. 2021

Clinical Laboratory Analysis

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“…Overproduction of Apo B-containing particles by the liver leads to the excessive biosynthesis of the heavier subfraction of LDL. ApoB reflects LDL particle number because all lipoprotein particles contain one molecule of ApoB 18) , and sdLDL is the most numerous particle among LDL particles 20) . Accordingly, there should be the close correlation between sdLDL-C and ApoB levels.…”

Section: Discussionmentioning

confidence: 99%

Small Dense Low-Density Lipoprotein Cholesterol is a Potential Marker for Predicting Laser Treatment for Retinopathy in Diabetic Patients

Nakayama

Morita

Sato

et al. 2022

JAT

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We explored the superiority of small dense low-density lipoprotein cholesterol (sdLDL-C) as a marker for predicting not only the occurrence of cardiovascular (CV) events but also the need for laser treatment in patients with hypercholesterolemia and diabetic retinopathy. Methods:We performed a sub-analysis of the intEnsive statin therapy for hyper-cholesteroleMic Patients with diAbetic retinopaTHY (EMPATHY) study (n 5042), in which patients were assigned randomly to intensive or standard statin therapy targeting low-density lipoprotein cholesterol 70 mg/dl or 100-120 mg/dl. Using the survival analysis, the risks for CV events and the need for laser treatment were evaluated according to the lipids one year after registration. Results:The patients were 63 11 years old. LDL-C and sdLDL-C levels were 98 25 and 32 14 mg/dl, respectively, one year after registration. The sdLDL-C level had a strong positive correlation with apolipoprotein B level (r 0.83 at registration). SdLDL-C was a sensitive marker for predicting CV events when comparing among the quartiles according to sdLDL-C levels (hazard ratios: HR for quartiles 1-4 were 1.0, 1.4, 1.6, and 2.5, respectively; p for trend 0.01). Also, sdLDL-C was a sensitive marker for predicting the need for laser treatment among lipids (log rank, p 0.009), especially in patients with elderly ( 65 yrs) and obesity (BMI 25 kg/m 2 ). Conclusions: SdLDL-C is a sensitive target marker to predict cardiovascular events as well as the need for laser treatment in patients with hypercholesterolemia and diabetic retinopathy.diseases 3,4) . Lipid markers other than LDL-C, such as total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), triglyceriderich lipoprotein cholesterol (TRL-C), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB), are also potential markers for predicting CV events 1,2,5,6,7) .

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“…Moreover, the present study used indistinctly NMR and standard biochemistry derived cut points assuming a high degree of concordance between techniques -in agreement with previous studies using both techniques. 24,39 However, it should be further demonstrated using specific calibration material in accordance with good clinical laboratory practices.…”

Section: Discussionmentioning

confidence: 99%

Analysis of LDL and HDL size and number by nuclear magnetic resonance in a healthy working population: The LipoLab Study

et al. 2020

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Background and aim Atherosclerosis is the underlying process in cardiovascular disease (CVD), the first cause of death in developed countries. We aimed to identify people with no known CVD and normal values of LDL‐C and HDL‐C, but with alterations in the number and size of lipoprotein particles (as measured by nuclear magnetic resonance [NMR]) and to analyse their sociodemographic, clinical and biochemical characteristics. Methods Cross‐sectional study in occupational risks prevention centre in Castellón (Spain) in 2017 and 2018, in consecutively recruited adults (18‐65 years) with no known CVD. Sociodemographic, clinical and biochemical variables were collected. Lipid profiles were analysed (Liposcale test), along with the concentration, size and number of the main types of lipoprotein particles, determined by 2D diffusion‐ordered NMR spectroscopy. Using contingency tables, we analysed the characteristics of people with normal LDL and HDL cholesterol but abnormal levels of LDL and HDL particles. The magnitude of association between explanatory variables and abnormal levels of each kind of lipoprotein was assessed with multivariable logistic regression models. Results Of the 400 total participants (31.3% women; age 46.4 ± 4.3 years), 169 had normal LDL and HDL cholesterol. Abnormal lipoprotein particle values depended on the subtype: prevalence of abnormal LDL levels ranged from 8.3% to 36.7%; and of HDL, from 28.4% to 42.6%. High systolic blood pressure and total cholesterol were significantly associated with abnormal LDL levels. Male sex and high systolic blood pressure were associated with abnormalities in HDL. Conclusions An extended lipids profile, obtained by NMR, enables the identification of people with normal HDL‐C and LDL‐C levels who present abnormal levels of LDL‐P and/or HDL‐P. Higher total cholesterol, systolic blood pressure, BMI and male sex were significantly associated with these abnormal values.

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Precipitated sdLDL: An easy method to estimate LDL particle size

Cited by 10 publications

References 30 publications

Serum concentrations of small dense low‐density lipoprotein cholesterol and lipoprotein(a) are related to coronary arteriostenosis in Takayasu arteritis

Serum concentrations of small dense low‐density lipoprotein cholesterol and lipoprotein(a) are related to coronary arteriostenosis in Takayasu arteritis

Small Dense Low-Density Lipoprotein Cholesterol is a Potential Marker for Predicting Laser Treatment for Retinopathy in Diabetic Patients

Analysis of LDL and HDL size and number by nuclear magnetic resonance in a healthy working population: The LipoLab Study

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