Precipitation Complexation Method Produces Cannabidiol/β-Cyclodextrin Inclusion Complex Suitable for Sublingual Administration of Cannabidiol

Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders

“…Other routes, including rectal, transdermic, eye drops, aerosols and intravenous have been used in a small number of studies so that the relevance of findings is limited. Recently, it was demonstrated in rabbits that sublingual administration of a solid CBD/beta-cyclodextrin complex may provide an alternative formulation for sublingual administration (Mannila et al, 2007). The pharmacokinetics of CBD is quite complicated and in many aspects resembles that of Δ9-THC.…”

Formulation of cyclodextrin inclusion complex-based orally disintegrating tablet of eslicarbazepine acetate for improved oral bioavailability

“…There are a number of US FDA (U.S. Food and Drug Administration) approved products of water insoluble drugs which utilize cyclodextrin inclusion technology. In addition to improving the solubility and taste masking of drugs [11], CD also improve their physical and chemical stability [12], absorption [13] and bioavailability [10].…”

“…Cyclodextrins can form host guest inclusion complexes by weak intermolecular interactions with a wide variety of guests including organic molecules, inorganic ions, and coordination compounds. This phenomenon was shown by researchers as one of the techniques of alleviating the issue of solubility of water insoluble drugs [8][9][10]. There are a number of US FDA (U.S. Food and Drug Administration) approved products of water insoluble drugs which utilize cyclodextrin inclusion technology.…”

Cannabidiol – Recent Advances

“…Mannila et al [27] have used a precipitation/complexation method to prepare a complex of CBD (2) with b-cyclodextrin (b-CD). The effect of b-CD complexation on the sublingual absorption of CBD was studied in rabbits.…”