Precise and fast control of the dissolved oxygen level for tumor-on-chip

Abstract

Oxalis features: independent control of pO2, pH and the liquid flowrate. pO2 equilibration time in the medium: 3 minutes. pO2 accuracy: 3 mmHg. Flowrate as low as 1 μL min−1 to avoid shear stress.

Shaping, Degradation And Drug Release Of Biosourced Particles Made From Acrylated Vegetable Oils

“…Concurrently, dissolved oxygen in the reactants may capture and consume free radicals, forming inactive peroxy radicals that inhibit monomer polymerization [33] . The high oxygen permeability of the PDMS channel further supplements oxygen from the surroundings [34] . The combination of these factors severely impedes the curing of AESO particles at the oil-water interface, leading to the aggregation of particles with a sticky hydrophobic surface.…”

Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies

“…We recently proposed an innovative method for on-chip oxygen control (Fig. 2 top panel) 62 called Oxalis (OXygen ALImentation System) that overcomes most of the cited limitations of current methods. Oxalis regulates simultaneously the gas composition and inlet reservoir pressure by modulating a pneumatic valve opening.…”

“…This method simultaneously changes the gas composition and the pressure-driven flow. 62 (Bottom panel) Gas channel: to control dissolved oxygen levels in the media and gel channels, gas mixtures can be supplied to the two separated gas channels. To prevent from atmospheric oxygen diffusion, a polycarbonate film is embedded on top of the gas channels.…”

Vascularized human brain organoid on-chip

“…For example, a recent study developed an open-top microfluidic chip with an integrated oxygen sensor to analyse the changes of oxygen metabolism in vascularized cancer organoids. 220,221…”