Precise, direct, and rapid detection of Shigella Spa gene by a novel unmodified AuNPs-based optical genosensing system

Enhanced antimicrobial treatment by a clay-based drug nanocarrier conjugated to a guanidine-rich cell penetrating peptide

“…As another useful species of the nanomaterials, iron oxide nanoparticles (Fe 3 O 4 NPs) has been widely used in different scopes such as drug delivery, 21,22 catalysis, 23,24 diagnosis, 25 medical imaging, 26 sensing, 27 removal of the pollutants, 28 and etc. 29,30 The first and foremost excellence of the Fe 3 O 4 NPs is its impressive magnetic property which leads to extensive use in different applications.…”

Progress and prospects of magnetic iron oxide nanoparticles in biomedical applications: A review

“…These features make them useful for applications in imaging, targeted drug delivery, photodynamic therapy (PDT), photothermal therapy (PTT), and nano biosensing. 107,120,121 Furthermore, goldcoated-SPIONs have been studied as a potential non-toxic carrier for magnetic fluid hyperthermia 118,122,123 as contrast agents for computed tomography (CT), and as optical sensors with significant therapeutic activity against liver tumor. 122 The anionic biocompatible nanoheterodimers of Au-Fe 3 O 4 were shown as an ideal high-capacity X-ray dosage enhancer in tumor cells.…”

“…Recent progress in the production of high-quality nanomaterials in different shapes, sizes, and surface modifications opens novel avenues to develop new biosensors. 148 Metal NPs 214 such as gold NPs, 107,120,121,215 silver NPs, 216,217 , and IONPs 107,218,219 have been applied for biomedical detection based on their intrinsic optical, magnetic, and electrical properties. The MNPs based biosensors provide superior detection compared to traditional detection techniques, which enables rapid, more sensitive, and selective sensing.…”

“…Among noble metal NPs, gold nanoparticles (AuNPs), have received significant attention due to their unique features such as high X‐ray absorption coefficient, the facile process of synthesis and manipulation, potent binding affinity to biomolecules and ligands, and tunable properties. These features make them useful for applications in imaging, targeted drug delivery, photodynamic therapy (PDT), photothermal therapy (PTT), and nano biosensing 107,120,121 . Furthermore, gold‐coated‐SPIONs have been studied as a potential non‐toxic carrier for magnetic fluid hyperthermia 118,122,123 as contrast agents for computed tomography (CT), and as optical sensors with significant therapeutic activity against liver tumor 122 .…”

Biosensors for the Detection of Bacterial and Viral Clinical Pathogens

“…In this study, AuNPs-DNA probes were hybridized with Spa gene sequence in order to create an optical genosensing system. This biosensor makes the sample solution turns to purple in the absence of the complementary target, whereas the solution remains red in the presence of the specific gene sequence [171]. On the other hand, Xiao et al covalently immobilized a DNA probe onto fiber-optic biosensors able to hybridize with a fluorescently labeled complementary DNA.…”