Precise Temperature Control of Donor Cornea Tissue With Reusable Passive Thermal Container

Tauber, Shachar; Bowman, John R.; Bango, J. J.; Fuerst, Randall

doi:10.1097/ico.0b013e318206862a

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…Australian eye banks have undertaken validation of temperature control in shipping containers under various simulated and actual conditions, and report that temperature fluctuations are small. Shaking, pressure changes, and rapid acceleration and deceleration may play a role 4 , 5 , 21 , 22 . Although our study has identified an association between air freight of donor corneas and subsequent poor outcomes after transplantation, we cannot identify the cause.…”

Section: Discussionmentioning

confidence: 65%

“…Shaking, pressure changes, and rapid acceleration and deceleration may play a role. 4,5,21,22 Although our study has identified an association between air freight of donor corneas and subsequent poor outcomes after transplantation, we cannot identify the cause. Further modification of corneal transport containers is difficult without a clearer understanding of the underlying cause of the problem.…”

Section: Discussionmentioning

confidence: 82%

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The influence of Australian eye banking practices on corneal graft survival

Keane

Lowe

Coster

et al. 2013

Medical Journal of Australia

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Objective: To identify eye banking practices that influence corneal graft survival. Design, setting and participants: Prospective cohort study of records of 19 254 followed corneal grafts in 15 160 patients, submitted to the Australian Corneal Graft Registry between May 1985 and July 2012. Main outcome measures: Influence of corneal preservation method (organ culture, moist pot, Optisol, other); death‐to‐enucleation, death‐to‐preservation and enucleation‐to‐graft times; transportation by air; graft era; and indication for graft on probability of graft survival at most recent follow‐up. Results: In multivariate analysis, 919 penetrating grafts performed using corneas transported interstate by air exhibited worse survival than 14 684 grafts performed using corneas retrieved and used locally (hazard ratio [HR], 1.44; 95% CI, 1.21–1.73; P = 0.001). This was also the case for traditional lamellar grafts (64 corneas transported by air and 813 used locally; HR, 1.69; 95% CI, 1.03–2.78; P = 0.038). Indication for graft influenced survival of penetrating grafts (4611 keratoconus, 727 emergency or high‐risk, 10 265 other indication; global P < 0.001) and traditional lamellar grafts (65 keratoconus, 212 emergency or high‐risk, 600 other indication; global P < 0.001). The preservation medium in which corneas used for traditional lamellar grafts were stored exerted a marginal influence on graft survival (global P = 0.047). Conclusions: Donor corneas transported interstate exhibited poorer survival after transplantation than those retrieved and grafted locally. Higher proportions of emergency procedures involving transported corneas did not account for this difference. Where possible, efforts to avoid transportation of corneal tissue by air freight within Australia may be warranted.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 82%

The influence of Australian eye banking practices on corneal graft survival

Keane

Lowe

Coster

et al. 2013

Medical Journal of Australia

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“…Tauber et al reported precise temperature control of donor cornea tissue with a reusable thermal container. 21 This newly developed device maintained steady acceptable air temperatures compared to conventional polystyrene containers with wet ice. Although this is a move forward in transportation methods for the donor cornea, only temperature stability was evaluated in the article.…”

mentioning

confidence: 93%

Development of a Cell Sheet Transportation Technique for Regenerative Medicine

Oie

Nozaki

Takayanagi

et al. 2014

Tissue Engineering Part C: Methods

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“…In contrast, the use of passive thermal container (Temp Shells, delta T GmbH, Fernwald, Germany) for transportation assured a safe temperature range for low ambient temperatures (−10 to +10°C) for at least 24 h and for an ambient temperature of +50°C for at least 10 h [9]. Tauber et al confirmed the usefulness of passive thermal container for corneal transportation between 2 and 8°C [15]. The containers and ways of transport should be validated by the cornea bank to ensure a safe range of temperature [7].…”

Section: Discussionmentioning

confidence: 96%

“…Despite years of advancements in corneal transplantation, an ongoing concern of surgeons is the temperature stability of donor tissue during transport [15].…”

Section: Discussionmentioning

confidence: 99%

Impact of temporary hyperthermia on corneal endothelial cell survival during organ culture preservation

Schroeter¹,

Ruggeri

Thieme

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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To evaluate temporary exposure to hyperthermia for its impact on endothelial cell density of porcine corneas in organ culture medium containing dextran with regards to possible negative influences of high temperatures during the storage and transport of corneal grafts. Four groups of central discs (diameter 8 mm) from the corneas of both eyes in 40 pigs were first organ-cultured (MEM with 6% dextran 500) for 24 h at 32°C. Ten corneas were then exposed to 40°C in group 1, to 42°C in group 2, to 44°C in group 3, and to 50°C in group 4 for 12 h each. The paired corneal discs for all groups were not treated, stored at 32°C and served as controls. After further organ culture of all corneas for 48 h at 32°C to allow regenerative processes, corneal endothelium was stained with Alizarin Red S and examined by light microscopy. The endothelial cell densities were determined on three central images using a system for the automatic estimation of morphometric parameters of corneal endothelium. Exposure for 12 h to 40°C as well as to 42°C induced no endothelial cell loss. Statistical analysis showed no significant difference of the endothelial cell density between corneas exposed to 40°C and 42°C and the control corneas (40°C treatment: 4736 ± 426 cells/mm(2) and control: 4762 ± 344 cells/mm(2), p = 0.74; 42°C treatment: 4240 ± 363 cells/mm(2) and control: 4176 ± 448 cells/mm(2), p = 0.40). Exposure to 44°C and 50°C lead to total necrosis of the endothelial cell layer. Exposure of organ cultured porcine corneas in dextran containing medium up to 42°C for 12 h does not compromise the endothelial cell density in a clinically relevant manner. Temperatures above 42°C, as it might be the case during transports from the cornea bank to the ophthalmic surgeon, must be strictly avoided as they damage the endothelial cell layer.

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Precise Temperature Control of Donor Cornea Tissue With Reusable Passive Thermal Container

Cited by 5 publications

References 11 publications

The influence of Australian eye banking practices on corneal graft survival

The influence of Australian eye banking practices on corneal graft survival

Development of a Cell Sheet Transportation Technique for Regenerative Medicine

Impact of temporary hyperthermia on corneal endothelial cell survival during organ culture preservation

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