Precision, accuracy, and reliability of hemoglobin assessment with use of capillary blood

Morris, Saul S.; Ruel, Marie T.; Cohen, Roberta J.; Dewey, Kathryn G.; Brière, Bénédicte de la; Hassan, Mohammed N

doi:10.1093/ajcn/69.6.1243

Cited by 112 publications

(122 citation statements)

References 11 publications

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“…When used by trained laboratory personnel, the precision of the HemoCue is very good. 49 The mean difference between our study HemoCue measurements and Sysmex analyzer readings was -0.29 g/dl (SD 0.03 g/dl). Thus, 95% of misclassification of Hb changes from enrollment to second measurement should lie in the range of 1.0 -0.12 g/dl.…”

Section: Discussionmentioning

confidence: 50%

Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline

Brentlinger¹,

Silva

Vermund

et al. 2016

AIDS Research and Human Retroviruses

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Mozambique's updated guideline for management of HIV-associated anemia prompts clinicians to consider opportunistic conditions, adverse drug reactions, and untreated immunosuppression in addition to iron deficiency, intestinal helminthes, and malaria. We prospectively evaluated this guideline in rural Zambézia Province. Likely cause(s) of anemia were determined through prespecified history, physical examination, and laboratory testing. Diagnoses were ''etiologic'' if laboratory confirmed (sputum microscopy, blood culture, Plasmodium falciparum malaria rapid test) or ''syndromic'' if not. To assess hemoglobin response, we used serial point-of-care measurements. We studied 324 ambulatory, anemic (hemoglobin <10 g/dl) HIV-infected adults. Study clinicians treated nearly all [315 (97.2%)] for suspected iron deficiency and/or helminthes; 56 (17.3%) had laboratory-confirmed malaria. Other assigned diagnoses included tuberculosis [30 (9.3%)], adverse drug reactions [26 (8.0%)], and bacteremia [13 (4.1%)]. Etiologic diagnosis was achieved in 79 (24.4%). Of 169 (52.2%) subjects who improved (hemoglobin increase of ‡1 g/dl without indications for hospitalization), only 65 (38.5%) received conventional management (iron supplementation, deworming, and/or antimalarials) alone. Thirty (9.3%) died and/or were hospitalized, and 125 (38.6%) were lost to follow-up. Multivariable linear and logistic regression models described better hemoglobin responses and/or outcomes in subjects with higher CD4 + T-lymphocyte counts, pre-enrollment antiretroviral therapy and/or co-trimoxazole prophylaxis, discontinuation of zidovudine for suspected adverse reaction, and smear-positive tuberculosis. Adverse outcomes were associated with fever, low body mass index, bacteremia, esophageal candidiasis, and low or missing CD4 + T cell counts. In this severely resource-limited setting, successful anemia management often required interventions other than conventional presumptive treatment, thus supporting Mozambique's guideline revision.

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Section: Discussionmentioning

confidence: 50%

Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline

Brentlinger¹,

Silva

Vermund

et al. 2016

AIDS Research and Human Retroviruses

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“…The serious functional consequences of this deficiency demand the design and implementation of public iron supplementation and food fortification programs as the most effective strategies to reduce iron-deficiency anemia. Data presented here show a persistently high prevalence of anemia in Mexico among pregnant and non- 27 , and the amount of extracellular fluid present in finger-prick samples is likely to be very sensitive to the technician's handling of the patient's finger.…”

Section: Discussionmentioning

confidence: 88%

Anemia in Mexican women: a public health problem

Shamah‐Levy¹,

Villalpando²,

Rivera³

et al. 2003

Salud pública Méx

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Objective. The purpose of this study is to quantify the prevalence and distribution of anemia among women of childbearing age (12 to 49 years) participating in the 1999 National Nutrition Survey (NNS-1999). Material and Methods. The survey had a probabilistic design and was representative at the national level, of urban and rural areas and four regions: North, South, Center, and Mexico City. Hemoglobin concentration was determined in capillary blood samples using a portable photometer (HemoCue), in 17 194 women, 697 of whom were pregnant. Results. The overall prevalence of anemia was 27.8% in pregnant women and 20.8% in non-pregnant women. Higher prevalences were observed in rural as compared to urban areas, both in pregnant (28.0% vs 27.7%) and non-pregnant (22.6% vs 20.0%) women, but the differences were not statistically significant (p >0.05). Women in the South had the greatest prevalence (23.2%), followed by those in the North (20.9%), Center (20.6%), and Mexico City (16.4%). Non-pregnant indigenous women had a prevalence of 24.8%, while in non-indigenous women the prevalence was 20.4%. Conclusions. Anemia in women of childbearing age is a growing public health problem that justifies the implementation of interventions for its prevention and control. The English version of this paper is available too at: http://www.insp.mx/salud/index.html Shamah-Levy T et alA nemia is the most frequent nutritiona-related disease worldwide, affecting half of children and pregnant women and between 20 and 25% of non-pregnant women in developing countries. 1 Both nutritional and non-nutritional factors may cause anemia. The most common nutritional cause is iron deficiency. Other nutritional causes are deficiencies of vitamin B 12 , folic acid, and vitamin A. [2][3][4] Among the non-nutritional causes of anemia are intestinal parasitic infections such as uncinariasis and trichinosis. [5][6][7][8] Other causes include hemodilution during pregnancy, concurrent acute and chronic infections, and menstrual bleeding. 9,10 Iron deficiency also has deleterious effects on the immune response, exercise endurance, cognitive ability, and psychosocial development. 11,12 The extent to which anemia affects the health of mothers and of their newborns is not completely established, but some studies suggest that anemia during pregnancy has adverse effects on both the mother and the fetus. 13,14 Moreover, severe anemia greatly increases the risk of maternal death. 10,14 Insufficient maternal iron stores are reflected in low iron stores in the newborn, leading to increased risk of iron deficiency in the first months of life. Iron deficiency may also have long-term consequences on the health of both mother and child. For example, iron deficiency anemia is associated with birth weight and pre-term birth.The most recent information on the extent and distribution of anemia in Mexico was reported in the 1988 National Nutrition Survey. 15 The present study was designed to quantify the prevalence and describe the distribution of anemia in women...

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“…Each site was cleansed with an alcohol wipe, dried and a sterile lancet applied. The first drop of blood was discarded with blood collected into duplicate 100 µL heparinised capillary tubes for haematocrit (Hct) determination and microcuvettes for haemoglobin ( Hct by 2 independent reviewers (Morris et al 1999). Changes in PV (%) were calculated from the following equation (Strauss et al 1951):…”

Section: Hydration Status and Plasma Volume Assessmentmentioning

confidence: 99%

Effect of sauna-based heat acclimation on plasma volume and heart rate variability

et al. 2014

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Anthony S. (2015) Effect of sauna-based heat acclimation on plasma volumeand heart rate variability. European Journal of Applied Physiology, 115 (4). pp. immediately following normal training. Capillary blood samples were collected to assess PV changes while resting seated. HR (HR wake ) and vagal-related HR variability (natural logarithm of square-root mean squared differences of successive R−R intervals, ln rMSSD wake ) were assessed daily upon waking. A sub-maximal cycle test (5 min at 125 W) was performed on days 1, 8, 15, 22, 25, 29, and 35 and HR recovery (HRR 60s ) and ln rMSSD postex were assessed post-exercise. Effects were examined using magnitude-based inferences. Conclusions: Sauna-bathing following normal training largely expanded PV in well-trained cyclists after just 4 Resultsexposures. The utility of HR and HRV indices for tracking changes in PV was however uncertain. Future studies will clarify mechanisms and performance benefits of post-training sauna bathing.

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Precision, accuracy, and reliability of hemoglobin assessment with use of capillary blood

Cited by 112 publications

References 11 publications

Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline

Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline

Anemia in Mexican women: a public health problem

Effect of sauna-based heat acclimation on plasma volume and heart rate variability

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