Precision control of the large-scale green synthesis of biodegradable gold nanodandelions as potential radiotheranostics

Chuang, Yao-Chen; Hsia, Yu; Chu, Chia-Hui; Lin, Li-Jie; Sivasubramanian, Maharajan; Lo, Leu‐Wei

doi:10.1039/c9bm00897g

Cited by 10 publications

(6 citation statements)

References 38 publications

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“…Our previous studies proposed that gold nanodandelions (GNDs) with a high surface area significantly enhanced radiosensitization-induced ROS generation and anticancer drug loading and inhibited tumor growth in vivo . , In addition, the biodegradation of GNDs was also observed in in vitro and in vivo studies. However, the mechanism of biodegraded GNDs remains to be clarified.…”

Section: Introductionmentioning

confidence: 91%

“…20 On the other hand, 13 nm AuNPs were used in Cao's study as peroxidase-mimicking nanozyme to develop a simple, low-cost, and easy-to-use nanosensor for the detection of proteolytic enzyme. 21 Our previous studies proposed that gold nanodandelions (GNDs) with a high surface area significantly enhanced radiosensitization-induced ROS generation and anticancer drug loading and inhibited tumor growth in vivo. 22,23 In addition, the biodegradation of GNDs was also observed in in vitro and in vivo studies.…”

Section: ■ Introductionmentioning

confidence: 99%

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Gold Nanodandelions as Nanozymes and Reactive Oxygen Species Scavengers in Tumor Microenvironment Components

Lee,

Chuang,

Tsai

et al. 2023

ACS Appl. Nano Mater.

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Gold nanomaterials have attracted increasing attention in biomedical applications due to their biocompatibility and intrinsic optical and physicochemical properties. Oxidative stress, which is mainly contributed by reactive oxygen species (ROS), has been crucial in various cancers and diseases. Here, we report a gold nanodandelion (GND)-based ROS-scavenging system using the antioxidant properties of GNDs. GNDs scavenge superoxide anions and hydroxyl radicals in situ and induce oxidative etching with hydrogen peroxide (H 2 O 2 ). The size and surface passivation of gold nanomaterials regulated the efficiency of ROS scavenging. The differential effect of GNDs to scavenge intracellular ROS was studied through cell viability, nanoparticle uptake, ROS production, and antioxidant enzymes. Results indicated that GNDs in normal fibroblasts and macrophages display minimal toxicity and provide protection from H 2 O 2 -induced oxidative stress. For the first time, GNDs exhibit outstanding nitric oxide (NO • ) generation performance in M1 macrophage. Interestingly, the presence of GNDs in glioma cells attenuated cell proliferation, migration, and invasion behaviors. GNDs are expected to be a promising antioxidant in cancer treatment and tumor microenvironment modulation.

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Section: Introductionmentioning

confidence: 91%

Section: ■ Introductionmentioning

confidence: 99%

Gold Nanodandelions as Nanozymes and Reactive Oxygen Species Scavengers in Tumor Microenvironment Components

Lee,

Chuang,

Tsai

et al. 2023

ACS Appl. Nano Mater.

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“…From the clinical perspective, tumor microenvironment (TME)-responsive PTT-agents may be a promising strategy for the treatment of glioma, which is one of the most aggressive and common intracranial tumors. Accumulated evidence indicates that the amounts of matrix metalloproteinases (MMPs) protein, especially MMP-2 and MMP-9, are significantly increased in patients with malignant glioma, particularly in glioblastoma multiforme. , Previously, we have developed a facile, large-scale synthesis of multibranched, flower-like AuNPs, i.e., gold nanodandelions (GNDs), using a novel gelatin-directed method and demonstrated significantly enhanced radiosensitization-induced ROS generation and anticancer drug loading . In this study, we further the equip GND nanoplatform with the theranostic applicability of PA-guided PTT and demonstrate its in vivo modulation of induced cancer metastasis.…”

Section: Introductionmentioning

confidence: 92%

Photothermal Temperature-Modulated Cancer Metastasis Harnessed Using Proteinase-Triggered Assembly of Near-Infrared II Photoacoustic/Photothermal Nanotheranostics

Chuang,

Hsia,

Chu

et al. 2024

ACS Appl. Mater. Interfaces

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Here we demonstrate that cancer metastasis could be modulated by the judicious tuning of physical parameters such as photothermal temperature in nanoparticle-mediated photothermal therapy (PTT). This is supported by theranostic nanosystem design and characterization, in vitro and in vivo analyses, and transcriptome-based gene profiling. In this work, the highly efficient nearinfrared II (NIR-II) photoacoustic image (PA)-guided PTT are selectively activated using our developed matrix metalloproteinase (MMP)-triggered in situ assembly of gold nanodandelions (GNDs@gelatin). Unlike other "always-on" NIR PTT agents lacking specific bioactivation and suffering from the intrinsic nonspecific pseudosignals and treatment-related side effects such as metastasis, our GNDs@gelatin possesses important advantages while deployed in cancer PTT that include the following: (1) The theranostic effects could be "turned on" only after specific MMP-2/-9 activity and with acidity in the tumor microenvironment.(2) The quantitative PA diagnosis allows for precise PTT planning for better cancer treatment. (3) GNDs@gelatin could noninvasively quantify MMP activity and efficiently harness NIR-I (808 nm) and NIR-II (1064 nm) energies for tumor ablation. (4) The multibranched nanostructures reabsorb scattered laser photons, thus enhancing the surface plasmons for the pronounced photothermal conversion of aggregated GNDs@gelatin in situ. (5) It is noteworthy that in situ tumor eradication at higher PTT temperature (>55 °C) mediated by GNDs@gelatin could induce subsequent metastasis, which could be otherwise abolished at lower PTT temperatures (50 °C > T > 43 °C). (6) Furthermore, the gene profiling using transcriptome-based microarray including GO and KEGG analyses revealed that 315 differentially expressed genes were identified in higher PTT temperature treated tumors compared with lower PTT temperature ones. These were enriched into some well-known cancer-related pathways, such as cell migration pathway, signal transductions, cell proliferation, wound healing, PPAR signaling, and metabolic pathways. These observations suggest a new perspective of "moderate-is-better" in nanoparticle-mediated PTT for maximizing its therapeutic/ prognosis benefits and translational potential with metastasis inhibition.

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“…In nanoparticle-mediated hyperthermia, GNPs can absorb strong NIR radiation and then produce the primary source of heat and reverse the direction of heat loss to stimulate thermal ablation on tumor cell [ 83 , 84 , 85 , 86 ]. Currently, various gold nanostructures have been translated for clinical trials ( Table 3 ), potential struggle has resulted in the reports of multiple research works on gold-based phototherapies in the recent literature such as gold nanocages, nanobipyramids, nanoflowers, nanoshell, nanorods, hollow nanospheres, nanostars, nanoechius and plasmonic blackbodies [ 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 ]. However, significant translations of these nanomaterials to pre-clinical trials have not yet been attained.…”

Section: Phototherapies-based Clinical Trials In Gold Nanostructurementioning

confidence: 99%

Recent Progress of Gold-Based Nanostructures towards Future Emblem of Photo-Triggered Cancer Theranostics: A Special Focus on Combinatorial Phototherapies

Sekar¹,

Basavegowda

Thathapudi

et al. 2023

Pharmaceutics

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Cancer is one of the most dangerous health problems in the millennium and it is the third foremost human cause of death in the universe. Traditional cancer treatments face several disadvantages and cannot often afford adequate outcomes. It has been exhibited that the outcome of several therapies can be improved when associated with nanostructures. In addition, a modern tendency is being developed in cancer therapy to convert single-modal into multi-modal therapies with the help of existing various nanostructures. Among them, gold is the most successful nanostructure for biomedical applications due to its flexibility in preparation, stabilization, surface modifications, less cytotoxicity, and ease of bio-detection. In the past few decades, gold-based nanomaterials rule cancer treatment applications, currently, gold nanostructures were the leading nanomaterials for synergetic cancer therapies. In this review article, the synthesis, stabilization, and optical properties of gold nanostructures have been discussed. Then, the surface modifications and targeting mechanisms of gold nanomaterials will be described. Recent signs of progress in the application of gold nanomaterials for synergetic cancer therapies such as photodynamic and photo-thermal therapies in combination with other common interventions such as radiotherapy, chemotherapy, and will be reviewed. Also, a summary of the pharmacokinetics of gold nanostructures will be delivered. Finally, the challenges and outlooks of the gold nanostructures in the clinics for applications in cancer treatments are debated.

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Precision control of the large-scale green synthesis of biodegradable gold nanodandelions as potential radiotheranostics

Abstract: Herein, we report a new type of biodegradable, high surface-area gold nanodandelions (GNDs) as potential radiotheranostics.

Cited by 10 publications

References 38 publications

Gold Nanodandelions as Nanozymes and Reactive Oxygen Species Scavengers in Tumor Microenvironment Components

Gold Nanodandelions as Nanozymes and Reactive Oxygen Species Scavengers in Tumor Microenvironment Components

Photothermal Temperature-Modulated Cancer Metastasis Harnessed Using Proteinase-Triggered Assembly of Near-Infrared II Photoacoustic/Photothermal Nanotheranostics

Recent Progress of Gold-Based Nanostructures towards Future Emblem of Photo-Triggered Cancer Theranostics: A Special Focus on Combinatorial Phototherapies

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