Preclinical Evidence for the Pharmacological Actions of Naringin: A Review

Bharti, Sudhakar; Rani, Neha; Krishnamurthy, Bhaskar; Arya, Dharamvir Singh

doi:10.1055/s-0034-1368351

Cited by 210 publications

(134 citation statements)

References 202 publications

(207 reference statements)

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“…The effect of naringin on UMR-106 and MG-63 osteosarcoma cells is dosedependent over the concentration range of 1-100 lg/mL (Chen et al 2013;Bharti et al 2014).…”

Section: In Vitromentioning

confidence: 99%

“…In UMR-106 cells, naringin has been demonstrated to augment osteoblastic activity via inhibition of hepatic 3-hydroxy-3-methyl CoA (HMG-CoA) reductase (Bharti et al 2014). Naringin mimicked the effects of oestrogen by stimulating cell proliferation as well as modulating alkaline phosphatase (ALP) activity and OPG/RANKL mRNA expression (Wong et al 2013).…”

Section: In Vitromentioning

confidence: 99%

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Therapeutic potential of naringin: an overview

Chen

Wang

et al. 2016

Pharmaceutical Biology

313

166

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Context: Naringin is a natural flavanone glycoside that is found in the Chinese herbal medicines and citrus fruits. Studies have demonstrated that naringin possesses numerous biological and pharmacological properties, but few reviews of these studies have been performed. Objective: The present review gathers the fragmented information available in the literature describing the extraction of naringin, its pharmacology and its controlled release formulations. Current research progress and the therapeutic potential of naringin are also discussed. Methods: A literature survey for relevant information regarding the biological and pharmacological properties of naringin was conducted using Pubmed, Sciencedirect, MEDLINE, Springerlink and Google Scholar electronic databases from the year 2007-2015. Results: Naringin modulates signalling pathways and interacts with signalling molecules and thus has a wide range of pharmacological activities, including anti-inflammatory, anti-cancer activities, as well as effects on bone regeneration, metabolic syndrome, oxidative stress, genetic damage and central nervous system (CNS) diseases. Information was gathered that showed the extraction of naringin can be improved using several modifications. There has been some progress in the development of controlled release formulations of naringin. Conclusion: Naringin is a promising candidate for further in vivo studies and clinical use. More detailed studies regarding its mechanism of action are required. ARTICLE HISTORY

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“…The effect of naringin on UMR-106 and MG-63 osteosarcoma cells is dosedependent over the concentration range of 1-100 lg/mL (Chen et al 2013;Bharti et al 2014).…”

Section: In Vitromentioning

confidence: 99%

Section: In Vitromentioning

confidence: 99%

Therapeutic potential of naringin: an overview

Chen

Wang

et al. 2016

Pharmaceutical Biology

313

166

View full text Add to dashboard Cite

show abstract

“…1) is markedly increased compared with that of compounds from Pomelo (11). A further study suggested that naringin exhibits anti-atherosclerosis and anticancer effects, and also improves myocardial ischemia and immune regulation (12).…”

Section: Mir-126/vcam-1 Regulation By Naringin Suppresses Cell Growthmentioning

confidence: 96%

miR‑126/VCAM‑1 regulation by naringin suppresses cell growth of human non‑small cell lung cancer

Chen

Peng

et al. 2018

Oncol Lett

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Abstract. Certain studies have indicated that naringin possesses various pharmacological activities including anti-aging, anti-oxidation, anticancer, cardiovascular and cerebrovascular disease prevention, in addition to anti-hepatic effects. The present study explores the anticancer effect of naringin on human small cell lung cancer H69AR cells. Cell growth and apoptosis rates of H69AR cells were measured by MTT or flow cytometry, which demonstrated naringin suppressed cell growth and induced apoptosis of H69AR cells. MicroRNA (miR)-126 expression and levels of phosphorylated protein kinase B (AKT), mechanistic target of rapamycin (mTOR), nuclear factor (NF)-κB and vascular cell adhesion molecule 1 (VCAM-1) proteins were detected by quantitative polymerase chain reaction and western blotting. It was identified that naringin increased miR-126 expression and suppressed the phosphorylation of AKT, mTOR, NF-κB and VCAM-1 proteins in H69AR cells. Suppression of miR-126 expression reduced the anticancer effects of naringin on H69AR cells, reversed the naringin-induced reduction of phosphoinositide 3-kinase/AKT/mTOR, and suppressed VCAM-1 protein levels. However, close of miR-126 expression did not affect the levels of NF-κB protein in H69AR cells. In summary, naringin exhibits its anti-cancer effect by suppressing cell growth of small cell lung cancer cells through miR-126/VCAM-1 signaling pathway.

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“…1), obtained from various species of citrus, was reported to be effective in inflammation, atherosclerosis, diabetes and neurogenrative disorders [7] . Naringin and other flavonoids scavenged free radicals due to the presence of phenolic hydroxyl groups [8][9][10][11] .…”

Section: Research Papermentioning

confidence: 99%

Protective Effect of Naringin against Pylorus Ligation-induced Esophagitis in Male Wistar Rats

Shalini¹,

Kumar²,

Singh³

et al. 2017

Journal of Pharmaceutical Sciences

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Shalini, et al.: Naringin and Pylorus Ligation-induced Esophagitis in RatsThe present study was undertaken to evaluate the effect of naringin, a naturally occurring flavonoid, on experimental esophagitis in Wistar rats. Animals divided into six groups and received carboxymethyl cellulose (0.25%, 3 ml/kg, sham control), standard pantoprazole (30 mg/kg) and naringin (100, 200 and 300 mg/kg) for 7 d orally and subjected to pylorus and forestomach ligation. All animals were sacrificed after 8 h and evaluated for various physiological parameters like total acidity, free acidity, gastric pH, volume of gastric juices and esophagitis index. Esophagitis regions were further subjected to estimation of various oxidative stress parameters including thiobarbituric acid reactive substances, glutathione, catalase and superoxide dismutase. Later, histopathology and scanning electron microscopy of esophagitis regions were also performed to evaluate protective action of naringin. Results revealed that treatment with pantoprazole and naringin significantly inhibited the gastric secretion, total acidity and esophagitis index. Various oxidative stress parameters were restored to normal level in the treatment groups. Histopathology and scanning electron microscopy analyses demonstrated the protective action of naringin as evidenced by normal tissue architecture of esophagitis regions. These findings indicate the potential of naringin against esophagitis.

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Preclinical Evidence for the Pharmacological Actions of Naringin: A Review

Cited by 210 publications

References 202 publications

Therapeutic potential of naringin: an overview

Therapeutic potential of naringin: an overview

miR‑126/VCAM‑1 regulation by naringin suppresses cell growth of human non‑small cell lung cancer

Protective Effect of Naringin against Pylorus Ligation-induced Esophagitis in Male Wistar Rats

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