Preclinical Evidence for the Role of Stem/Stromal Cells in COPD

Bölükbas, Deniz A.; Silva, Iran Augusto Neves Da; Rydell‐Törmänen, Kristina; Wagner, Darcy E.

doi:10.1007/978-3-030-29403-8_5

Cited by 1 publication

(1 citation statement)

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“…Cell therapy approaches seek either to replace damaged tissue through delivery and engraftment of administered cells or to stimulate endogenous repair and regeneration via immunomodulation. A variety of cell types and cell-derived products are currently being explored, with many showing a remarkable capacity to contribute to lung repair in pre-clinical small and large animal models [113][114][115][116][117]. Owing to their success in pre-clinical models, several different cell types have been explored in clinical trials for lung diseases.…”

Section: Cell Therapymentioning

confidence: 99%

Lung regeneration: implications of the diseased niche and ageing

et al. 2020

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Most chronic and acute lung diseases have no cure, leaving lung transplantation as the only option. Recent work has improved our understanding of the endogenous regenerative capacity of the lung and has helped identification of different progenitor cell populations, as well as exploration into inducing endogenous regeneration through pharmaceutical or biological therapies. Additionally, alternative approaches that aim at replacing lung progenitor cells and their progeny through cell therapy, or whole lung tissue through bioengineering approaches, have gained increasing attention. Although impressive progress has been made, efforts at regenerating functional lung tissue are still ineffective. Chronic and acute lung diseases are most prevalent in the elderly and alterations in progenitor cells with ageing, along with an increased inflammatory milieu, present major roadblocks for regeneration. Multiple cellular mechanisms, such as cellular senescence and mitochondrial dysfunction, are aberrantly regulated in the aged and diseased lung, which impairs regeneration. Existing as well as new human in vitro models are being developed, improved and adapted in order to study potential mechanisms of lung regeneration in different contexts. This review summarises recent advances in understanding endogenous as well as exogenous regeneration and the development of in vitro models for studying regenerative mechanisms.

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Section: Cell Therapymentioning

confidence: 99%