Preclinical Research into Basic Mechanisms of Radiation-Induced Heart Disease

Boerma, Marjan; Hauer‐Jensen, Martin

doi:10.4061/2011/858262

Cited by 73 publications

(70 citation statements)

References 123 publications

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“…In the Figure 2(a) we could observe that the LV tissue was intact, the cells were organized, and no fibrosis was identified. This is corroborated by other studies that compare the cardiac tissue of healthy animals with the same tissue of animals treated with cardiotoxic drugs by clinical exams [31].…”

Section: Discussionsupporting

confidence: 78%

“…The maps were obtained for different elements, but we chose three elements of great importance for the cardiac health: Na, Mg and Fe. By determining the elemental distribution in healthy tissue, we can evaluate the possible damages and relate them to structural changes [28] [29] [30] [31]. Elemental maps can be correlated to the absorption and phase contrast images that provide information on specimen morphology, in order to identify the elemental changes that cause any structural damage.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding radiotherapy treatment for BC using photons, it is known that the radiation-induced heart disease (RIHD) is a late effect caused by radiation in the thoracic region, when all or part of the heart is in the radiation field. Among the manifestations of RIHD are valvulopahy, pericarditis and myocardial fibrosis [20]. It is, therefore, important to understand the mechanisms involved in the cardio toxicity, in order to prevent women from this late effect, when they un-dergo BC treatments.…”

Section: Introductionmentioning

confidence: 99%

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Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

Mantuano¹,

Barroso²,

Nogueira³

et al. 2016

AJAC

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Data from Global Cancer Statistics show that breast cancer (BC) is the most common type of cancer among women, leading the number of deaths caused by cancer. The developments in diagnosis and treatment techniques for the BC, including chemotherapy and/or radiotherapy, increased the survival rates for this type of cancer. One late complication induced by BC treatment is the cardiotoxicity. This term comprises different cardiotoxic side effects, which include blood pressure alterations, myocardial ischemia, congestive heart failure and other damages. This study aimed to evaluate the cardiac alterations induced by radiotherapy and chemotherapy, simulating a treatment for BC in Wistar rats. It is, therefore, important to understand the mechanisms involved in the cardiotoxicity, in order to prevent women from this late effect, when they undergo BC treatments. The major interests in this work are in Low atomic weight elements as Sodium, because it is strongly related to cardiomyocyte contraction; Magnesium, because it is important in the cardiac metabolism; and Iron, because BC treatment induced cardiotoxicity can be associated to the oxidative stress. Changes that occur in unhealthy tissues in case to cardiovascular damages can be better understood when elemental compounds and structures of healthy tissues are known. Low Energy X-ray Fluorescence (LEXRF) technique was used to obtain elemental maps of low Z-elements providing a semi-quantitative analysis of the tissues evaluated under different conditions. Through the technique LEXRF we obtained elemental and absorption maps. The results showed more damages when associating chemotherapy and radiotherapy in comparison to myocardium healthy. Those images taken together with light microscopy, X-ray absorption and phase How to cite this paper: Mantuano, A., Barroso, R.C., Nogueira, L.P., Colaço, M.V., Mota, C.L., Pickler, A., Braz, D., Salata, C., Ferreira-Machado, S., de Almeida, C.E. and 755contrast images, satisfactorily characterize the cardiac tissue for the first time in the literature, from the structural and morphological points of view. LEXRF was carried out at TwinMic beamline in the ELETTRA Synchrotron Facility, at the beamline TwinMic, in Trieste, Italy.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

Mantuano¹,

Barroso²,

Nogueira³

et al. 2016

AJAC

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“…1 Ionizing radiations induce oxidative stress, mainly through the generation of reactive oxygen species(ROS) resulting in imbalance of the pro-oxidant and antioxidant in the cells and attack different cellular macromolecules leading to cell death. 2 Diabetes mellitus (DM) is a pathologic conditions resulting in severe metabolic imbalances in many tissues. It generates ROS through various pathways, such as damage of the redox equilibrium or overproduction of mitochondrial superox- ides, which leads to oxidative stress in variety of tissues.…”

Section: Introductionmentioning

confidence: 99%

Modulatory Role of Selenium Nanoparticles and Grape Seed Extract Mixture on Oxidative Stress Biomarkers in Diabetic Irradiated Rats.

Abdelaleem¹,

Hameed²,

Askar³

et al. 2016

IJPER

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Introduction: Diabetes is a metabolic disorder of several etiologies, many oral anti-hyperglycemic agents such as sulfonylurea, biguanides are obtainable, but these agents have side effects, thus there is need of a new natural anti-hyperglycemic agent. Methods: The present study was performed to evaluate the protective role of selenium nanoparticles-grape seed extract (SeNPs-GSE) mixture in ameliorating the changes in the oxidative stress biomarkers induced by gamma radiation in diabetic rats. Experimental model of diabetic irradiated rats was induced by single intrapertoneal injection of streptozotocin (STZ 45 mg/kg) followed by γ-radiation exposure (4 Gy). Forty eight rats were randomly classified into 6 experimental groups: normal, diabetic, irradiated, diabetic irradiated, diabetic treated with either SeNPs-GSE mixtureor glimepiride(1 mg) for (14) days followed by γ-radiation. Results: Results of the present study indicated that rats exposed to γ-radiation and, or STZ significantly increase serum glucose& liver MDA levels. This increase was accompanied by a decrease in the levels of serum insulin, total antioxidant (TAC), liver enzyme activities of catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), as well as liver tissue contents of vitamin C (Vit.C) and vitamin E (Vit.E). Diabetic rats treated with (SeNPs-GSE) mixture or glimepiride before γ-radiation exert a significant improvement in all tested biochemical parameters. Conclusion:The present study showed that a mixture of (SeNPs -GSE) possesses antioxidant and anti-diabetic activities by decreasing oxidative stress biomarkers as well as blood glucose level tested in this study. The tested combination (SeNPs-GSE) mixture is more or less equally active as that of the standard tested anti-diabetic drug glimepiride

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“…In this context, the endothelial dysfunction plays an important role in promoting fi brotic and infl ammatory processes after irradiation [5]. Radiation--induced endothelial injury has been described as a crucial event in initiation of normal tissue damage [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of circulating endothelial cells in the rat after acute and fractionated whole-body gamma irradiation

Al-Massarani

Almohamad

2014

Nukleonika

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Abstract.Purpose: Damage to vascular endothelial cells is a well recognised complication of the irradiation. Our objective was to determine the gamma-irradiation effect on the rat circulating endothelial cells (CEC). Material and methods: Eight-week old rats were divided into four groups: group 1 -rats were exposed to acute whole--body gamma irradiation with a wide range of single doses (0.5, 1, 2, 4 and 8 Gy), group 2 -rats were exposed to fractionated low doses of irradiation (0.1, 0.5 and 1 Gy) every three days for two months, group 3 as group 2, but followed by two months of rest, group 4 were control animals. CEC (CD146 positive cells) in group 1 were counted following CD146-based immuno-magnetic separation after one day and one week, as well as at the end of experiment in the other groups. Results: Quantifi ed CEC showed that there was a dose-dependent reduction in CEC count in group 1 (one week after irradiation) and group 2. A partial re-population of CEC was observed at the end of experiment in both group 1 and group 2 compared to control group. Group 3 showed a signifi cant increase in CEC levels as compared with group 2 without reaching the control level. Conclusion: The number of CEC (CD146 positive cells) in rats exposed to whole-body gamma irradiation was reduced in a dose-dependent manner and it partly recovered during the two-month interval after irradiation. We suggest that CEC count may be an indicator of the radiation-induced vascular damage.

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Preclinical Research into Basic Mechanisms of Radiation-Induced Heart Disease

Cited by 73 publications

References 123 publications

Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique

Modulatory Role of Selenium Nanoparticles and Grape Seed Extract Mixture on Oxidative Stress Biomarkers in Diabetic Irradiated Rats.

Evaluation of circulating endothelial cells in the rat after acute and fractionated whole-body gamma irradiation

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