Precocious puberty and pineal cyst — an uncommon association

Kumar, K.V.S. Hari; Verma, Abhinov; Modi, Kirtikumar D; Rayudu, B. Ramasubba

doi:10.1007/s13312-010-0034-1

Cited by 18 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, human reproductive cycles are regulated by melatonin, a central gonadal inhibition hormone secreted from the pineal gland [ 2 – 4 ]. The pineal lesion could impact the structure and function of pineal gland, potentially affecting the level of melatonin and then causing central PP [ 5 – 13 ]. Consequently, pineal tumors may present PP via either damging the regulation of pineal and melatonin or mimicking LH funcion by circulating hCG.…”

Section: Introductionmentioning

confidence: 99%

Central precocious puberty secondary to peripheral precocious puberty due to a pineal germ cell tumor: a case and review of literature

Chen,

Mo,

Zhong

2023

BMC Endocr Disord

View full text Add to dashboard Cite

Background The pineal lesion affecting melatonin is a rare cause of central precocious puberty by decreasing the inhibition of hypothalamic–pituitary–gonadal axis. Germ cell tumor secreting human chorionic gonadotropin is a rare cause of peripheral puberty. Case presentation A 5.8-year-old male presented facial hair and phallic growth, deepened voice, and accelerated growth velocity for 6 months. The elevated human chorionic gonadotropin level with undetectable gonadotropin levels indicated peripheral precocious puberty. Brain imaging revealed a pineal mass and further pathology indicated the diagnosis of teratoma. During chemoradiotherapy with operation, the elevated human chorionic gonadotropin level reduced to normal range, while the levels of gonadotropins and testosterone increased. Subsequently, progressing precocious puberty was arrested with gonadotrophin-releasing hormone analog therapy. Previous cases of transition from peripheral precocious puberty to central precocious puberty were reviewed. The transitions were caused by the suddenly reduced feedback inhibition of sex steroid hormones on gonadotropin releasing hormone and gonadotropins. Conclusions For patients with human chorionic gonadotropin-secreting tumors, gonadotropin levels increase prior to sex steroid decrease, seems a sign of melatonin-related central PP related to melatonin.

show abstract