Precocious Puberty with Primary Hypothyroidism due to Autoimmune Thyroiditis

Abstract

Children with hypothyroidism generally have delayed pubertal development. Rare association with precocious puberty may occur especially in long standing untreated patients. The cardinal features of hypothyroidism induced pseudoprecocious pubertal development include thelarche, galactorrhoea & menarche . Other characteristic features are absence of sexual hair & retardation of linear growth. In this report a rare case of vaginal bleeding, large multicystic ovaries, precocious puberty, slow physical & mental growth in a seven and half years old girl with hypothyroidism due to autoimmune thyroiditis is described. It is important to recognize this syndrome because initiating simple thyroid hormone replacement completely resolves symptoms and hormone abnormalities, avoiding unnecessary investigations for malignancies or surgical intervention.J Bangladesh Coll Phys Surg 2016; 34(1): 45-47

Pediatric Myxedema Due to Autoimmune Hypothyroidism: A Rare Complication of a Common Disorder

“…In our patient, pubertal development was age-appropriate. Children with hypothyroidism generally have delayed puberty; in rare cases of long-lasting untreated hypothyroidism, precocious puberty secondary to hyperprolactinemia or increased TSH levels [ 7 , 8 ] has also been reported.…”

Precocious Puberty as a Result of Congenital Hypothyroidism

“…The cause of vaginal bleeding must be sought when bleeding occurs in young girl, like in this case, and clinical presentation may Hypothyroidism associated with paradoxical precocious puberty was first described by Kendle in 1905 [5,8]. Bone age was estimated at was 2 year and 9 months using the Greulich and Pyle method.…”