Precocious weaning and changes in social variables during prepuberty affect cocaine reinforcing properties in adult mice

Laviola, Giovanni; Dell’Omo, Giacomo

doi:10.3758/bf03331923

Cited by 16 publications

(2 citation statements)

References 45 publications

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“…As expected on the basis of previous experiments (e.g., Laviola & Dell'Omo, 1997; Loggi, Dell'Omo, & Laviola, 1996), no differences in adult body weight were associated to either the PSS or the weaning variable.…”

Section: Resultssupporting

confidence: 88%

Attractivity and social preferences in mice (Mus musculus domesticus): The role of prepubertal sexual segregation and of precocious weaning.

Terranova¹,

Loggi²,

Chiarotti³

et al. 2000

Journal of Comparative Psychology

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Mice (Mus musculus domesticus) were raised (Postnatal Day 15 to 25) in single- or mixed-sex litters and precociously (Day 15) or regularly (Day 25) weaned. When they were faced as adults with a basic social choice--between two stimulus mice raised in litters of different sex composition but both of the same sex as the chooser--mice raised in mixed-sex litters were preferred. In the sociosexual choice-between a male and a female, both from the single- or the mixed-sex group--the opposite-sex preference was expressed. Both these preferences were abolished by the sexual segregation of the choosers. This variable hardly affected potential mate choice--between two stimulus mice both of the opposite sex of the chooser but raised in litters of different sex composition. Data indicate that socially mediated behavioral plasticity has a major role in the early shaping of adult individual differences both in attractive stimulus properties and in sociosexual preferences.

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Section: Resultssupporting

confidence: 88%

Attractivity and social preferences in mice (Mus musculus domesticus): The role of prepubertal sexual segregation and of precocious weaning.

Terranova¹,

Loggi²,

Chiarotti³

et al. 2000

Journal of Comparative Psychology

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“…After approximately 2 weeks, the male was removed, and the females were housed individually and inspected daily for delivery. The day after delivery, litters were culled to 6 males and 3 females to avoid potential carryover effects of rearing animals in a sexually segregated condition during the preweaning period (Laviola & Dell'Omo, 1997). On Postnatal Day (PND) 21, mouse pups were weaned, and 3 littermates were housed in each Plexiglas cage (33 × 13 × 14 cm), according to sex.…”

Section: Methodsmentioning

confidence: 99%

Elevated novelty seeking and peculiar d-amphetamine sensitization in periadolescent mice compared with adult mice.

Adriani¹,

Chiarotti²,

Laviola³

1998

Behavioral Neuroscience

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Novelty seeking as well as amphetamine sensitization were studied in adult (postnatal day "PND" > 60) and periadolescent (PND 3343) mice treated with saline or amphetamine (2 or 10 mg/kg once per day) for 3 days in a familiar environment. After a 48-hr wash-out period, mice were challenged with either saline or amphetamine (2 mg/kg) in the same environment. When given a choice, animals showed a preference for a novel environment, an effect more marked in periadolescents. Acute amphetamine strongly increased novelty seeking in adults, whereas it had an opposite effect in periadolescents. Adult mice in the chronic amphetamine 2 group showed a conditioned preference for the drug-paired compartment, whereas an aversion characterized adult mice in the amphetamine 10 group. Periadolescents in the latter group exhibited a greater sensitization of the locomotor response, but did not show the compulsive licking typical of adults. This appears to be a useful model to study psychobiological risk factors involved in vulnerability to addiction during human adolescence.

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Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats

et al. 2005

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Precocious weaning and changes in social variables during prepuberty affect cocaine reinforcing properties in adult mice

Cited by 16 publications

References 45 publications

Attractivity and social preferences in mice (Mus musculus domesticus): The role of prepubertal sexual segregation and of precocious weaning.

Attractivity and social preferences in mice (Mus musculus domesticus): The role of prepubertal sexual segregation and of precocious weaning.

Elevated novelty seeking and peculiar d-amphetamine sensitization in periadolescent mice compared with adult mice.

Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats

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