Precordial ECG Amplitudes in the Days After Birth: Electrocardiographic Changes During Transition from Fetal to Neonatal Circulation

Hvidemose, Sara Osted; Pærregaard, Maria Munk; Pihl, Christian; Pietersen, Adrian; Iversen, Kasper; Bundgaard, Henning; Christensen, Alex Hørby

doi:10.1007/s00246-021-02547-8

Cited by 6 publications

(9 citation statements)

References 23 publications

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“…This method was specifically designed to assess the precision and reliability of molecular diagnostic approaches. The electrocardiographic transition from foetal to neonatal circulation was examined by Hvidemose et al (2021). The study focused on the alterations in R-and S-wave amplitudes in V1 and V6 over the initial four weeks of life.…”

Section: Studies Indirectly Relating To Newborn Body Weightmentioning

confidence: 99%

Impact of Digital Technology on the Accuracy and Reliability of Infant Weight Measurements Globally

Permana Sari,

Setyonugroho

2023

icohetech

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The research aimed to investigate the influence of digital technology on the precision, dependability, and ubiquity of baby weight measurements on a global scale. This encompassed a variety of studies assessing the accuracy of hospital registers and self-reported data, obstacles and facilitators associated with weighing at delivery, the correlation between ultrasonography estimated foetal weight and birth weight, and the impact of quality improvement efforts on birth weight data. Additionally, indirectly related studies were considered, examining gestational weight gain, physical activity during pregnancy, infant anthropometry, and infant feeding practices. The findings indicate that while there remain challenges such as access to precise instruments and sufficient healthcare personnel, digital technology advancements, including digital health interventions, mobile-based solutions, and digital electrocardiograms, have significantly contributed to improving birth weight data accuracy and low birth weight prevalence. Furthermore, these advancements have also positively impacted other related aspects, such as gestational weight gain and community-based malnutrition screening, which indirectly influence newborn weight and overall infant and child well-being. Overall, despite existing challenges and areas requiring further research, digital technology advancements have significantly improved baby weight measurements' precision, reliability, and ubiquity worldwide, contributing to better neonatal and pediatric healthcare.

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Section: Studies Indirectly Relating To Newborn Body Weightmentioning

confidence: 99%

Impact of Digital Technology on the Accuracy and Reliability of Infant Weight Measurements Globally

Permana Sari,

Setyonugroho

2023

icohetech

View full text Add to dashboard Cite

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“…Bacterial products and/or profibrous cytokines acting on cervical cells of the uterus may cause a change of MMPs expression. High concentrations MMP-8 of amniotic fluid are associated with PB (before the 32nd week of pregnancy) so induction of uterine contractions (directly or by functional "withdrawal" of progesterone) [50][51][52][53][54][55][56][57][58][59][60].…”

Section: Preterm Labor: the Mechanism Includesmentioning

confidence: 99%

“…The receptor antagonist of IL-1 inhibits the biological effects of IL-1, blocking its receptors. Consequently reduction of IL-1 production and induced from that of prostaglandin production by them endometrial tissue can prevent PB associated with infection Il-1β is found in chorionic villi, decidua, amniotic fluid and placental cultures [50][51][52][53][54][55][56][57][58][59][60]. Elevated levels of Il-6 are usually found in the amniotic fluid, with inflammation.…”

Section: Preterm Labor: the Mechanism Includesmentioning

confidence: 99%

“…The finding of extremelly high levels of the specific cytokine in the amniotic fluid pregnant women who presented with some kind of inflammation and its very low concentration in cases of PB "idiopathic" etiology, make it one of the most sensitive and specific PB indicators On the contrary, they were found to be reduced in cases of premature birth. Il-10 is also elevated in amniotic fluid after amniocentesis during the second trimester in pregnancies with IUGR and chorioamnionitis [50][51][52][53][54][55][56][57][58][59][60]. Interleukin-10 (IL-10) is known to be major inhibitory cytokine in the process synthesis of cytokines by both T cells (interferon-γ and IL-2), as well as by monocytes macrophages (TNF-α, IL-6, IL-8, and IL-12) and as therefore plays an important role in achieving the outcome of the pregnancy by securing the maternity tolerance to the allogeneic fetus.…”

Section: Preterm Labor: the Mechanism Includesmentioning

confidence: 99%

“…Interleukin-10 (IL-10) is known to be major inhibitory cytokine in the process synthesis of cytokines by both T cells (interferon-γ and IL-2), as well as by monocytes macrophages (TNF-α, IL-6, IL-8, and IL-12) and as therefore plays an important role in achieving the outcome of the pregnancy by securing the maternity tolerance to the allogeneic fetus. In most pregnancies IL-10 is detected in amniotic fluid Its high levels in amniotic fluid of pregnancies complicated with residual embryonic development as well as in cases of pregnant women with clinical symptoms chorioamnionitis associated with dysfunctional for immune activity in pregnancy and in PB [50][51][52][53][54][55][56][57][58][59][60].…”

Section: Preterm Labor: the Mechanism Includesmentioning

confidence: 99%

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Premature Birth, Management, Complications

Tsikouras¹,

Bothou²,

Gerede³

et al. 2021

Global Women's Health

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In recent years an increase in premature births (PB) rate has been noticed, as this pregnancy complication that still remain an important cause of perinatal morbidity and mortality, is multifactorial and prediction is not easy in many cases. There are many bibliographic data supporting the view that PB have also genetic predisposition. The trend of “recurrence” of PB in women as well as its increased frequency in ethnic groups suggests its association with genetic factors, either as such or as an interaction of genes and environment. Immunomodulatory molecules and receptors as well as polymorphisms of various genes and/or single nucleotides (single nucleotide polymorphisms, SNPs) now allow with advanced methods of Molecular Biology the identification of genes and proteins involved in the pathophysiology of PB. From the history of a pregnant woman, the main prognostic factor is a previous history of prematurity, while an ultrasound assessment of the cervix between 18 and 24 weeks is suggested, both in the developed and the developing world. According to the latest data, an effective method of successful prevention of premature birth has not been found. The main interventions suggested for the prevention of premature birth are the cervical cerclage, the use of cervical pessary, the use of progesterone orally, subcutaneously or transvaginally, and for treatment administration of tocolytic medication as an attempt to inhibit childbirth for at least 48 hours to make corticosteroids more effective. Despite the positive results in reducing mortality and morbidity of premature infants, the need for more research in the field of prevention, investigation of the genital code and the mechanism of initiation of preterm birth is important.

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The Neonatal QRS Complex and Its Association with Left Ventricular Mass

Molin,

Hartmann,

Pærregaard

et al. 2023

Pediatr Cardiol

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To evaluate QRS complex features during the first month of life and the association with echocardiographic measurements of left ventricular mass in neonates. Prospective cohort study of neonates with electrocardiography (ECG) and echocardiography performed during the first month of life. Left ventricular mass index (LVMI) was determined by echocardiography and the correlation with electrocardiographic markers of LVMI outliers (≥ 98th percentile) were analyzed. We included 17,450 neonates (52% boys; median age at examination 11 days) and found an increase in median QRS duration and LVMI during the first month of life (54 vs. 56 ms and 24.7 vs. 28.6 g/m2 at days 0–4 and 25–30, respectively; both p < 0.001). All investigated ECG features (QRS duration, QRS area in V1/V6, maximum amplitudes of S-V1/R-V6, and the Sokolow–Lyon voltage product) showed no to low correlation with LVMI, resulting in low sensitivities (0–9.0%), but high specificities (97.2–98.1%), and area under the curve values close to the identity line (0.49–0.61) for identifying LVMI outliers. Adjustment of outlier definition for LVMI and threshold for QRS features had no significant effect on sensitivity. We present reference values for QRS complex features and their association with LVMI in neonates from a large, unselected, population-based cohort. The QRS complex gradually evolved during the first month of life but had a low correlation with LVMI. Our results indicate a poor diagnostic value of using ECG features to identify LVMI outliers in neonates.Trial Registry Copenhagen Baby Heart, NCT02753348, https://clinicaltri-als.gov/ct2/show/NCT02753348?cond=Copenhagen+Baby+Heart&draw=2&rank=1, deidentified individual participant data will not be made available.

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Precordial ECG Amplitudes in the Days After Birth: Electrocardiographic Changes During Transition from Fetal to Neonatal Circulation

Cited by 6 publications

References 23 publications

Impact of Digital Technology on the Accuracy and Reliability of Infant Weight Measurements Globally

Impact of Digital Technology on the Accuracy and Reliability of Infant Weight Measurements Globally

Premature Birth, Management, Complications

The Neonatal QRS Complex and Its Association with Left Ventricular Mass

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