Precursor B cell lymphoblastic lymphoma presenting as a solitary bone tumor: a case report and review of the literature

Abstract

Precursor B cell lymphoblastic lymphoma (B-LBL) is quite uncommon and it usually manifests as an extranodal disease. Although B-LBL may present with bone involvement, it is a very rare manifestation of B-LBL as a primary solitary bone tumor. Here, we report a case of precursor B-LBL presenting with solitary bone tumor and a review of a total of seven adult patients reported previously in the literature. We described demographic and clinical characteristics of these patients with unique presentation and discussed treatment options. Unlike previous reports except one case, our patient underwent allogeneic stem cell transplantation (allo-SCT) due to refractory disease. She is alive without evidence of disease by the post-transplant 12th month. B-LBL has an aggressive clinical course in adult patients and allo-SCT may be the best treatment option.

Precursor B cell lymphoblastic lymphoma presenting as a primary solitary skull bone tumor

“…There are no sufficient data on optimal treatment for B-LBL patients, but long-term survival can be achieved by intensive chemotherapy protocols. [3] In our case, surgical removal combined with aggressive chemotherapy was effective to treat.…”

Successful Treatment for Adult Precursor B-Cell Lymphoblastic Lymphoma Involving Central Nervous System Monitored by 18F-Fluorodeoxyglucose PET/CT Imaging

“…PBLL only accounts for 10-25% of all PLL and typically presents with subcutaneous, soft tissue, bone, and lymph node disease in children or young adults. Primary uncommon lesions of PBLL in testicles, localized skin, pancreas, and musculoskeletal system on 18 F-FDG PET imaging were reported, with SUV max ranging from 3.7 to 19.1 (3)(4)(5)(6)(7)(8)(9). Besides that, there are also case reports with initial symptoms of ovaries, retroperitoneum, tonsil, uterus, stomach, colon, mediastinum, and both lytic and blastic bone lesions (10)(11)(12)(13).…”

Precursor B-cell lymphoblastic lymphoma of oral cavity: A case report with its diagnostic workup

“…[ 1 ] Precursor B-LBL, forms 10% of LBL and is a rare subtype of non-Hodgkin's lymphoma (NHL). [ 2 3 ] It is a high-grade malignancy first described by Sternberg in 1916. [ 4 5 ] In 1975, Barcos and Lukes defined this pathological entity as LBL.…”