Precursors of Early Gastric Cancer

Nagayo, Takeo

doi:10.1007/978-3-642-70361-4_6

Cited by 3 publications

(1 citation statement)

References 131 publications

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“…Additionally, clinically relevant indicators are required for the delivery of xenobiotics. There currently limited data available due to the dearth of age-specific effectiveness and safety data in clinical trials (58). Elevated marker values are not due to the increased prevalence of chronic disease and not due to the presence or preclinical stage of occult malignancies, in most cases.…”

Section: Prognostic Predictive and Diagnostic Markersmentioning

confidence: 99%

Aging and cancer: Clinical role of tumor markers in the geriatric population (Review)

Sundaresan,

Rajapriya,

Lavanya

2024

Med Int

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Aging, with the progressive deterioration and functional decline of several organ systems, is highly heterogeneous for both between and within individuals. Tumor markers are widely used in clinical practice as a screening test for individuals >50 years of age. More specifically, caring for elderly patients is a public health concern, given the incidence of cancer and its related mortality and morbidity. A multidisciplinary diagnostic procedure known as a geriatric assessment is capable of identifying functional, psychological and physiological issues that are missed by standard evaluation. The present review focuses on cancers affecting the geriatric population, highlights current opportunities and challenges, and highlights the unmet need for clinically relevant tumor markers in elderly patients with cancer. A comprehensive geriatric examination, including a biological assessment, still requires conveniently available tumor markers and their levels in older populations in order to forecast deterioration or loss of functional balance. These tumor indicators ought to make it possible to track patients using other outcomes, such overall survival and functional impairment. Despite the notable progress made in the understanding of human biology, the mechanisms and networks underlying aging remain largely unknown. In addition, as elderly patients are a highly heterogeneous population, age-related changes cannot be distinguished solely by chronological age. Strong clinical studies, well-established protocols and meta-analyses may contribute to the better utilization of tumor biomarkers in the elderly population. Hence, the present review addresses the effects of aging on tumor markers and the usefulness of tumor marker values for the geriatric population. Contents1. Introduction 2. Biological aging and cancer tumor markers 3. Tumor markers and the elderly 4. Prognostic, predictive and diagnostic markers 5. Genomic instability in aging cells 6. Age-stratified and sex-specific reference intervals 7. Conclusion and future perspectives

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Section: Prognostic Predictive and Diagnostic Markersmentioning

confidence: 99%

Aging and cancer: Clinical role of tumor markers in the geriatric population (Review)

Sundaresan,

Rajapriya,

Lavanya

2024

Med Int

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Gastric intestinal metaplasia type III cases are classified as low‐grade dysplasia on the basis of morphometry

Tosi

Filipe

Luzi

et al. 1993

The Journal of Pathology

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The aim of this study was to try to place gastric intestinal metaplasia, type III (type III IM) in the stepwise chain of events from atrophic gastritis to cancer. A number of dysplastic, periulcer regenerative, and type III IM lesions were qualitatively diagnosed (and graded) blindly and independently by several pathologists. These lesions were further analysed by means of quantitative parameters, with the aim of differentiating dysplastic from regenerative changes. Inconsistencies between the qualitative and quantitative classification (about 7 per cent of cases) were eliminated and homogeneous groups (low-grade dysplasia, high-grade dysplasia, regenerative changes) were obtained. These cases were taken as the gold standard against which type III IM was compared. The results indicate that the great majority (91.4 per cent) of cases of type III IM fulfil the nuclear and architectural criteria for low-grade dysplasia.

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Gastric Polyps and Gastric Carcinoma

Ming

1993

Precancerous Conditions and Lesions of the Stomach

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Precursors of Early Gastric Cancer

Cited by 3 publications

References 131 publications

Aging and cancer: Clinical role of tumor markers in the geriatric population (Review)

Aging and cancer: Clinical role of tumor markers in the geriatric population (Review)

Gastric intestinal metaplasia type III cases are classified as low‐grade dysplasia on the basis of morphometry

Gastric Polyps and Gastric Carcinoma

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