Predation Efficacy of &lt;i&gt;Bdellovibrio bacteriovorus&lt;/i&gt; on Multidrug-Resistant Clinical Pathogens and Their Corresponding Biofilms

Sun, Yao; Ye, Jianzhong; Hou, Yuanbo; Chen, Huale; Cao, Jianming; Zhou, Tieli

doi:10.7883/yoken.jjid.2016.405

Cited by 48 publications

(27 citation statements)

References 26 publications

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“…Assessment of safety, functionality, and stability are the first points to consider for a microorganism in terms of its use as a probiotic. In vitro studies on the potential inflammatory or cytotoxic effects of predators with several different mammalian cell lines showed that B. bacteriovorus does not seem to induce a strong inflammatory response [ 74 ], with no significant alterations in cytokine levels [ 111 , 112 ] and no effect on cell viability [ 105 ]. In vivo experiments showed the nontoxicity of Bdellovibrios [ 113 , 114 , 115 , 116 , 117 , 118 , 119 ] on several animal models.…”

Section: Discussionmentioning

confidence: 99%

“…Sun and collaborators examined the ability of B. bacteriovorus to prey on multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative clinical bacteria like Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumanni, and Pseudomonas aeruginosa in sessile and planktonic culture. B. bacteriovorus 109J was found to be able to prey on all planktonic cultures tested, with the most efficient predation observed for drug-resistant E. coli, which demonstrated a promising efficacy in preventing biofilm formation [111]. Recently, it was demonstrated that B. bacteriovorus is also able to prey on the Burkholderia cepacia complex, suggesting its utility in the biocontrol of both human and plant pathogens [112].…”

Section: Potential Therapeutic Usementioning

confidence: 99%

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Insight into the Possible Use of the Predator Bdellovibrio bacteriovorus as a Probiotic

et al. 2020

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The gut microbiota is a complex microbial ecosystem that coexists with the human organism in the intestinal tract. The members of this ecosystem live together in a balance between them and the host, contributing to its healthy state. Stress, aging, and antibiotic therapies are the principal factors affecting the gut microbiota composition, breaking the mutualistic relationship among microbes and resulting in the overgrowth of potential pathogens. This condition, called dysbiosis, has been linked to several chronic pathologies. In this review, we propose the use of the predator Bdellovibrio bacteriovorus as a possible probiotic to prevent or counteract dysbiotic outcomes and look at the findings of previous research.

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Section: Discussionmentioning

confidence: 99%

Section: Potential Therapeutic Usementioning

confidence: 99%

Insight into the Possible Use of the Predator Bdellovibrio bacteriovorus as a Probiotic

et al. 2020

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“…Of special interest is the ability of BALOs to disrupt biofilms of medically relevant pathogens (Sun et al, 2017), as well as possibility to use them synergistically with certain antibiotics (e.g., ciprofloxacin) (Chanyi et al, 2016). However, the removal of environmental and industrial biofilms with BALOs has also been carefully investigated.…”

Section: Balos Regulation Of Prey and Non-prey Biofilmsmentioning

confidence: 99%

Biotechnological Potential of Bdellovibrio and Like Organisms and Their Secreted Enzymes

et al. 2020

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Bdellovibrio and like organisms (BALOs) are obligate predatory bacteria that selectively prey on a broad range of Gram-negative bacteria, including multidrug-resistant human pathogens. Due to their unique lifestyle, they have been long recognized as a potential therapeutic and biocontrol agent. Research on BALOs has rapidly grown over the recent decade, resulting in many publications concerning molecular details of bacterial predation as well as applications thereof in medicine and biotechnology. This review summarizes the current knowledge on biotechnological potential of obligate predatory bacteria and their secreted enzymes.

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“… B. bacteriovorus successfully reduce pathogen numbers in both laboratory buffer and human serum [68] and against prey in biofilms [69–71], which are often recalcitrant to antibiotic treatment [72]. Importantly, a number of multi-drug-resistant human clinical isolates have been shown to be susceptible to predation by B.…”

Section: Examining the Prey Range Of B Bacteriovorus : In Vitro Amentioning

confidence: 99%

Predatory bacteria as living antibiotics – where are we now?

Atterbury

Tyson

2021

Microbiology

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Antimicrobial resistance (AMR) is a global health and economic crisis. With too few antibiotics in development to meet current and anticipated needs, there is a critical need for new therapies to treat Gram-negative infections. One potential approach is the use of living predatory bacteria, such as Bdellovibrio bacteriovorus (small Gram-negative bacteria that naturally invade and kill Gram-negative pathogens of humans, animals and plants). Moving toward the use of Bdellovibrio as a ‘living antibiotic’ demands the investigation and characterization of these bacterial predators in biologically relevant systems. We review the fundamental science supporting the feasibility of predatory bacteria as alternatives to antibiotics.

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Predation Efficacy of <i>Bdellovibrio bacteriovorus</i> on Multidrug-Resistant Clinical Pathogens and Their Corresponding Biofilms

Cited by 48 publications

References 26 publications

Insight into the Possible Use of the Predator Bdellovibrio bacteriovorus as a Probiotic

Insight into the Possible Use of the Predator Bdellovibrio bacteriovorus as a Probiotic

Biotechnological Potential of Bdellovibrio and Like Organisms and Their Secreted Enzymes

Predatory bacteria as living antibiotics – where are we now?

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