Prediabetes and impaired lung function in asymptomatic adults

Li, Yulan; Saito, Masafumi; Tobimatsu, Satoshi; Oshida, Haruki; Hori, Yumiko; Fuchigami, Hiroshi; Munakata, Hiromi; Nakajima, Kei

doi:10.1016/j.diabres.2013.01.021

Cited by 11 publications

(12 citation statements)

References 10 publications

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“…The diabetic and IGT groups were older in age in comparison with the normal healthy group, as shown in Table 1, aconstant observation in previous studies as stated by Li, Saito et al [36], old age is a non-modifiable risk factor for CVD and other diseases related to aging, IGT and type-2 diabetes are correlated with older ages. In the present study,Ox-LDL was found to be increased with age, the Pearson correlation coefficient ( r = 0.422) between age and Ox-LDL in the whole subjects was found to be significant P < 0.001.…”

Section: Discussionmentioning

confidence: 54%

Oxidized low density lipoprotein and total antioxidant capacity in type-2 diabetic and impaired glucose tolerance Saudi men

Eldin

Almarzouki

Assiri

et al. 2014

Diabetol Metab Syndr

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BackgroundOxidative modification of low density lipoproteins (LDL) convert these native particles into pathogenic, immunogenic and atherogenic particles. Factors enhance LDL oxidation are poorly understood, especially in conditions of hyperglycemia. The present study was conducted to investigate which metabolic conditions are associated with the promotion of LDL oxidation in different glycemic situations.MethodsAdult male participants (274) were selected from patients admitted to the outpatient department of Diabetes Center in Al-Noor Specialized Hospital in Makkah and other citizens and residents in the city. The studied group was classified into three sub-groups: Group-I: control group of non-diabetic normal subjects, Group-II: subjects with impaired glucose tolerance (IGT) and Group-III: cases of type-2 diabetes mellitus (DM). Measurement of fasting blood glucose, 2 hour post-prandial blood glucose, glycosylated hemoglobin (HbA1c), triglycerides, serum cholesterol, HDL-cholesterol, LDL-cholesterol, ox-LDL, Total Antoxidant capacity (TAC) and Malondialdehyde (MDA) were performed. The obtained results were statistically analyzed.ResultsOxidation of native LDL increase nearly two folds in Type-2 DM group compared to controls. There is also significant increase in Ox-LDL of IGT group compared to controls. The correlation between Ox-LDL concentration and HbA1c in the whole population of the study confirms the increased Ox-LDL in subjects with hyperglycemia. A negative correlation exists between the concentration of Ox-LDL and total antioxidant capacity (TAC) in each studied group and in the whole population of the study as well. A positive correlation also exists between Ox-LDL concentrations and LDL values, more clear in controls and Type-2 DM, while this correlation was not significant in IGT group. The ratio of LDL oxidation as expressed by ox-LDL/LDL was increased in IGT group compared to control. More significant increase was observed in type-2 DM group.ConclusionWe concluded that the concentration of Ox-LDL increased in subjects with type-2 DM and IGT compared to controls. Moreover, oxidation of native LDL was associated with low levels of TAC and positively correlated with LDL levels, total cholesterol, HbA1c, body mass index (BMI) and increased age.

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Section: Discussionmentioning

confidence: 54%

Oxidized low density lipoprotein and total antioxidant capacity in type-2 diabetic and impaired glucose tolerance Saudi men

Eldin

Almarzouki

Assiri

et al. 2014

Diabetol Metab Syndr

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“…Evidence suggests, however, that clinical complications occur when this condition is present, including reduced lung function (Li et al. ), neuropathy (Divisova et al. , Bongaerts et al.…”

Section: Discussionmentioning

confidence: 99%

Periodontal findings in individuals with newly identified pre‐diabetes or diabetes mellitus

Lamster

Cheng

Burkett

et al. 2014

J Clinic Periodontology

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“…Leone et al found that all individual factors of MS were related to lung function impairment in adults with a mean age of 45 in France [ 19 ]. In a study sample of similar age range than that of the Limache Cohort, Li et al found that ‘pre-diabetes’ risk factors such as elevated fasting glucose and insulin resistance were associated with lower FVC [ 30 ]. Several studies have found a positive association between waist circumference with lung function, and other epidemiological studies have reported no association in relation to lung function or lung function decline in people with mild COPD [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Ventilatory function and cardiovascular disease risk factors: a cross-sectional study in young adults

et al. 2014

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BackgroundThe association between impaired lung function and cardiovascular disease (CVD) risk factors has been shown in adults. However, there is little evidence of such an association in young adults, particularly from South America, where the burden of CVD and chronic obstructive pulmonary disease (COPD) is as high as that observed in more developed countries. We therefore investigated the relation between CVD risk factors including metabolic syndrome (MS), and lung function status in young adults from Chile.Methods970 subjects from a sample of 998 adults born between 1974 and 1978 in Limache, Chile, were studied. A Spanish translation of the European Community Respiratory Health Survey (ECRHS) questionnaire was used. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were measured. Weight, height, waist circumference (WC), blood pressure, Homeostatic model assessment (HOMA-IR), triglycerides, high density lipoprotein (HDL), glycaemia, and metabolic syndrome (MS) were also assessed.ResultsThe prevalence of MS was 11.8%. A lower FEV1 and lower FVC were associated with having MS (β-coefficient -0.13; 95% Confidence Interval [CI] -0.21 to -0.05, and β-coefficient -0.18; 95% CI -0.27 to -0.09, respectively). Both spirometric measures were also negatively associated with having an elevated HOMA-IR (β-coefficient for FEV1 -0.08; 95% CI -0.13 to -0.03, and β-coefficient for FVC -0.11; 95% CI -0.17 to -0.05). In males only, a lower FEV1 and FVC were associated with having elevated triglycerides (β-coefficient highest vs. lowest tertile -0.13, 95% CI -0.24 to -0.03, and β-coefficient -0.13, 95% CI -0.25 to -0.01, respectively). In women, a higher FEV1 and FVC were statistically significantly related to having higher levels of HDL. Ventilatory function was unrelated to hypertension or WC in this population.ConclusionIn this population-based study of young adults, a poorer ventilatory function was associated with many CVD risk factors. Endeavours to understand better causality issues of such associations are warranted.

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Prediabetes and impaired lung function in asymptomatic adults

Cited by 11 publications

References 10 publications

Oxidized low density lipoprotein and total antioxidant capacity in type-2 diabetic and impaired glucose tolerance Saudi men

Oxidized low density lipoprotein and total antioxidant capacity in type-2 diabetic and impaired glucose tolerance Saudi men

Periodontal findings in individuals with newly identified pre‐diabetes or diabetes mellitus

Ventilatory function and cardiovascular disease risk factors: a cross-sectional study in young adults

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