Prediabetes and poorly controlled type-2 diabetes as risk indicators for peri-implant diseases:A systematic review and meta-analysis

Bencze, Bulcsú; Cavalcante, Bianca Golzio Navarro; Romandini, Mario; Róna, Virág; Váncsa, Szilárd; Varga, Gábor; Kivovics, Márton; Szabó, Bence; Agócs, Gergely; Géczi, Zoltán; Hermann, Péter; Hegyi, Péter; Végh, Dániel

doi:10.1016/j.jdent.2024.105094

Cited by 2 publications

(1 citation statement)

References 99 publications

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“…There is already evidence in the literature, that poor glycemic control in patients with type 2 DM elevates the risk of caries, periodontitis and peri-implantitis, however there were no previous analysis in the matter that investigated children with type 1 DM [ 69 – 71 ]. In order to fill this gap, we conducted the necessary analyses and found statistically significant, and clinically relevant differences between GGC and PGC children.…”

Section: Discussionmentioning

confidence: 99%

Poor glycemic control impairs oral health in children with type 1 diabetes mellitus - a systematic review and meta-analysis

Triebl,

Bencze,

Bányai

et al. 2024

BMC Oral Health

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Objective There are more than one million children and adolescents living with type 1 diabetes mellitus, and their number is steadily increasing. Diabetes affects oral health through numerous channels, including hyposalivation, immune suppression, and the inflammatory effect of glycation end-products. However, patients with type 1 diabetes must follow a strict sugar free diet that is proven to be carioprotective. Therefore, the aim of this systematic review and meta-analysis is to investigate whether children with type 1 diabetes have a difference in Decayed, Missing, Filled Teeth index (DMFT), salivary function, and periodontal status than children without diabetes, with an emphasis on glycemic control. Materials and Methods PubMed, Embase and Cochrane libraries were screened for articles, using predefined search keys without any language or date restrictions. Two independent authors performed the selection procedure, extracted data from the eligible articles, carried out a manual search of the reference lists, and assessed the risk of bias using the Newcastle-Ottawa scale. Meta-analysis was performed in R using the random-effects model. Effect sizes were mean differences; subgroup analysis was performed on glycemic control. Results 33 studies satisfied the eligibility criteria. 22 studies did not show a significant difference regarding the DMFT index between the diabetes and non-diabetes groups; six studies found that children living with diabetes had higher DMFT scores, compared to five studies that found significantly lower scores. Meta-analysis found no statistically significant differences in plaque, gingival, and calculus indexes, however it found significant differences in pooled DMFT indexes, and salivary flow rate. Subgroup analysis on glycemic control using DMFT values found significant differences in children with good and poor glycemic control with results of 0.26 (CI95%=-0.50; 1.03) and 1.46 (CI95%=0.57; 2.35), respectively. Conclusions Children with poor glycemic control face higher risk of developing caries compared to good control and non-diabetes children. Regular dental check-ups and strict control of glycemic levels are highly advised for children living with type 1 diabetes, further emphasizing the importance of cooperation between dentists and diabetologists.

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Section: Discussionmentioning

confidence: 99%

Poor glycemic control impairs oral health in children with type 1 diabetes mellitus - a systematic review and meta-analysis

Triebl,

Bencze,

Bányai

et al. 2024

BMC Oral Health

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Soft‐Tissue Phenotype as a Risk Indicator of Peri‐Implantitis and Peri‐Implant Soft‐Tissue Dehiscence—A Cross‐Sectional Study

Isler,

Romandini,

Akca

et al. 2024

J Clinic Periodontology

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AimTo investigate the association, as well as to characterize the associated panel of pro‐ and anti‐inflammatory markers, between the different components of the peri‐implant phenotype and the presence of peri‐implantitis/peri‐implant soft‐tissue dehiscence (PISTD).Materials and MethodsA total of 324 implants in 112 patients were included. The following components of the peri‐implant phenotype were clinically measured through the use of a manual periodontal probe or a digital calliper: keratinized mucosa width (PIKM‐W), mucosal thickness (MT), attached mucosa (AM) and vestibulum depth (VD). The presence of peri‐implantitis and PISTD was assessed through clinical and radiographic examination. Mixed‐models logistic regression analyses were performed to analyse the association between peri‐implant phenotype and the presence of peri‐implantitis or PISTD, adjusting for relevant confounders. Multiplex immunoassays were employed to evaluate the peri‐implant crevicular fluid levels of a panel of pro‐ and anti‐inflammatory markers.ResultsPeri‐implant health, peri‐implant mucositis and peri‐implantitis were diagnosed in 36.6%, 21.4% and 42% of the patients (classified according to their worst implant) and 35.2%, 34.3%, and 30.5% of the implants, respectively. In the multi‐level multiple regression model, the absence of PIKM‐W (odds ratio [OR] = 9.24; 95% CI: 2.73–31.28), the absence of attached mucosa (OR = 19.58; 95% CI: 6.12–62.56) and a reduced (<4 mm) vestibulum depth (OR = 2.61; 95% CI: 1.05–6.48) were associated with peri‐implantitis. Similarly, the absence of PIKM‐W (OR = 6.32; 95% CI: 1.67–23.83), a thin (<2 mm) mucosa (OR = 157.75; 95% CI: 14.06–1769.9) and a reduced vestibulum depth (OR = 3.32; 95% CI: 1.02–10.84) were associated with the presence of PISTD. Implants with PIKM‐W = 0 mm showed statistically significantly higher levels of interferon‐γ in both regular (≥2 maintenance/year) and irregular (<2 maintenance/year) compliers (p = 0.046 and p = 0.012). In irregular compliers, the absence of PIKM‐W was also associated with statistically significantly higher levels of interleukin (IL)‐1β and IL‐21 (p = 0.016, p = 0.046). These associations were independent of the effect of relevant confounders (e.g., plaque, compliance with maintenance, etc.).ConclusionsWithin their limits, the present findings indicate that (a) peri‐implant soft‐tissue phenotype appears to be associated with the presence of peri‐implantitis and PISTD, and (b) in the absence of PIKM‐W, the inflammatory response seems to be dysregulated and the soft‐tissue remodelling up‐regulated.

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Prediabetes and poorly controlled type-2 diabetes as risk indicators for peri-implant diseases:A systematic review and meta-analysis

Cited by 2 publications

References 99 publications

Poor glycemic control impairs oral health in children with type 1 diabetes mellitus - a systematic review and meta-analysis

Poor glycemic control impairs oral health in children with type 1 diabetes mellitus - a systematic review and meta-analysis

Soft‐Tissue Phenotype as a Risk Indicator of Peri‐Implantitis and Peri‐Implant Soft‐Tissue Dehiscence—A Cross‐Sectional Study

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