Predicted UV-C Sensitivity of Human and Non-human Vertebrate (+) ssRNA Viruses

Abstract

Epidemic and pandemic infectious diseases caused by RNA viruses constitute a significant hazard to human and animal health. Disinfection is an essential aspect of infection prevention and control measures. In this study, we estimated UV-C sensitivity of 83 human and veterinary pathogenic (+) ssRNA viruses by developed pyrimidine dinucleotide frequency-based genomic model. The data showed that the avian infectious bronchitis virus (genus: γ-coronavirus) with an estimated D90 value of 17.8 J/m2 was highly UV sensitive, whereas Salivirus NG-J1 (genus: salivirus) with a D90 value of 346.4 J/m2 was highly UV resistant. Overall, the trend of UV-C sensitivity of (+) ssRNA virus families followed as Coronaviridae < Flaviviridae < Togadoviridae < Arteriviridae, Matonaviridae, Astroviridae < Caciviridae < Picornaviridae < Nodaviridae < Herpeviridae. The results revealed that the enveloped viral families (Coronaviridae, Flaviviridae, Togadoviridae Arteriviridae, and Matonaviridae) are more UV-C sensitive than other non-enveloped families. Further validation of the model estimated UV sensitivity with literature available experimental data showed good agreement of predicted values. The estimates presented here could make it possible to reasonably predict UV-C disinfection efficiency of human and veterinary pathogenic viruses, which need specific biosafety requirements and/or difficult to cultivate in lab conditions.

Effect of germicidal short wave-length ultraviolet light on the polyphenols, vitamins, and microbial inactivation in highly opaque apple juice

“…From the optical data (Table 2), it may be seen that the apple juice was a strong absorber (7.98 cm - 1 ) of UV-C light. On the contrary, some fluids have absorbance between value 0.1 to 22 (Patras et al, 2020; Pendyala et al, 2021; Vashisht et al, 2022). Figure 1 illustrates the ultraviolet (UV) Spectra of apple juice at 254, 263, and 279 nm wavelengths.…”

Effect of germicidal short wavelength ultraviolet light on the polyphenols, vitamins, and microbial inactivation in a highly opaque apple juice

“…From the optical data (Table 2), it may be seen that the AJ was a strong absorber (7.98 cm −1 ) of UV‐C light. On the contrary, some beverages including coconut water, watermelon juice, and milk have absorbances between value 0.1 and 22 (Patras et al, 2020; Pendyala & Patras, 2021; Vashisht, Pendyala, Patras, Gopisetty, & Ravi, 2022). Figure 1 demonstrates a schematic diagram of collimated LED unit operating at 263 nm wavelength, with all functional parts included.…”