Predicting Alcohol Use From Genome-Wide Polygenic Scores, Environmental Factors, and Their Interactions in Young Adulthood

Kandaswamy, Radhika; Allegrini, Andrea; Nancarrow, Alexandra F.; Cave, Sophie Nicole; Plomin, Robert; Stumm, Sophie von

doi:10.1097/psy.0000000000001005

Cited by 8 publications

(2 citation statements)

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“…Most behavioral GxE research using polygenic scores has involved adult psychiatric disorders, although no solidly replicated GxE findings have emerged as yet (e.g., Arnau-Soler et al, 2019;Bogdan et al, 2018;Colodro-Conde et al, 2018;Kandaswamy et al, 2021;Robinson & Bergen, 2021). Reports of GxE in developmental psychopathology are beginning to emerge.…”

Section: Stagementioning

confidence: 99%

Gene–environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?

et al. 2022

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The DNA revolution has energized research on interactions between genes and environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors of behavioral traits. Here, we test the extent to which polygenic scores for attention-deficit/hyperactivity disorder and neuroticism moderate associations between parent reports of their children’s environmental risk (E) at ages 3 and 4 and teacher ratings of behavior problems (hyperactivity/inattention, conduct problems, emotional symptoms, and peer relationship problems) at ages 7, 9 and 12. The sampling frame included up to 6687 twins from the Twins Early Development Study. Our analyses focused on relative effect sizes of G, E and GxE in predicting behavior problems. G, E and GxE predicted up to 2%, 2% and 0.4%, respectively, of the variance in externalizing behavior problems (hyperactivity/inattention and conduct problems) across ages 7, 9 and 12, with no clear developmental trends. G and E predictions of emotional symptoms and peer relationship problems were weaker. A quarter (12 of 48) of our tests of GxE were nominally significant (p = .05). Increasing the predictive power of G and E would enhance the search for GxE.

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Section: Stagementioning

confidence: 99%

Gene–environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?

et al. 2022

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“…While some studies do find significant G x E effects (43,44), other studies fail to detect G x E moderation effects on self-control related traits (e.g. [45][46][47][48]. This and other research (e.g., 49) suggest that consistently identifying gene-environment (G x E) interactions for the prediction of complex traits, which are shaped by numerous genetic and environmental factors, is challenging.…”

Section: Discussionmentioning

confidence: 96%

No gene by stressful life events interaction on individual differences in adults’ self-control

Willems,

Raffington,

Ligthart

et al. 2024

Front. Psychiatry

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BackgroundDifficulty with self-control, or the ability to alter impulses and behavior in a goal-directed way, predicts interpersonal conflict, lower socioeconomic attainments, and more adverse health outcomes. Etiological understanding, and intervention for low self-control is, therefore, a public health goal. A prominent developmental theory proposes that individuals with high genetic propensity for low self-control that are also exposed to stressful environments may be most at-risk of low levels of self-control. Here we examine if polygenic measures associated with behaviors marked by low self-control interact with stressful life events in predicting self-control.MethodsLeveraging molecular data from a large population-based Dutch sample (N = 7,090, Mage = 41.2) to test for effects of genetics (i.e., polygenic scores for ADHD and aggression), stressful life events (e.g., traffic accident, violent assault, financial problems), and a gene-by-stress interaction on self-control (measured with the ASEBA Self-Control Scale).ResultsBoth genetics (β =.03 -.04, p <.001) and stressful life events (β = .11 -.14, p <.001) were associated with individual differences in self-control. We find no evidence of a gene-by-stressful life events interaction on individual differences in adults’ self-control.ConclusionOur findings are consistent with the notion that genetic influences and stressful life events exert largely independent effects on adult self-control. However, the small effect sizes of polygenic scores increases the likelihood of null results. Genetically-informed longitudinal research in large samples can further inform the etiology of individual differences in self-control from early childhood into later adulthood and its downstream implications for public health.

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Investigating the Biology of Behavioural Differences

Stevenson

2023

Developmental Psychopathology

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Predicting Alcohol Use From Genome-Wide Polygenic Scores, Environmental Factors, and Their Interactions in Young Adulthood

Abstract: Supplemental digital content is available in the text.

Cited by 8 publications

References 40 publications

Gene–environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?

Gene–environment interaction using polygenic scores: Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems?

No gene by stressful life events interaction on individual differences in adults’ self-control

Investigating the Biology of Behavioural Differences

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