Predicting Coronary Heart Disease in Siblings—a Multivariate Assessment

Snowden, Cecelia B.; McNamara, Patricia; Garrison, Robert J.; Feinleib, Manning; Kannel, William B.; Epstein, Frederick H.

doi:10.1093/oxfordjournals.aje.a113293

Cited by 114 publications

(33 citation statements)

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“…Family history of coronary artery disease (FHxCAD) is an established risk factor for the development of acute myocardial infarction (AMI) (1). However, data relating to impact of FHxCAD on post-ST-segment myocardial infarction (STEMI) clinical outcomes is limited (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Agarwal¹,

Garg²,

Lavie³

et al. 2018

Ann. Transl. Med.

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.001] when compared with no-FHxCAD group. They underwent a significantly higher number of coronary interventions, and were less likely to develop cardiogenic shock, acute cerebrovascular events and to require intra-aortic balloon pump during hospitalization.Conclusions: This large sample size study demonstrates that STEMI patients with FHxCAD had lower in-hospital mortality and adverse clinical events in comparison to patients with no-FHxCAD. Further research is warranted to determine whether the superior outcomes in FHxCAD patients with STEMI are related to differences in strategies related to diet, exercise, use of medications or coronary interventions.

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Section: Introductionmentioning

confidence: 99%

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Agarwal¹,

Garg²,

Lavie³

et al. 2018

Ann. Transl. Med.

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“…[1][2][3] Several studies have shown that family history (FHx) of CAD is strongly associated with incident cardiovascular disease, independent of traditional risk factors, and improves risk assessment. [4][5][6][7][8] Recently, genetic risk scores (GRSs) for CAD, consisting of specific genetic variants identified from genome-wide association studies, have also been associated with incident cardiovascular disease and have shown promise in improving cardiovascular risk prediction. [9][10][11][12][13][14][15][16][17][18][19][20][21][22] However, the exact predisposing mechanisms that account for the increased risk in patients with a FHx or a high GRS remain unclear.…”

mentioning

confidence: 99%

Association Between Family History, a Genetic Risk Score, and Severity of Coronary Artery Disease in Patients With Premature Acute Coronary Syndromes

Hindieh

Pilote

Cheema

et al. 2016

ATVB

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Objective-A genetic risk score (GRS) for coronary artery disease has recently been shown to be independent of family history (FHx) in predicting future cardiovascular events. We sought to determine whether the presence of these risk factors, either individually or together, was associated with a higher burden of angiographic coronary artery disease. Approach and Results-We included 763 patients with premature acute coronary syndrome (median age, 50 [46-53] years; 30.8% women) with at least 1 major epicardial vessel stenosis enrolled in the Gender and Sex Determinants of Cardiovascular Disease From Bench to Beyond in Premature Acute Coronary Syndrome (GENESIS-PRAXY) study, a multicentre prospective cohort study of premature patients with acute coronary syndrome (aged ≤55 years). Key Words: acute coronary syndrome ◼ atherosclerosis ◼ cohort studies ◼ coronary heart disease ◼ genetics ◼ myocardial infarction

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“…A recent study by Snowden et al 141 showed the concordance of CHD among the siblings of the Framingham Heart Study. The incidence of Ml in the older brothers was significantly related to the Ml experience of the younger brothers, even after the effects of total cholesterol, systolic blood pressure, and cigarette smoking were controlled in a multivariate analysis.…”

Section: Genetics and Multiple Risk Factorsmentioning

confidence: 98%

Genetic aspects of arteriosclerosis.

Goldbourt¹,

Neufeld²

1986

Arteriosclerosis

110

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Conclusions 372uals to CHD or atherosclerosis have not been defined. Current methods fall short of an ideal, but unfeasible, experimental set-up in which the results of genetic manipulation could be observed. Still, recent developments have augmented our knowledge to an important degree. During the past decade the discovery of restriction endonucleases and molecular cloning are revolutionizing gene mapping and the understanding of human anatomy and pathology at the DNA level. A recent interdisciplinary approach involving geneticists, epidemiologists, and clinicians has been instrumental in advancing our knowledge. In this review, we will assess the different types of evidence for the genetic determination of indicators of arteriosclerosis. We shall also discuss avenues of investigation that might lead us closer to the formidable, and so far elusive, task of disentangling the contributions of genetic and environmental causes of arteriosclerosis, its precursors, and its sequelae. Familial Aggregation of Coronary Heart DiseaseThe initial suggestion of genetic factors in the etiology of CHD came from findings of familial aggregation of the disease in a number of studies over the past 35 years. 8 ' 9 Research either centered around defined pedigrees or involved the large scale investigation of total communities including core families. One such example is the Tecumseh Study. 10 A significant early observation was made by Slack and Evans 11 who showed that among the relatives of 121 men and 96 women with CHD there was a sevenfold increase in mortality compared with the relatives of 104 male and 105 female controls.Other studies have also examined the risk factors among the first-degree relatives of persons afflicted with CHD in an effort to segregate the risk factors from the familial effect. An important study of familial aggregation was conducted by Rissanen 12 in North Karelia, Finland, and in a southern Finnish population. In North Karelia the CHD risk ratio was 3.5 for brothers of CHD index patients. The form of CHD in the proband brothers resembled that in the patients themselves, in both severity and in fatality. Among 1387 first-degree relatives of 203 male probands with confirmed myocardial infarction (Ml) and 692 relatives of 106 age-matched healthy controls, Rissanen 13 also showed that, for brothers of probands with early diagnosed Ml, a greater risk of CHD by age 55 years (elevenfold if Ml in the proband was established at or earlier than age 45I) was found in subjects from North Karelia than in those from the south (which was sevenfold). This was an important point in light of the notorious regional differences in CHD in Finland. The risk of the probands' brothers increased sharply with decreasing age at onset of disease in the probands. In addition to this most impressive familial aggregation of the disease, Rissanen also showed that hypertension and hyperiipidemia were most common among the relatives of the younger patients, although the contribution of these risk factors diminished with the advan...

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Predicting Coronary Heart Disease in Siblings—a Multivariate Assessment

Cited by 114 publications

References 0 publications

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Association Between Family History, a Genetic Risk Score, and Severity of Coronary Artery Disease in Patients With Premature Acute Coronary Syndromes

Genetic aspects of arteriosclerosis.

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