Predicting Factors for High-Grade Cervical Dysplasia in Women With Low-Grade Cervical Cytology and Nonvisible Squamocolumnar Junction

Bogani, Giorgio; Taverna, Francesca; Lombardo, Claudia; Ditto, Antonino; Martinelli, Fabio; Signorelli, Mauro; Chiappa, Valentina; Maggiore, Umberto Leone Roberti; Mosca, Lavinia; Sabatucci, Ilaria; Scaffa, Cono; Lorusso, Domenica; Raspagliesi, Francesco

doi:10.1177/1933719118756747

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…They included: the alpha‐5 type 51; alpha‐6 types 56 and 66; alpha‐7 types 18, 39, 45, and 59; and alpha‐9 types 16, 31, 33, 35, 52, and 58 . Although the majority of HPV infections resolve spontaneously, persistent HR‐HPV infection might cause precancerous and cancerous transformation of several types of epithelium …”

Section: Introductionmentioning

confidence: 99%

Cervical intraepithelial neoplasia in women who had vaccination against HPV

Bogani

Serati

Maggiore

et al. 2019

Intl J Gynecology & Obste

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Objective:To investigate the characteristics of women developing cervical intraepithelial neoplasia who had had a vaccination against human papillomavirus (HPV). Methods:A retrospective cohort study was carried out of women diagnosed with moderate or severe cervical dysplasia (CIN2+) in four Italian centers between 2015 and 2017. All women included had had previous bivalent or quadrivalent vaccination against HPV.Results: The present study included 43 patients affected by CIN2+. The median age was 28 (range, 21-41) years. Ten (23.3%) patients did not have a diagnosis of specific HPV type(s) involved: high-risk HPV was detected in 7 (16.3%) women while HPV testing was negative in 3 (6.9%) women. Lesions related to HPV16 were found in two patients.HPV types covered by nonavalent vaccination were diagnosed in 27/33 (81.8%) women.HPV types not covered by nonavalent vaccination were diagnosed in 6 (18.2%) women.Co-infections are most commonly detected in women with HPVs other than those included in the nonavalent vaccination (P=0.024). Conclusion:Cervical dysplasia occurring after HPV vaccination is a rare condition.Theoretically, nonavalent vaccination should improve protection against more than 80% of HPV-related lesions compared to other vaccines.

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Section: Introductionmentioning

confidence: 99%

Cervical intraepithelial neoplasia in women who had vaccination against HPV

Bogani

Serati

Maggiore

et al. 2019

Intl J Gynecology & Obste

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“…Other authors had far greater results than ours regarding women who had used tobacco in the past: Godfrey M.A.L et al [42] in the United Kingdom (41.9%), Pokomandy A et al [51] in Canada (54.1%); Agorastos A et al [52] in Greece (77.45%), Wudtisan J et al [35] in Thailand (26.7%) and Bogani G et al [53] in Italy (20.9%).…”

Section: Smoking Historymentioning

confidence: 47%

Epidemiological and Cytopathological Profile of Dysplastic Lesions of the Cervix in South-Kivu/Dr Congo

Nyakio¹,

Fabrice²,

Albert³

et al. 2021

OJOG

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Background: Cervical cancer is one of the most common cancers in women in the world. The recrudescence of dysplastic lesions is increasing, especially in developing countries, because of the absence of screening. The objective of this work is to determine the prevalence of dysplastic lesions of the cervix in women who are sexually active in South Kivu province. Methods: It was a cross-sectional, descriptive and analytical study of 625 women who came for gynecological consultation, all of whom had cervical-uterine Pap smears, during the period from January 1st, 2017 to December 31st, 2018 at Panzi General Referral Hospital (South Kivu, DR Congo). Data analysis was done using Epi Info software version 7. Results: The median age of the respondents was 34 years, 47.0% of them were married, and 59.0% had a low socioeconomic level. The majority had first sexual intercourse between the ages of 15 and 20 (67.5%), a number of former sexual partners estimated at 1-5 (87.8%), did not use tobacco (97.4%) and did not use contraception (78.1%). Pap smear was normal in 82.88% of cases, inflammatory in 2.4% of cases and with cytologic abnormalities in 14.72% of cases. Rates of dysplastic lesions were significantly higher among women aged ≥35 years (p = 0.0245), brides (p = 0.0183) and nulliparas (p = 0.0042). Multivariate analysis revealed the adjusted OR (95% CI) statistically insignificant (p < 0.05) for the age group, marital status and parity respondents. Conclusion: Cervical cancer How to cite this paper:

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Predicting Factors for High-Grade Cervical Dysplasia in Women With Low-Grade Cervical Cytology and Nonvisible Squamocolumnar Junction

Abstract: High-risk HPV persistence predicts the risk of developing CIN2+ in patients with unsatisfactory colposcopic examination. Further studies are warranted in order to implement the use of HPV testing in patients with unsatisfactory colposcopy.

Cited by 2 publications

References 14 publications

Cervical intraepithelial neoplasia in women who had vaccination against HPV

Cervical intraepithelial neoplasia in women who had vaccination against HPV

Epidemiological and Cytopathological Profile of Dysplastic Lesions of the Cervix in South-Kivu/Dr Congo

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