Predicting Isocitrate Dehydrogenase Mutation Status of Grade 2–4 Gliomas with Diffusion Tensor Imaging (DTI) Parameters Derived from Model-Based DTI and Model-Free Q-Sampling Imaging Reconstructions

Yüzkan, Sabahattin; Mutlu, Samet; Han, Moon Hee; Akkurt, Tuce Soylemez; Şencan, Fahir; Çabuk, Fatmagül Kuşku; Günaldı, Ömür; Tuğcu, Bekir; Koçak, Burak

doi:10.1016/j.wneu.2023.06.099

Cited by 1 publication

(3 citation statements)

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“…The radiologist was blinded to all clinical information of the patients during the analysis. DSI Studio software (Aug 30, 2021 build) was used to process diffusion imaging data using the DTI and GQI methods [ 43 , 44 ]. The diffusion data were reconstructed using GQI with a diffusion sampling length ratio of 1.25.…”

Section: Methodsmentioning

confidence: 99%

“…The diffusion data were reconstructed using GQI with a diffusion sampling length ratio of 1.25. Then, GQI metrics were obtained, in addition to DTI metrics [ 43 , 44 ]. The DTI metric used was fractional anisotropy (fa), while GQI metric was quantitative anisotropy (qa); representing the most commonly used metric for each technique [ 44 ].…”

Section: Methodsmentioning

confidence: 99%

“…Diffusion tensor imaging (DTI) and generalized q-sampling imaging (GQI) are two of the advanced magnetic resonance imaging (MRI) techniques that provide a non-invasive assessment of the microstructural integrity of the brain [ 36 , 44 ]. Previous DTI studies in PD have demonstrated abnormal metrics in multiple brain regions, particularly in the dopaminergic pathways [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

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Utility of diffusion tensor imaging and generalized q-sampling imaging for predicting short-term clinical effect of deep brain stimulation in Parkinson’s disease

Yuzkan,

Hasimoglu,

Balsak

et al. 2024

Acta Neurochir

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Purpose To assess whether diffusion tensor imaging (DTI) and generalized q-sampling imaging (GQI) metrics could preoperatively predict the clinical outcome of deep brain stimulation (DBS) in patients with Parkinson’s disease (PD). Methods In this single-center retrospective study, from September 2021 to March 2023, preoperative DTI and GQI examinations of 44 patients who underwent DBS surgery, were analyzed. To evaluate motor functions, the Unified Parkinson’s Disease Rating Scale (UPDRS) during on- and off-medication and Parkinson’s Disease Questionnaire-39 (PDQ-39) scales were used before and three months after DBS surgery. The study population was divided into two groups according to the improvement rate of scales: ≥ 50% and < 50%. Five target regions, reported to be affected in PD, were investigated. The parameters having statistically significant difference were subjected to a receiver operating characteristic (ROC) analysis. Results Quantitative anisotropy (qa) values from globus pallidus externus, globus pallidus internus (qa_Gpi), and substantia nigra exhibited significant distributional difference between groups in terms of the improvement rate of UPDRS-3 scale during on-medication (p = 0.003, p = 0.0003, and p = 0.0008, respectively). In ROC analysis, the best parameter in predicting DBS response included qa_Gpi with a cut-off value of 0.01370 achieved an area under the ROC curve, accuracy, sensitivity, and specificity of 0.810, 73%, 62.5%, and 85%, respectively. Optimal cut-off values of ≥ 0.01864 and ≤ 0.01162 yielded a sensitivity and specificity of 100%, respectively. Conclusion The imaging parameters acquired from GQI, particularly qa_Gpi, may have the ability to non-invasively predict the clinical outcome of DBS surgery.

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Section: Methodsmentioning

confidence: 99%