Predicting miRNA targets for hepatocellular carcinoma with an integrated method

Shi, Yonghong; Wen, Tianfu; Xiao, Deshuang; Dai, Lingbo; Song, Jun

doi:10.21037/tcr.2020.02.46

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…MicroRNA (miRNA), a small noncoding RNA molecule approximately 22 nucleotides in length, is estimated to regulate almost 60% of human protein-coding genes[ 6 ]. miRNA is closely associated with the pathogenesis of various types of tumors[ 7 ].…”

Section: Introductionmentioning

confidence: 99%

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

Zhang,

Chen,

Wei

et al. 2024

World J Clin Oncol

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BACKGROUND Emerging research suggests that microRNAs (miRNAs) play an important role in the development of hepatocellular carcinoma (HCC). A comprehensive analysis of recent research concerning miRNAs in HCC development could provide researchers with a valuable reference for further studies. AIM To make a comprehensive analysis of recent studies concerning miRNAs in HCC. METHODS All relevant publications were retrieved from the Web of Science Core Collection database. Bibliometrix software, VOSviewer software and CiteSpace software were used to visually analyze the distribution by time, countries, institutions, journals, and authors, as well as the keywords, burst keywords and thematic map. RESULTS A total of 9426 publications on this topic were found worldwide. According to the keywords analysis, we found that the studies of miRNAs focused on their expression level, effects, and mechanisms on the biological behaviour of HCC. Keywords bursting analysis showed that in the early years (2013–2017), “microRNA expression”, “gene expression”, “expression profile”, “functional polymorphism”, “circulating microRNA”, “susceptibility” and “mir 21” started to attract attention. In the latest phase (2018–2022), the hot topics turned to “sorafenib resistance”, “tumor microenvironment” and so on. CONCLUSION This study provides a comprehensive overview of the role of miRNAs in HCC development based on bibliometric analysis. The hotspots in this field focus on miRNAs expression level, effects, and mechanisms on the biological behavior of HCC. The frontiers turned to sorafenib resistance, tumor microenvironment and so on.

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Section: Introductionmentioning

confidence: 99%

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

Zhang,

Chen,

Wei

et al. 2024

World J Clin Oncol

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Filter and Wrapper Stacking Ensemble (FWSE): a robust approach for reliable biomarker discovery in high-dimensional omics data

Budhraja,

Doborjeh,

Singh

et al. 2023

Briefings in Bioinformatics

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Selecting informative features, such as accurate biomarkers for disease diagnosis, prognosis and response to treatment, is an essential task in the field of bioinformatics. Medical data often contain thousands of features and identifying potential biomarkers is challenging due to small number of samples in the data, method dependence and non-reproducibility. This paper proposes a novel ensemble feature selection method, named Filter and Wrapper Stacking Ensemble (FWSE), to identify reproducible biomarkers from high-dimensional omics data. In FWSE, filter feature selection methods are run on numerous subsets of the data to eliminate irrelevant features, and then wrapper feature selection methods are applied to rank the top features. The method was validated on four high-dimensional medical datasets related to mental illnesses and cancer. The results indicate that the features selected by FWSE are stable and statistically more significant than the ones obtained by existing methods while also demonstrating biological relevance. Furthermore, FWSE is a generic method, applicable to various high-dimensional datasets in the fields of machine intelligence and bioinformatics.

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Predicting miRNA targets for hepatocellular carcinoma with an integrated method

Cited by 2 publications

References 51 publications

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

Filter and Wrapper Stacking Ensemble (FWSE): a robust approach for reliable biomarker discovery in high-dimensional omics data

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