2023
DOI: 10.1101/2023.07.03.23292094
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Predicting non-response to ketamine for depression: a symptom-level analysis of real-world data

Abstract: Background Ketamine helps some patients with treatment resistant depression (TRD), but reliable methods for predicting which patients will, or will not, respond to treatment are lacking. Methods This is a retrospective analysis of PHQ-9 item response data from 120 military veterans with TRD who received repeated doses of intravenous racemic ketamine or intranasal eskatamine in a real-world clinic. Regression models were fit to individual patients' symptom trajectories and model parameters were analyzed to char… Show more

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