Predicting novel biomarkers for early diagnosis and dynamic severity monitoring of human ulcerative colitis
Yu Chen,
Li Chen,
Sheng Huang
et al.
Abstract:BackgroundUlcerative colitis is an emerging global health concern that poses a significant threat to human health and can progress to colorectal cancer if not diagnosed and treated promptly. Currently, the biomarkers used clinically for diagnosis and dynamic severity monitoring lack disease specificity.MethodsMouse models induced with 2%, 2.5%, and 3% DSS were utilized to simulate human UC with varying severities of inflammation. Transcriptome sequencing technology was employed to identify differentially expre… Show more
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