Predicting ongoing pregnancy chances after IVF and ICSI: a national prospective study

Lintsen, A.M.E.; Eijkemans, Marinus J.C.; Hunault, Claudine C.; Bouwmans, C.; Hakkaart, L.; Habbema, J. Dik F.; Braat, D.D.M.

doi:10.1093/humrep/dem183

Cited by 157 publications

(116 citation statements)

References 24 publications

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“…40 -44 In comparison, a recent national Dutch cohort of 4928 women undergoing ART had an average age of 33.6 years and a mean duration of attempting conception of 3.6 years, with a 1-year cumulative probability of ongoing pregnancy of 45%. 35 Importantly, the duration of time attempting conception in our study is greater than of all the studies with which we compare in the remaining discussion, and the mean age of the women in our study is also greater than most of them.…”

Section: Discussionmentioning

confidence: 61%

“…In a recent populationbased cohort of couples receiving ART in the Netherlands, the cumulative pregnancy rate at 1 year was 45%. 35 Taken together, these results suggest that the overall success rates of treatment with NPT might be comparable to ART despite greater per-cycle pregnancy rates with ART. Although it may seem paradoxical that a treatment with a lower per-cycle pregnancy rate than ART may have a comparable cumulative rates of pregnancy or live birth, very similar results have also been found in randomized trials of ART versus other less invasive therapies for couples with unexplained infertility.…”

Section: Discussionmentioning

confidence: 78%

“…For comparability with other reports of infertility outcomes, we assigned the time of this outcome as the time of conception leading to first live birth. 35 Secondarily, we also analyzed the cumulative proportion of first conceptions and cumulative proportion of withdrawals. Life-table analysis was used to adjust for couples withdrawing from treatment, or that completed 24 months of NPT treatment without pregnancy.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Outcomes From Treatment of Infertility With Natural Procreative Technology in an Irish General Practice

Stanford¹,

Parnell²,

Boyle³

2008

The Journal of the American Board of Family Medicine

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Objectives: We evaluated outcomes in couples treated for infertility with natural procreative technology (NaProTechnology, NPT), a systematic medical approach for optimizing physiologic conditions for conception in vivo, from an Irish general practice.Methods: All couples receiving treatment from 2 NPT-trained family physicians between February 1998 and January 2002 were studied. The main outcome was live birth, and secondary outcomes included conceptions and multiple births. Crude proportions and adjusted life-table proportions were calculated per 100 couples.Results: A total of 1239 couples had an initial consult for NPT, of which 1072 had been trying for at least a year to conceive and initiated treatment. The average female age was 35.8 years, the mean duration of attempting to conceive was 5.6 years, 24% had a prior birth, and 33% had previously attempted treatment with assisted reproductive technology (ART). All couples were taught to identify the fertile days of the menstrual cycle with the Creighton Model FertilityCare System, and most received additional medical treatment, including clomiphene (75%). In life-table analysis, the cumulative proportion of first live births for those completing up to 24 months of NPT treatment was 52.8 per 100 couples. The crude proportion was 25.5. Younger couples and couples without previous ART attempts had higher rates of live birth. Among live births, there were 4.6% twin births.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 78%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Outcomes From Treatment of Infertility With Natural Procreative Technology in an Irish General Practice

Stanford¹,

Parnell²,

Boyle³

2008

The Journal of the American Board of Family Medicine

View full text Add to dashboard Cite

show abstract

“…The patients' age, BMI and other known confounding factors such as duration of infertility, the serum levels of LH, FSH, TT and E 2 on the 3rd day of spontaneous menstrual cycle, the cycle length, the dosage of recombinant FSH administered, induction length, number of follicles, number of follicles with diameters of more than 14 mm, number of embryos transferred per cycle, embryo cleavage rate, good-quality embryo rate and fertilization rate have been well controlled in the present study. These factors have been shown important in large prospective studies 50,51 . The lifestyle factors such as smoking and alcohol intake were also well controlled in the study.…”

Section: Discussionmentioning

confidence: 99%

Auricular acupressure reduces anxiety levels and improves outcomes of in vitro fertilization: a prospective, randomized and controlled study

Xing

Huang

2013

Fertility and Sterility

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The study was to explore whether auricular acupressure (AA) can relieve anxiety during the period from trans-vaginal oocyte retrieval to the embryo transfer in IVF treatment and whether AA can improve the outcomes of IVF. 305 infertile patients with tubal blockage who were referred for IVF were included. The women were randomized into a control group with 102 cases, a Sham-AA group with 102 cases and an AA group with 101 cases. The anxiety levels were rated with Spielberger's State Trait Anxiety Inventory and the Amsterdam Preoperative Anxiety and Information Scale. Data of clinical pregnancy rate (CPR), implantation rate (IR) and live birth rate (LBR) were obtained. The levels of neuropeptide Y (NPY) and transforming growth factor alpha (TGF-alpha) in the follicular fluids were detected with ELISA. After treatment, in AA group, the levels of state anxiety, preoperative anxiety and need-for-information were significantly lower, whereas CPR, IR, LBR and NPY levels in the follicular fluids were markedly higher than Sham-AA group and control group. We concluded that AA could help to reduce anxiety levels associated with IVF and improves the outcomes of IVF partly through increasing the levels of NPY in the follicular fluids.

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“…The use of exogenous gonadotropins in combination with GnRH analogues for controlled ovarian hyperstimulation (COH) raises the number of oocytes retrieved and thus improves the results of IVF procedures [2], with cumulative pregnancy rate being approximately 63 % after 4 cycles [3,4]. However, the use of COH is associated with serious clinical problems like multiple pregnancies [5] and ovarian hyperstimulation syndrome (OHSS) [6].…”

Section: Introductionmentioning

confidence: 99%

Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles

Papler

Bokal

Tacer

et al. 2013

J Assist Reprod Genet

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Purpose The aim of our study was to determine whether there are any differences in the cumulus cell gene expression profile of mature oocytes derived from modified natural IVF and controlled ovarian hyperstimulation cycles and if these changes could help us understand why modified natural IVF has lower success rates. Methods Cumulus cells surrounding mature oocytes that developed to morulae or blastocysts on day 5 after oocyte retrieval were submitted to microarray analysis. The obtained data were then validated using quantitative real-time PCR. Results There were 66 differentially expressed genes between cumulus cells of modified natural IVF and controlled ovarian hyperstimulation cycles. Gene ontology analysis revealed the oxidation-reduction process, glutathione metabolic process, xenobiotic metabolic process and gene expression were significantly enriched biological processes in MNIVF cycles.Among differentially expressed genes we observed a large group of small nucleolar RNA's whose role in folliculogenesis has not yet been established. Conclusion The increased expression of genes involved in the oxidation-reduction process probably points to hypoxic conditions in modified natural IVF cycles. This finding opens up new perspectives for the establishment of the potential role that oxidation-reduction processes have in determining success rates of modified natural IVF.

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Predicting ongoing pregnancy chances after IVF and ICSI: a national prospective study

Abstract: The most important predictors of the pregnancy chance after IVF and ICSI are women's age and ICSI. The diagnostic category is of no consequence. Duration of subfertility and pregnancy history are of limited prognostic value.

Cited by 157 publications

References 24 publications

Outcomes From Treatment of Infertility With Natural Procreative Technology in an Irish General Practice

Outcomes From Treatment of Infertility With Natural Procreative Technology in an Irish General Practice

Auricular acupressure reduces anxiety levels and improves outcomes of in vitro fertilization: a prospective, randomized and controlled study

Differences in cumulus cells gene expression between modified natural and stimulated in vitro fertilization cycles

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