Predicting outcome for patients with node negative breast cancer: a comparative study of the value of flow cytometry and cell image analysis for determination of DNA ploidy

Vascular Invasion as an Independent Prognostic Factor in Lymph Node Negative Invasive Breast Cancer

“…Consistent with the results of a large number of studies, our study findings showed that nuclear grade played a prognostic role in node negative patients (Yuan et al, 1992;Gasparini et al, 1994;Carlmagno et al, 1996;Andrulis et al, 1998;Carol et al, 2002;Bekir et al, 2003;Polednak, 2003;Sebastian et al, 2004a;2004b;Gurleyik et al, 2007;Lee et al, 2009;Nimeus-Malmstrom et al, 2010;Song et al, 2011;Clayton et al, 2012). In the current study, the survival rate was obtained as 74.8% in grade three compared to 87.1% in grade one (Table 1), which is in contrast with the study by Ashwini et al (2008).…”

“…These findings are in line with the results of a large number of studies (Yuan et al, 1992;Gasparini et al, 1994;Carlmagno et al, 1996;Carol et al, 2002;Gurleyik et al, 2007;Florence et al, 2010), while in contrast with those of Androlis' study (Andrulis et al, 1998). Moreover, Herceptin protein had only a significant effect on survival in lymph node positive patients, which is in agreement with the results of the study by Flourence et al (2010).…”

“…It seems that estrogen receptor status has a predictive value in combination with adjuvant therapy; however, the effect of estrogen receptor status alone on the survival rate is questionable (Sebastian et al, 2004a;2004b). This finding is in contrast with those of a great number of studies (Yuan et al, 1992;Carol et al, 2002;Gurleyik et al, 2007;Florence et al, 2010).…”

“…On the contrary to the findings of many studies, no significant role was found for age in the 12-year survival rate in negative or positive lymph node patients (Yuan et al, 1992;Bekir, 2003;Polednak, 2003;Ashwini et al, 2008;Florence et al, 2010). This finding is consistent with the results of a few studies conducted on the issue (Gasparini et al, 1994;Carol et al, 2002;Polednak, 2003;Sebastian et al, 2004a;2004b;Nimeus-Malmstrom et al, 2010;Song et al, 2011).…”

Systemic Adjuvant Therapy of Node Negative Breast Cancer

“…Kontrol çalışmalı sonuçlar kapsayan son yayımlar (1,2,3,4,5,6,7) nodül negatif hastaların bazı alt gruplarının daha yüksek riske sahip olabileceklerine değinerek bu konuya yaklaşmaktadır. Bu göre, koltuk altı lenf nodüllerinin mikrometastazlı hastalığında, adjuvan keıno-ve hormonoterapi ile hastahğın doğal gidişinin değiştirilebileceği ortaya konulmuştur (2) Hepsi HSK için etkili görülmektedir (2,4,10).…”