2014
DOI: 10.1002/jps.24011
|View full text |Cite
|
Sign up to set email alerts
|

Predicting Passive and Active Tissue:Plasma Partition Coefficients: Interindividual and Interspecies Variability

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
57
0

Year Published

2016
2016
2023
2023

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 43 publications
(58 citation statements)
references
References 30 publications
1
57
0
Order By: Relevance
“…K t:pl values in tissues of rat were calculated according to the method previously described (Ruark et al, 2014). A high K t:pl was obtained in adipose tissue, indicating that DPT possessed high affinity to adipose tissue.…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…K t:pl values in tissues of rat were calculated according to the method previously described (Ruark et al, 2014). A high K t:pl was obtained in adipose tissue, indicating that DPT possessed high affinity to adipose tissue.…”
Section: Resultsmentioning
confidence: 99%
“…Several in silico methods to estimate K t:pl have been reported (Poulin and Theil, 2002; Berezhkovskiy, 2004; Rodgers and Rowland, 2006; Schmitt, 2008; Peyret et al, 2010; Ruark et al, 2014). In the present study, K t:pl values in rat were calculated using the approach developed recently by Ruark et al (2014), which was considered to provide a more comprehensive tissue composition model than previous approaches.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…The tissue data needed for calculating partition coefficients in human and rat, taken from Ruark et al (2014), include: cellular and water fractions of total volume, lipid and protein fractions of cellular volume, lipid fractions of the total lipid volume, the pH of each tissue, and the fractional volume of protein in plasma. A default plasma pH of 7.4 is taken from Schmitt (2008b) in calculating ionization.…”
Section: Methodsmentioning
confidence: 99%