Predicting Proliferative Retinopathy in a Brazilian Population of Preterm Infants With the Screening Algorithm WINROP

Hård, Anna‐Lena; Löfqvist, Chatarina; Filho, João Borges Fortes; Procianoy, Renato S.; Smith, Lois E H; Hellström, Ann

doi:10.1001/archophthalmol.2010.255

Cited by 84 publications

(66 citation statements)

References 23 publications

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“…This could explain the higher ROP incidence rate found. 15 The Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) study showed an incidence of 65.8%. 16 However, the weight criterion required for inclusion in the study was lower than that of the present study (weight < 1,250 grams).…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for retinopathy of prematurity in a Brazilian reference service

et al. 2014

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CONTEXT AND OBJECTIVE: Retinopathy of prematurity (ROP) is a known cause of blindness in which diagnosis and timely treatment can prevent serious harm to the child. This study aimed to evaluate the incidence of ROP and its association with known risk factors. DESIGN AND SETTING: Longitudinal incidence study in the neonatal intensive care unit (NICU) of Universidade Estadual de Montes Claros. METHODS: Newborns admitted to the NICU with gestational age less than 32 weeks and/or birth weight less than 1,500 grams, were followed up over a two-year period. The assessment and diagnosis of ROP were defined in accordance with a national protocol. The chi-square test or Fisher's exact test were used to determine associations between independent variables and ROP. Analysis on the independent effect of the variables on the results was performed using multiple logistic regression. RESULTS: The incidence of ROP was 44.5% (95% confidence interval, CI = 35.6-46.1) in the study population. The risk factors associated with the risk of developing the disease were: birth weight less than 1,000 grams (odds ratio, OR = 4.14; 95% CI = 1.34-12.77); gestational age less than 30 weeks (OR = 6.69; 95% CI = 2.10-21.31); use of blood derivatives (OR = 4.14; 95% CI = 2.99-8.99); and presence of sepsis (OR = 1.99; 95% CI = 1.45-2.40). CONCLUSIONS: The incidence of ROP was higher than that found in the literature. The main risk factors were related to extreme prematurity. RESUMO CONTEXTO E OBJETIVO:A retinopatia da prematuridade (ROP) é causa conhecida de cegueira e diagnóstico e tratamento oportunos podem evitar graves danos à criança. Este estudo objetivou avaliar a incidência da ROP e sua associação com fatores de risco conhecidos.

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Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for retinopathy of prematurity in a Brazilian reference service

et al. 2014

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“…Recently, clinical prediction models to early identify patients in risk of ROP were presented. WINROP [29][30][31] and PINT-ROP 32 were presented using postnatal longitudinal weight gain measurements. ROPScore, by the other hand, uses the BW and the weight measured at completed 6 weeks of life as weighted values in the final calculation of the score.…”

Section: Discussionmentioning

confidence: 99%

A predictive score for retinopathy of prematurity in very low birth weight preterm infants

Eckert

Filho

Maia

et al. 2011

Eye

107

102

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Aims This study describes the development of a score based on cumulative risk factors for the prediction of severe retinopathy of prematurity (ROP) comparing the performance of the score against the birth weight (BW) and gestational age (GA) in order to predict the onset of ROP. Methods A prospective cohort of preterm infants with BWp1500 g and/or GAp32 weeks was studied. The score was developed based on BW, GA, proportional weight gain from birth to the 6th week of life, use of oxygen in mechanical ventilation, and need for blood transfusions from birth to the 6th week of life. The score was established after linear regression, considering the impact of each variable on the occurrences of any stage and severe ROP. Receiver operating characteristic (ROC) curves were used to determine the best sensitivity and specificity values for the score. All variables were entered into an Excel spreadsheet (Microsoft) for practical use by ophthalmologists during screening sessions. Results The sample included 474 patients. The area under the ROC curve for the score was 0.77 and 0.88 to predict any stage and severe ROP, respectively. These values were significantly higher for the score than for BW (0.71) and GA (0.69) when measured separately. Conclusions ROPScore is an excellent index of neonatal risk factors for ROP, which is easy to record and more accurate than BW and GA to predict any stage ROP or severe ROP in preterm infants. The scoring system is simple enough to be routinely used by ophthalmologists during screening examination for detection of ROP.

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“…So far, our results are in accordance with the results from Sweden and USA reporting 100% sensitivity (and therefore, by induction, 100% negative predictive values) (ref. 26,32,33,[38][39] ) while studies from China, Mexico, Brazil or Korea [34][35][36][37] reported sensitivity values ranging from 85% to 95%. The WinROP system correctly identified all 24 infants requiring or potentially requiring treatment (Type 1 or Type 2).…”

Section: Discussionmentioning

confidence: 99%

“…Based on the results of weekly weight increments in Swedish infants, an online system WinROP was created aiming at timely prediction of a high risk of serious ROP development 25,32,33 . Several studies that evaluated ROP in different populations have been published with varying results 23,25,26,[32][33][34][35][36][37][38][39] . In this paper, we would like to contribute to this discussion by presenting an evaluation of the WinROP system based on data acquired at our department.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the WinROP system for identifying retinopathy of prematurity in Czech preterm infants

Timkovič¹,

Pokrývková²,

Janurová³

et al. 2017

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims. Retinopathy of Prematurity (ROP) is a potentially serious condition that can afflict preterm infants. Timely and correct identification of individuals at risk of developing a serious form of ROP is therefore of paramount importance. WinROP is an online system for predicting ROP based on birth weight and weight increments. However, the results vary significantly for various populations. It has not been evaluated in the Czech population. This study evaluates the test characteristics (specificity, sensitivity, positive and negative predictive values) of the WinROP system in Czech preterm infants. Methods. Data on 445 prematurely born infants included in the ROP screening program at the University Hospital Ostrava, Czech Republic, were retrospectively entered into the WinROP system and the outcomes of the WinROP and regular screening were compared. Results. All 24 infants who developed high-risk (Type 1 or Type 2) ROP were correctly identified by the system. The sensitivity and negative predictive values for this group were 100%. However, the specificity and positive predictive values were substantially lower, resulting in a large number of false positives. Extending the analysis to low risk ROP, the system did not provide such reliable results. Conclusions. The system is a valuable tool for identifying infants who are not likely to develop high-risk ROP and this could help to substantially reduce the number of preterm infants in need of regular ROP screening. It is not suitable for predicting the development of less serious forms of ROP which is however in accordance with the declared aims of the WinROP system.

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Predicting Proliferative Retinopathy in a Brazilian Population of Preterm Infants With the Screening Algorithm WINROP

Cited by 84 publications

References 23 publications

Incidence and risk factors for retinopathy of prematurity in a Brazilian reference service

Incidence and risk factors for retinopathy of prematurity in a Brazilian reference service

A predictive score for retinopathy of prematurity in very low birth weight preterm infants

Evaluation of the WinROP system for identifying retinopathy of prematurity in Czech preterm infants

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