Predicting quality of life in AMD patients—insights on the new NICE classification and on a bolt-on vision dimension for the EQ-5D

Peixoto, Ricardo De Sousa; Krstic, Lazar; Hill, Sophie C L; Foss, Alexander

doi:10.1038/s41433-021-01414-3

Cited by 12 publications

(6 citation statements)

References 16 publications

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“…Degenerative retinal diseases are reported as heterogeneous and multiple etiological groups of disorders that hamper the vision of human beings, resulting in compromised quality of life [ 6 ]. Retinitis pigmentosa (RP) [ 7 ], age-related macular degeneration (AMD) [ 8 ], diabetic retinopathy (DR) [ 9 ], Stargardt macular dystrophy (STGD) [ 10 ], and Leber congenital amaurosis (LCA) [ 11 ] are some examples of degenerative retinal diseases. Although the etiology of the mentioned diseases varies, the hallmark characteristic feature of these degenerative retinal diseases is the progressive death of highly differentiated cells within the neurosensory retina, called the retinal pigment epithelium (RPE), or in the photoreceptor cells in the human eye [ 2 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Inflammation in Retinal Neurodegeneration and Degenerative Diseases

Kaur

Singh

2021

IJMS

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Retinal neurodegeneration is predominantly reported as the apoptosis or impaired function of the photoreceptors. Retinal degeneration is a major causative factor of irreversible vision loss leading to blindness. In recent years, retinal degenerative diseases have been investigated and many genes and genetic defects have been elucidated by many of the causative factors. An enormous amount of research has been performed to determine the pathogenesis of retinal degenerative conditions and to formulate the treatment modalities that are the critical requirements in this current scenario. Encouraging results have been obtained using gene therapy. We provide a narrative review of the various studies performed to date on the role of inflammation in human retinal degenerative diseases such as age-related macular degeneration, inherited retinal dystrophies, retinitis pigmentosa, Stargardt macular dystrophy, and Leber congenital amaurosis. In addition, we have highlighted the pivotal role of various inflammatory mechanisms in the progress of retinal degeneration. This review also offers an assessment of various therapeutic approaches, including gene-therapies and stem-cell-based therapies, for degenerative retinal diseases.

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Section: Introductionmentioning

confidence: 99%

The Role of Inflammation in Retinal Neurodegeneration and Degenerative Diseases

Kaur

Singh

2021

IJMS

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“…Additionally, managing the neovascular form of AMD is further increasing the costs in the healthcare system (Kim et al, 2019). The progressive degenerative disease of the eye has no cure and is often diagnosed late, thereby diminishing the quality of life by restricting patients' ability to read, drive, perform daily tasks, and recognize faces (De Sousa Peixoto et al, 2021). Compared with patients suffering from glaucoma and diabetic retinopathy, studies show that the general psychological state is most impaired in people with AMD (Gusar et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Spiritual and religious perspectives in persons with visual impairment due to age-related macular degeneration

Salzer

Samoila²,

Moshkenani

et al. 2023

Front. Psychol.

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IntroductionAge-related macular degeneration (AMD) is one of the global leading causes of severe vision loss. Patients suffering from AMD face complex spiritual and mental challenges that have an impact on the course of their disease, their quality of life, and their relationship with their surroundings.MethodsA survey was carried out using a 21-item questionnaire between August 2020 and June 2021 among 117 patients from different countries to investigate how spirituality, religion, and their way of practicing them affected the experiences and daily lives of patients suffering from AMD, and whether it helped them cope with the disease.ResultsOur study concluded that spirituality and religion are important factors that facilitate patients’ ability to cope with a progressive degenerative disease such as AMD. Patients who are religious are more at peace with having AMD. Practices that contribute to patients being at peace in accepting the disease are regular prayers or meditation. Spirituality and religion are important components that promote a healthier and happier emotional state and mental wellbeing. In particular, by believing that death is not the end, patients feel more hopeful, which helps in their adjustment to a seemingly hopeless health condition. A significant number of AMD patients desire to talk about God with the medical staff. The profile of such patients could be those believing in a higher power, praying often, participating in religious services, being worried about the loss of vision, and needing assistance in daily life.DiscussionAn interdisciplinary and multidimensional team of medical health professionals including mental health workers and chaplains can be of great value in managing persons with AMD.

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“…Degenerative retinal diseases are defined by heterogeneous and multiple etiological groups of disorders, which jeopardize the vision of human beings, especially the elderly, leading to a decline in quality of life (Prem Senthil et al, 2017). There are some typical examples of degenerative retinal diseases, such as retinitis pigmentosa (RP) (Chaumet‐Riffaud et al, 2017), age‐related macular degeneration (AMD) (De Sousa Peixoto et al, 2021), diabetic retinopathy (DR) (Pereira et al, 2017), and glaucoma. Interestingly, visual disturbances involving abnormalities in visual acuity, color perception, contrast sensitivity, and visual field are also observed in Alzheimer's disease (AD), Parkinson's disease (PD) as well as in other neurodegenerative diseases (Ramirez et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Brain‐derived neurotrophic factor in degenerative retinal diseases: Update and novel perspective

Zhang

2023

J of Neuroscience Research

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Dysfunction and death of neuronal cells are cardinal features of degenerative retinal diseases that are known to arise as the disease progresses. Increasingly evidence suggests that abnormal expression of brain‐derived neurotrophic factor (BDNF) may serve as an obligatory relay of the dysfunction and death of neuronal cells in degenerative retinal diseases. Although disorder of BDNF, whether depletion or augmentation, has been connected with neuronal apoptosis and neuroinflammation, the exact mechanisms underlying the effect of impaired BDNF expression on degenerative retinal diseases remain unclear. Here, we present an overview of how BDNF is linked to pathological mechanism of retinal degenerative diseases, summarize BDNF‐based treatment strategies, and discuss possible research perspectives in the future.

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Predicting quality of life in AMD patients—insights on the new NICE classification and on a bolt-on vision dimension for the EQ-5D

Cited by 12 publications

References 16 publications

The Role of Inflammation in Retinal Neurodegeneration and Degenerative Diseases

The Role of Inflammation in Retinal Neurodegeneration and Degenerative Diseases

Spiritual and religious perspectives in persons with visual impairment due to age-related macular degeneration

Brain‐derived neurotrophic factor in degenerative retinal diseases: Update and novel perspective

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