Predicting resistant etiology in hospitalized patients with blood cultures positive for Gram-negative bacilli

Falcone, Marco; Tiseo, Giusy; Dentali, Francesco; Regina, Micaela La; Foglia, Emanuela; Gambacorta, Maurizia; Garagiola, Elisabetta; Bonardi, Giorgio; Clerici, Pierangelo; Colombo, Fabrizio; Farcomeni, Alessio; Concia, Ercole; Corrao, Salvatore; Campanini, Mauro; Mazzone, Antonino

doi:10.1016/j.ejim.2018.01.029

Cited by 28 publications

(19 citation statements)

References 26 publications

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“…Clinical data were assessed and recorded at the onset of signs of sepsis or septic shock. Data about the use of inotropes, the source of infection, and the administered antimicrobial therapy has been also recorded [15]. Study investigators prospectively followed all included patients with bedside visits every day.…”

Section: Methodsmentioning

confidence: 99%

Interplay between Nox2 Activity and Platelet Activation in Patients with Sepsis and Septic Shock: A Prospective Study

Tiseo

Forniti

Nocella

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Although preclinical studies highlighted the potential role of NADPH oxidase (NOX) in sepsis, only few studies evaluated the oxidative stress in patients with sepsis and septic shock. The objective of the study is to appraise the oxidative stress status and platelet function in patients with sepsis and septic shock compared to healthy controls. Methods and Results. Patients with sepsis or septic shock admitted to the hospital Policlinico Umberto I (Sapienza University, Rome) underwent a blood sample collection within 1 hour from admission. Platelet aggregation, serum thromboxane B2 (TxB2), soluble NOX2-derived peptides (sNox2-dp), and hydrogen peroxide breakdown activity (HBA) were measured and compared to those of healthy volunteers. Overall, 33 patients were enrolled; of these, 20 (60.6%) had sepsis and 13 (39.4%) septic shock. Compared to healthy controls ( n = 10 , age 67.8 ± 3.2 , male 50%), patients with sepsis and septic shock had higher platelet aggregation (49% (IQR 45-55), 60% (55.75-67.25), and 73% (IQR 69-80), respectively, p < 0.001 ), higher serum TxB2 (77.5 (56.5-86.25), 122.5 (114-131.5), and 210 (195-230) pmol/L, respectively, p < 0.001 ), higher sNox2-dp (10 (7.75-12), 19.5 (17.25-21), and 33 (29.5-39) pg/mL, respectively, p < 0.001 ), and lower HBA (75% (67.25-81.5), 50% (45-54.75), and 27% (21.5-32.5), respectively, p < 0.001 ). Although not statistically significant, a trend in higher levels of serum TxB2 and sNox2-dp in patients who died was observed. Conclusions. Patients with septic shock exhibit higher Nox2 activity and platelet activation than patients with sepsis. These insights joined to better knowledge of these mechanisms could guide the identification of future prognostic biomarkers and new therapeutic strategies in the scenario of septic shock.

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Section: Methodsmentioning

confidence: 99%

Interplay between Nox2 Activity and Platelet Activation in Patients with Sepsis and Septic Shock: A Prospective Study

Tiseo

Forniti

Nocella

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Table 1 summarizes all aspects responsible for the great heterogeneity among European LTCFs. The different typology of LTCFs [6], the regulatory processes [7], the quality monitoring [8], the local epidemiology of MDRO [9][10][11][12][13], the variability of infection control [14,15] and antimicrobial stewardship (AS) programs [3] account for the high heterogeneity among LTCFs in Europe.…”

Section: Heterogeneity Of Nursing Homes In Europementioning

confidence: 99%

Prevention of the spread of multidrug-resistant organisms in nursing homes

2021

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The increase in the aged population led to a global rise in the demand for elderly healthcare services, such as long-term care facilities (LTCFs), nursing homes, residential homes. Unfortunately, the spread of multidrug-resistant organisms (MDROs) in these structures represent an urgent public health threat requiring immediate action. The aim of this review is to provide a practice guide for the prevention of infections in European LTCFs. A team of experts identify specific problems and proposed practical solutions for the management of colonized and infected patients residing in LTCFs. The heterogeneity of LTCF represents one of the main problems for the implementation of standardized surveillance and infection control programs. Crucial steps involved in the spread of infections among LTCF residents are represented by patient's accommodation, MDRO screening on admission, management of patients with rectal colonization by MDROs, management of patients at high risk of MDRO infections, MDRO transmission by staff and implementation of antimicrobial stewardship. Efforts to implement specific actions in each of these fields are required to reduce the infections in this setting.

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“…Carbapenem-resistant Enterobacterales (CRE) represent a threat for public health, being among the top multidrug-resistant pathogens on WHO's priority list [1][2][3][4]. Intestinal colonization by CRE is a risk factor for developing subsequent infection [5][6].…”

Section: Introductionmentioning

confidence: 99%

Bloodstream infections in patients with rectal colonization by Klebsiella pneumoniae producing different type of carbapenemases: a prospective, cohort study (CHIMERA study)

Falcone¹,

Tiseo²,

Galfo³

et al. 2022

Clinical Microbiology and Infection

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Predicting resistant etiology in hospitalized patients with blood cultures positive for Gram-negative bacilli

Cited by 28 publications

References 26 publications

Interplay between Nox2 Activity and Platelet Activation in Patients with Sepsis and Septic Shock: A Prospective Study

Interplay between Nox2 Activity and Platelet Activation in Patients with Sepsis and Septic Shock: A Prospective Study

Prevention of the spread of multidrug-resistant organisms in nursing homes

Bloodstream infections in patients with rectal colonization by Klebsiella pneumoniae producing different type of carbapenemases: a prospective, cohort study (CHIMERA study)

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