Predicting retinal pigment epithelium remodelling and its functional impact

Vilares-Morgado, Rodrigo; Madeira, Carolina; Falcão, Manuel; Godinho, Gonçalo; Ribeiro, Ana Margarida Martins; Beato, João; Pedrosa, Ana Catarina; Brandão, Elisete; Falcão‐Reis, Fernando; Carneiro, Ângela

doi:10.1007/s00417-021-05129-9

Cited by 3 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5,6 Additionally, the remodeling of the RPE may not be correlated with better long-term visual outcomes. 7 However, in our study, although the grade of the patient's RPE tear was grade 4, the RPE layer still recovered completely (Figure 4). In addition, VA in the patient's left eye was restored to 20/20, and there was no significant difference in the mfERG results between the two eyes.…”

Section: Discussioncontrasting

confidence: 47%

Complete recovery of the retinal pigment epithelium layer after spontaneous large serous retinal pigment epithelial tear

Zhu

Xiao

Luo

et al. 2022

European Journal of Ophthalmology

View full text Add to dashboard Cite

Introduction The objective of this study is to report a case of complete recovery of the retinal pigment epithelium (RPE) layer after spontaneous large serous RPE tear and explore the possible RPE repair mechanism. Case description A 63-year-old male patient developed serous detachment of the RPE in the macula of his left eye. During the follow-up period, an oval-shaped RPE tear spontaneously occurred in the macular area, and fundus autofluorescence showed that the torn area was 6.59 mm2. Spectral-domain optical coherence tomography (OCT) revealed that the subretinal fluid had been absorbed and that the continuity of the RPE layer was gradually restored from the periphery to the center over the course of 9 months. Moreover, visual acuity (VA) in the left eye was restored to 20/20, and there was no significant difference in macular function between the two eyes, as measured by multifocal electroretinography, at the last follow-up. In addition, the patient received no special treatment during the entire follow-up period. Conclusion The integrity of the RPE layer can be restored completely after extensive RPE tear, and recovered RPE may allow the recovery of macular function.

show abstract

Section: Discussioncontrasting

confidence: 47%

Complete recovery of the retinal pigment epithelium layer after spontaneous large serous retinal pigment epithelial tear

Zhu

Xiao

Luo

et al. 2022

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Caramoy et al 18 first observed RPE tear repair tissue in a small RPE tear, suggesting that smaller RPE tears were more prone to develop TARP. Recently, Vilares-Morgado et al 16 found that repaired RPE tears were associated with younger age, presence of subretinal fluid at the time of RPE tear, and smaller preexisting PED. These associations were not confirmed in our cohort.…”

Section: Discussionmentioning

confidence: 99%

“…A female prevalence among patients with RPE tears has been observed in our and previous studies, with female patients representing 60% to 70% of the different cohorts. 9,13,16,18 Recent large-cohort database studies based on OCT measurements found mild gender differences in the RPE-BM complex thickness between male and female patients, with men having a thicker RPE-BM complex than women. 24 This may, at least in part, explain why the RPE is more prone to tear in women than in men.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Associations and Prognostic Implications of Repair Tissue Proliferation in Eyes With Retinal Pigment Epithelium Tears

Cicinelli

Rabiolo

Montesano

et al. 2022

Retina

View full text Add to dashboard Cite

Purpose: To investigate demographic and clinical factors influencing the longitudinal changes of retinal pigment epithelium (RPE) dehiscence area after RPE tears, including the presence of RPE tear-associated repair proliferation (TARP), and identify factors associated with TARP development over follow-up.Methods: Retrospective, single-center, observational cohort study of patients with a history of macular neovascularization and RPE tear. The area of RPE dehiscence was measured on repeated short-wavelength fundus autofluorescence imaging. Associations between covariates and RPE dehiscence areas were tested with multivariable linear mixed models. Associations between TARP development and clinical variables were investigated with Cox regression models. Factors associated with visual acuity changing rates were explored with linear mixed models.Results: Thirty-seven eyes of 36 patients were included in this study and followed for a median time of 18 months. Tear-associated repair proliferation was identified in 27 eyes (73%). The median time for TARP detection was 112 days; none of the investigated factors was significantly associated with TARP occurrence. The presence of TARP (estimate: 20.042 mm 2 /month; P = 0.001) and female gender (estimate: 20.035 mm 2 /month; P = 0.006) were associated with slower rates of RPE dehiscence enlargement over time. Faster rates of visual improvement were observed in eyes with TARP compared with those without TARP (estimate = 20.010 logarithm of the minimum angle of resolution/month if TARP was present; P = 0.008).Conclusion: Retinal pigment epithelium tear repair with TARP and female gender were associated with slower RPE degeneration after RPE tears. The presence of TARP was associated better visual prognosis. Additional research on factors promoting TARP development may have therapeutic and prognostic implications.

show abstract

“…1 In addition, correlations between multimodal imaging of healing RPE tears and functional outcomes remain controversial. 2,3 We report the morphofunctional correlation of the resurfacing tissue secondary to a RPE tear in nAMD, including high-resolution optical coherence tomography (High-Res OCT, SPECTRALIS, Heidelberg Engineering, Heidelberg, Germany) and microperimetry.…”

mentioning

confidence: 99%

Multimodal Imaging and Microperimetry of Retinal Pigment Epithelium Tear-Associated Resurfacing Tissue

Ramtohul

Cabral

Freund

2023

Retina

View full text Add to dashboard Cite

Predicting retinal pigment epithelium remodelling and its functional impact

Cited by 3 publications

References 26 publications

Complete recovery of the retinal pigment epithelium layer after spontaneous large serous retinal pigment epithelial tear

Complete recovery of the retinal pigment epithelium layer after spontaneous large serous retinal pigment epithelial tear

Clinical Associations and Prognostic Implications of Repair Tissue Proliferation in Eyes With Retinal Pigment Epithelium Tears

Multimodal Imaging and Microperimetry of Retinal Pigment Epithelium Tear-Associated Resurfacing Tissue

Contact Info

Product

Resources

About