Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors

Wen, H. Joseph; Chen, Pau‐Chung; Chiang, Tung Liang; Lin, Shio‐Jean; Chuang, Yi-Li; Guo, Yang

doi:10.1111/j.1365-2133.2009.09412.x

Cited by 82 publications

(87 citation statements)

References 38 publications

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“…This is consistent with our findings of the significant associations between newly renovated homes during the prenatal period and childhood AD. A recent study found that there were significant higher concentrations of IL-4 and IL-5 in cord blood of neonates who had been exposed to renovation materials (e.g., floor covering) and new furniture [17]. VOCs are transferred from the placenta to the fetus and can affect the neonatal immune system by elevating IL-production and reducing the production of interferon [18,19].…”

Section: Discussionmentioning

confidence: 99%

Residential Risk Factors for Atopic Dermatitis in 3- to 6-Year Old Children: A Cross-Sectional Study in Shanghai, China

Yan

Zheng

et al. 2016

IJERPH

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Background: Atopic dermatitis (AD) is common among pre-school children in Shanghai. This study aimed to identify the risk factors for childhood AD from the perspectives of home environment, demographics and parents-grandparents’ atopic disease. Methods: A cross-sectional study was conducted in Shanghai in April–June, 2010. Preschool children’s parents or guardians were invited to participate a questionnaire survey in six districts (two urban and four suburban/rural) and 6624 children were finally recruited (51.3% boys). AD diagnosis was based on the U.K. Working Party’s (UKWP) criteria. Adjusted odds ratios (AOR) with 95% confidence intervals (95% CI) were calculated by multiple logistic regression. Results: A total of 8.5% of children ever had AD. Around 10.2% of the mothers had lived in newly renovated/decorated homes (NRDH) during the prenatal period (one year before or during pregnancy) and 9.5% got new home furniture (NHF) during the same period. AD was more common in children when mothers had lived in NRDH homes during the prenatal period (AOR = 1.41; 95% CI 1.03–1.93), the current home had indoor mold (2.00, 1.48–2.70), parents-grandparents’ had atopic diseases (3.85, 3.05–4.87), the children had food allergy (3.40, 2.63–4.40) or children lived in urban area (1.52, 1.18–1.96). Associations between AD and NRDH, NHF and indoor molds were only significant in children without parents-grandparents’ atopic diseases. There was an interaction effect between parents-grandparents’ atopic diseases and NRDH (p < 0.05). Conclusions: Home renovation/ redecoration, new furniture and indoor mold, urban residency, heredity disposition and food allergy can be risk factors for childhood AD in Shanghai.

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Section: Discussionmentioning

confidence: 99%

Residential Risk Factors for Atopic Dermatitis in 3- to 6-Year Old Children: A Cross-Sectional Study in Shanghai, China

Yan

Zheng

et al. 2016

IJERPH

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“…In the past decades, several studies have investigated the risk factors for early development of atopy or allergic symptoms in young children [2][3][4] . Various mechanisms, such as viral infection, cytokine dysregulation, genetic variation and im-mune dysfunction, have been identified as possible explanations for the development of allergic diseases in early life [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Cord Blood Soluble CD14 Predicts Wheeze and Prolonged Cough in Young Children: The PATCH Study

Tu²,

Chiu³

et al. 2016

Int Arch Allergy Immunol

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cord blood sCD14, older maternal age and more siblings. In the multivariate logistic regression analysis, cord blood sCD14 was the only independent predictive biomarker for wheeze and prolonged cough by 1 year of age. Every 100-ng/ml increase in cord blood sCD14 resulted in a 1.56-fold higher risk of developing wheeze and a 1.62-fold higher risk of prolonged cough in children by 1 year of age. Conclusions: Cord blood sCD14 may be a useful biomarker for predicting infant wheeze and prolonged cough by 1 year of age.

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“…Two were excluded because they considered only household conditions (peeling paint/plaster/ wallpaper) [13,14]; one because the focus was on a Chemical Odor Intolerance Index including paint and respiratory problems [15]; and six because their focus was on inflammatory markers [16], pneumonia [17], acute dermatitis [18], eczema and unspecified allergic symptoms [16], or sick building syndrome symptoms among which unspecific airways symptoms [19,20].…”

Section: Epidemiological Studiesmentioning

confidence: 99%

Systematic review of the effects of domestic paints on asthma related symptoms in people with or without asthma

et al. 2013

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Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors

Abstract: This investigation provides a technique for predicting the risk of infantile AD based on hereditary and environmental factors, which could be used for developing a preventive strategy against AD, especially among those children with a family history of atopy.

Cited by 82 publications

References 38 publications

Residential Risk Factors for Atopic Dermatitis in 3- to 6-Year Old Children: A Cross-Sectional Study in Shanghai, China

Residential Risk Factors for Atopic Dermatitis in 3- to 6-Year Old Children: A Cross-Sectional Study in Shanghai, China

Cord Blood Soluble CD14 Predicts Wheeze and Prolonged Cough in Young Children: The PATCH Study

Systematic review of the effects of domestic paints on asthma related symptoms in people with or without asthma

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