Landouzy-Sepsis (Sepsis tuberculosa acutissima) is a rare presentation of disseminated tuberculosis as shock and multi-organ failure. The condition if not treated promptly causes rapid death in an immunocompromised patient. We report one such case with refractory shock, ARDS, renal failure and liver dysfunction treated with peri-arrest VA-ECMO at our centre. The use of VA-ECMO have been explained in several scenarios for maintaining oxygenation and perfusion in cases of irreversible cardio-respiratory failure. In a developing country like ours, cost of initiating ECMO support has to be contemplated. We were successful in convincing the family to consent for the procedure and we initiated VA-ECMO on this patient after proper counseling of the family regarding possible outcome.