Predicting the Probability of Meningioma Recurrence in the Preoperative and Early Postoperative Period: A Multivariate Analysis in the Midterm Follow-Up

Abstract

We reviewed the clinical, radiological, surgical, and histopathological features of patients with meningiomas to identify factors that can predict tumor recurrence after ''microscopic total removal,'' to improve preoperative surgical planning, and to help determine the need for close radiological observation at shorter intervals or the need for radiotherapy as an adjuvant treatment in the early postoperative period. Clinical data, magnetic resonance imaging studies, angiographic data, operative reports, and histopathological findings were examined retrospectively in 137 patients with a meningioma treated microsurgically and with no evidence of residual tumor on postoperative MR images. Based on univariate analysis, tumor size, a mushroom shape, proximity to major sinuses, edema, osteolysis, cortical penetration, signal intensity on T2-weighted MRIs, pial-cortical arterial supply, presence of a brain-tumor interface in surgery, Simpson's criteria, and histopathological classification were significant predictors for recurrence. However, age, gender, location of tumor, dural tail, calcification, signal intensity on T1-weighted images, and histopathologic subtypes in the benign group were not significant predictors. By Cox regression analysis the most important variables related to the time to recurrence were mushroom shape, osteolysis, dural tail, and proximity to major sinuses. Aggressive surgical therapy with wider dural removal should be considered in the presence of the preoperative predictors of a recurrence. Close radiological observation at shorter intervals or radiotherapy should be considered as adjuvant therapy in high-risk patients

Spinal meningiomas: clinicoradiological factors predicting recurrence and functional outcome

“…14,18 The recurrence rate has also been described as higher for males when all histopathological grades of intracranial meningiomas were considered. 13 However, similar observation for spinal meningiomas is not available in the literature, presumably due to fewer reported recurrences. A dural tail can be present in up to half of the cases of spinal meningiomas.…”

A multivariate analysis of prognostic factors for health-related quality of life in patients with surgically managed meningioma

“…5,6 Several groups have investigated the prognostic significance of baseline HQOL parameters and baseline clinical characteristics for clinical outcome. [7][8][9][10] In these studies, a variety of unspecialized HQOL instruments were used to evaluate global HQOL after meningioma resection. However, it is not sufficient to describe the relationship between meningioma and HQOL in global terms.…”

Correlation of p63 protein expression and Ki-67 labelling index with histological grades of meningiomas: A five years study

“…Ilidian et al, 9 reported that age and gender has no influence on proliferative activity. Kasuya et al 10 reported that male gender was an independent risk factor for high proliferative potential.…”