Prediction of additional lymph node positivity and clinical outcome of micrometastases in sentinel lymph nodes in cutaneous melanoma: A multi‐institutional study of 450 patients in Japan

Namikawa, Kenjiro; Yamazaki, Naoya; Nakai, Yasuo; Ihn, Hironobu; Tomita, Yasushi; Uhara, Hisashi; Takenouchi, Tatsuya; Kiyohara, Yoshio; Moroi, Yoichi; Yamamoto, Yuhei; Otsuka, Fujio; Kawanishi, Hideki; Iizuka, Hajime; Hatta, Naohito; Kadono, Takafumi

doi:10.1111/j.1346-8138.2011.01318.x

Cited by 23 publications

(20 citation statements)

References 35 publications

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“…Although being older than 65 years was found to be an independent prognostic factor of OS, gender and tumor localization were not associated with OS and disease-free survival (DFS) (Wu et al, 2013). However, another study reported that tumor location, gender and age were not correlated with DFS and OS (Namikawa et al, 2012). In another study from Japan, age and gender were not associated with DFS for patients with thick melanoma (Fujisawa et al, 2012).…”

Section: Discussionmentioning

confidence: 86%

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

Gamsızkan¹,

Yılmaz²,

Büyükbabanı³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6%) cases were male, 730 (46.4%) cases were female. One thousand four hundred forty-seven (92%) cases were invasive melanoma and 127 (8%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9%). It was followed by nodular melanoma in 379 (26.2%), acral lentiginous melanoma (ALM) in 191 (13.2%) and lentigo maligna melanoma in 132 (9.1%), respectively. On univariate analysis, lymphovascular invasion (p<0.001), tumor thickness (p<0.001), histopathological subtype (p<0.001), Clark level (p=0.001), ulceration (p<0.001), ≥6/mm 2 mitosis (p=0.005), satellite formation (p=0.001) and gender (p=0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p=0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index; most of the melanoma lesions' thickness were greater than 2 mm, corresponding Clark IV. Vascular invasion and tumor thickness are the most important factors for sentinel lymph node involvement.

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Section: Discussionmentioning

confidence: 86%

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

Gamsızkan¹,

Yılmaz²,

Büyükbabanı³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…There are fewer studies on SLNB from Asian countries compared with Western countries. The studies performed in Asian countries have revealed rates of SLN positivity ranging 15.5–41.8% . The rate of SLN positivity in this study was 42.2%, which is relatively high compared with previously obtained values.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of melanoma in Asian countries is lower than that in Western countries. There are fewer studies on SLNB from Asian countries [11][12][13][14][15][16][17] compared with Western countries. The studies performed in Asian countries have revealed rates of SLN positivity ranging 15.5-41.8%.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Since the first report by Morton et al 1 in 1992, numerous studies have proven the prognostic value of sentinel lymph node biopsy (SLNB), 2,[5][6][7][8][9] and the American Joint Committee on Cancer has recommended SLNB for patients with certain types of melanoma, such as thick (>1 mm) or ulcerated melanomas. 10 However, compared with Western countries, in Asian countries, where melanoma is relatively uncommon, few studies on the use of SLNB [11][12][13][14][15][16][17] have been conducted. In addition to differences in prevalence, Asians and Caucasians differ in terms of Clark's subtype.…”

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confidence: 99%

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Sentinel lymph node biopsy for 102 patients with primary cutaneous melanoma at a single Japanese institute

Otsuka

Kaji

Iwatsuki

et al. 2015

The Journal of Dermatology

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Sentinel lymph node biopsy (SLNB) is a widely accepted standard procedure for patients with clinically localized melanoma. Melanoma prevalence and Clark's subtype differ between Asians and Caucasians. Here, we evaluated our experience on SLNB for cutaneous melanoma in a Japanese population. SLNB was performed for patients with melanoma between July 2000 and June 2014. We retrospectively analyzed 102 patients regarding association of clinicopathological features with sentinel lymph node (SLN) status, melanoma‐specific survival (MSS) and disease‐free survival (DFS). A positive SLN was significantly associated with primary Breslow thickness. Compared with 43 patients with negative SLN, 59 patients with positive SLN had significantly shorter MSS (5‐year survival rate, 94.3% vs 63.2%; P = 0.0002) and DFS (5‐year survival rate, 92.7% vs 63.4%; P = 0.0004). According to our subgroup analyses, nine patients with positive non‐SLN had significantly shorter MSS compared with 32 patients with negative non‐SLN (5‐year survival rate, 32.4% vs 68.5%; P = 0.0273). The survival of 51 Japanese patients with acral lentiginous melanoma (ALM) was not inferior to the survival of patients with other Clark's subtype. Breslow thickness is an important factor for both MSS and DFS, and the status of SLN is the most predictive prognostic factor in Japanese patients with clinically localized melanomas, as in case of Caucasians. Features of ALM may be different between Asians and Caucasians.

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“…The association between positive SLN status and DFS was not analyzed. Another recent multicenter, large-scale study in Japan showed that SLN metastasis is a prognostic factor for both OS and DFS20. In accordance with these results, our study showed that patients with positive SLN status had a higher local recurrence rate (42.9% vs.10.0%, p =0.042) and tended to show a higher rate of distant metastasis (50.0% vs. 20.0%, p =0.135) than those with negative SLN status.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Survival Analysis and Clinical Follow-Up in Acral Lentiginous Malignant Melanoma Undergoing Sentinel Lymph Node Biopsy in Korean Patients

et al. 2014

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BackgroundIn cutaneous malignant melanoma (MM) with clinically uninvolved regional lymph nodes, sentinel lymph node (SLN) status is the most powerful indicator of both overall survival (OS) and disease-free survival (DFS). However, no studies on the long-term survival and clinical follow-up of Korean patients with acral lentiginous MM (ALM) undergoing SLN biopsy (SLNB) have been published.ObjectiveThe purpose of this study was to investigate the clinical prognosis and long-term survival of Korean patients with ALM according to SLN status.MethodsThirty-four ALM patients undergoing SLNB were included in this study. We evaluated clinical and histopathological follow-up data such as the stage of disease, treatment, recurrence, and metastasis, and analyzed OS and DFS according to SLN status.ResultsThe median follow-up time was 60.5 months (range 3~127 months). Positive SLNs were noted in 14 patients (41.2%). Patients with negative SLNs had better OS and DFS than those with positive SLNs (p<0.05). Increased Breslow thickness was associated with short OS and DFS (p<0.05), and female patients showed better DFS than male patients (p<0.05).ConclusionTo our knowledge, this is the first study on the long-term survival and clinical follow-up of patients undergoing SLNB for ALM in Korea. Our findings show that SLN status is an important prognostic factor for predicting OS and DFS.

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Prediction of additional lymph node positivity and clinical outcome of micrometastases in sentinel lymph nodes in cutaneous melanoma: A multi‐institutional study of 450 patients in Japan

Cited by 23 publications

References 35 publications

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

Sentinel lymph node biopsy for 102 patients with primary cutaneous melanoma at a single Japanese institute

Long-Term Survival Analysis and Clinical Follow-Up in Acral Lentiginous Malignant Melanoma Undergoing Sentinel Lymph Node Biopsy in Korean Patients

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