Prediction of cervical lymph node metastasis in patients with papillary thyroid cancer using combined conventional ultrasound, strain elastography, and acoustic radiation force impulse (ARFI) elastography

Xu, Jun; Xu, Xiao; Xu, Hui; Zhang, Yi Feng; Guo, Le Hang; Liu, Lin Na; Liu, Chang; Bo, Xiao W; Qu, Shen; Xing, Mingzhao; Li, Xiayu

doi:10.1007/s00330-015-4088-2

Cited by 67 publications

(62 citation statements)

References 43 publications

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“…SWS ratio was figured out by mean intra-nodular and extra-nodular SWS values. After excluding other factors such as movement or breath of patient, inappropriate ROI placement or improper precompression, the measurement results of “X.XX m/s” (either extremely soft or extremely hard) were displaced by 0 m/s (the cystic portion) or 8.4 m/s (the solid portion) as suggested by previous studies [22, 25]. …”

Section: Methodsmentioning

confidence: 87%

Risk stratification of thyroid nodules with Bethesda category III results on fine-needle aspiration cytology: The additional value of acoustic radiation force impulse elastography

Zhao

et al. 2016

Oncotarget

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To assess the value of conventional ultrasound, conventional strain elastography (CSE) and acoustic radiation force impulse (ARFI) elastography in differentiating likelihood of malignancy for Bethesda category III thyroid nodules. 103 thyroid nodules with Bethesda category III results on fine-needle aspiration cytology (FNAC) in 103 patients were included and all were pathologically confirmed after surgery. Conventional ultrasound, CSE and ARFI elastography including ARFI imaging and point shear wave speed (SWS) measurement were performed. Univariate and multivariate analyses were performed to identify the independent factors associated with malignancy. Area under the receiver operating characteristic curve (Az) was calculated to assess the diagnostic performance. Pathologically, 65 nodules were benign and 38 were malignant. Significant differences were found between benign and malignant nodules in ARFI. The cut-off points were ARFI imaging grade ≥ 4, SWS > 2.94 m/s and SWS ratio > 1.09, respectively. ARFI imaging (Az: 0.861) had the highest diagnostic performance to differentiate malignant from benign nodules, following by conventional ultrasound (Az: 0.606 - 0.744), CSE (Az: 0.660) and point SWS measurement (Az: 0.725 - 0.735). Multivariate logistic regression analysis showed that ARFI imaging grade ≥ 4 was the most significant independent predictor. The combination of ARFI imaging with point SWS measurement significantly improved the specificity (100% vs. 80.0%) and positive predictive value (100 % vs. 72.9%) in comparison with ARFI imaging alone. ARFI elastography is a useful tool in differentiating malignant from benign thyroid nodules with Bethesda category III results on FNAC.

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Section: Methodsmentioning

confidence: 87%

Risk stratification of thyroid nodules with Bethesda category III results on fine-needle aspiration cytology: The additional value of acoustic radiation force impulse elastography

Zhao

et al. 2016

Oncotarget

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“…However, our study has clinical significance by showing the benefit of 3D US compared with 2D US in the off-site evaluation after scanning, which might often occur in clinical situations. Second, we did not compare the 2D and 3D US for the evaluation of cervical lymphadenopathy, which is important in treatment planning and prognostic evaluation for thyroid cancer patients [31]. Hence, further studies in these directions are needed.…”

Section: Discussionmentioning

confidence: 99%

Off-site evaluation of three-dimensional ultrasound for the diagnosis of thyroid nodules: comparison with two-dimensional ultrasound

Kim

Choi

et al. 2016

Eur Radiol

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“…SWE will continue being the problem solver not only with the risk categorization using the shear wave velocity (SWV) values, but with many other aspects, i.e. comparing the SWE color coded maps of the normal parenchyma and the lesions [21] Sometimes the stiffness of the nodule can be graded using the VTI maps and the risk of malignancy and a possible lymph node metastasis can be predicted [22]. SWE can sometimes present more useful and problem-solving data in the categorization of the thyroid nodules with nondiagnostic grey-scale US findings.…”

Section: Ultrasonographymentioning

confidence: 99%

Current Radiological Approach in Thyroid Nodules

Yıldırım¹,

Alış²,

Şirolu³

et al. 2017

JCT

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The aim of this paper is to review the radiological evaluation of thyroid nodules detected with ultrasonography (US), thoroughly and in harmony with the clinical-endocrinological-surgical management. In this review, we tried to summarize the radiological evaluation of nodules detected in the thyroid in compliance with recently published and accepted guidelines, including the most advanced sonographic protocols, emphasizing the indications of crosssectional imaging when needed. In this review important aspects were demonstrated with tables, illustrations and take-home points and technical aspects were emphasized with images and diagrams. We believe that this review, which is concluded with an extensive summary with the support of most recent sources, is an up-to-date and comprehensive evaluation of the broad spectrum of thyroid nodule radiology. We think that the management of any kind of nodule that can be encountered during the US examination can be done successfully by going through the paths described in the pictures, tables and texts in this article.

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Prediction of cervical lymph node metastasis in patients with papillary thyroid cancer using combined conventional ultrasound, strain elastography, and acoustic radiation force impulse (ARFI) elastography

Cited by 67 publications

References 43 publications

Risk stratification of thyroid nodules with Bethesda category III results on fine-needle aspiration cytology: The additional value of acoustic radiation force impulse elastography

Risk stratification of thyroid nodules with Bethesda category III results on fine-needle aspiration cytology: The additional value of acoustic radiation force impulse elastography

Off-site evaluation of three-dimensional ultrasound for the diagnosis of thyroid nodules: comparison with two-dimensional ultrasound

Current Radiological Approach in Thyroid Nodules

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