“…In addition, the highly conserved cysteine residue in the ECL2 gets the position number 45.50, and amino acids located in the ECL2 are numbered in relation to Cys 45.50 . According to the prediction by Heo et al, the binding pocket is located between helices 3, 4, 5, and 6, and adenine is predicted to mainly interact with five amino acids: Phe110 3.24 (Phe83 [15], TMD3), Asn115 3.29 (Asn88 [15], TMD3), Asn173 4.60 (Asn146 [15], TMD4), Leu201 5.47 (Leu174 [15], TMD5), and His252 6.54 (His225 [15], TMD6), of which the two asparagine residues Asn 3.29 and Asn4.60 were hypothesized to be most important [15].…”