Predictive and prognostic value of inflammatory markers in locally advanced rectal cancer (PILLAR) – A multicentric analysis by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Study Group

Chiloiro, G.; Romano, Angela; Mariani, Silvia; Macchia, G.; Giannarelli, Diana; Caravatta, L.; Franco, Pierfrancesco; Boldrini, Luca; Arcelli, A.; Bacigalupo, Almalina; Belgioia, Liliana; Fontana, Antonella; Meldolesi, Elisa; Montesi, Giampaolo; Niespolo, R.M.; Palazzari, Elisa; Piva, Cristina; Valentini, Vincenzo; Gambacorta, Maria Antonietta

doi:10.1016/j.ctro.2023.100579

Cited by 11 publications

(6 citation statements)

References 46 publications

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“…Nowadays, chemotherapy is administrated before or after radiotherapy, and the sequence of radiotherapy, chemotherapy and surgery has been extensively explored. In general, INCT combined with CRT is a preferred method since it is associated with better compliance and fewer acute adverse reactions (13,50,52). In our study, all patients underwent two cycles of induction chemotherapy and fluorouracil-based chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 91%

Chemoradiotherapy in Locally Advanced Rectal Cancer Patients

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Discussionmentioning

confidence: 91%

Chemoradiotherapy in Locally Advanced Rectal Cancer Patients

2024

Frontiers Research Topics

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“…Similar results were obtained in previous publications, highlighting the potential predictive role of body composition assessment and SMI in LARC patients undergoing RT [31] , [32] . One of the possible explications of this finding could be the relationship between lower muscle mass and the elevated inflammatory index, detrimental to clinical and survival outcomes [33] , [34] . In the CAO/ARO/AIO-04 clinical trial, performed on 1236 rectal cancer-affected patients, Fokas et al showed that underweight patients had worse DFS, was associated with worse TME quality and higher incidence of acute organ toxicity, and showed higher T stage and reduced ECOG performance status, giving the plausible explanation that underweight is linked to inflammation, a hallmark of cancer with muscle wasting and fat depletion induced by increased levels of cytokines [35] .…”

Section: Discussionmentioning

confidence: 99%

Impact of body composition parameters on radiation therapy compliance in locally advanced rectal cancer: A retrospective observational analysis

Chiloiro,

Cintoni,

Palombaro

et al. 2024

Clinical and Translational Radiation Oncology

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“…However, the present study suffers from some limitations: firstly, it is a retrospective analysis with a wide accrual period; consequently, there is a lack of information about the others prognostic factors such as EMVI status, the presence of tumoral deposits, mucinous histotype and biochemical parameters. Added value could come from combining radiomic information with that derived from lymphocyte profiles or other blood parameters, which have shown predictive power for radiotherapy response in other settings [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Delta Radiomic Analysis of Mesorectum to Predict Treatment Response and Prognosis in Locally Advanced Rectal Cancer

Chiloiro

Cusumano

Romano

et al. 2023

Cancers

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Background: The aim of this study is to evaluate the delta radiomics approach based on mesorectal radiomic features to develop a model for predicting pathological complete response (pCR) and 2-year disease-free survival (2yDFS) in locally advanced rectal cancer (LARC) patients undergoing neoadjuvant chemoradiotherapy (nCRT). Methods: Pre- and post-nCRT MRIs of LARC patients treated at a single institution from May 2008 to November 2016 were retrospectively collected. Radiomic features were extracted from the GTV and mesorectum. The Wilcoxon–Mann–Whitney test and area under the receiver operating characteristic curve (AUC) were used to evaluate the performance of the features in predicting pCR and 2yDFS. Results: Out of 203 LARC patients, a total of 565 variables were evaluated. The best performing pCR prediction model was based on two GTV features with an AUC of 0.80 in the training set and 0.69 in the validation set. The best performing 2yDFS prediction model was based on one GTV and two mesorectal features with an AUC of 0.79 in the training set and 0.70 in the validation set. Conclusions: The results of this study suggest a possible role for delta radiomics based on mesorectal features in the prediction of 2yDFS in patients with LARC.

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Predictive and prognostic value of inflammatory markers in locally advanced rectal cancer (PILLAR) – A multicentric analysis by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Study Group

Cited by 11 publications

References 46 publications

Chemoradiotherapy in Locally Advanced Rectal Cancer Patients

Chemoradiotherapy in Locally Advanced Rectal Cancer Patients

Impact of body composition parameters on radiation therapy compliance in locally advanced rectal cancer: A retrospective observational analysis

Delta Radiomic Analysis of Mesorectum to Predict Treatment Response and Prognosis in Locally Advanced Rectal Cancer

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