Polym. Chem.
 2024
DOI: 10.1039/d4py00196f
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Predictive design of multimonomeric polyelectrolytes enables lung-specific gene delivery

Jeffrey M. Ting,
John D. Fisher,
Tyler Conyers
et al.

Abstract: We present a class of programmable polymer nanoparticles capable of intravenous pDNA delivery with ~350,000-fold enhancement of specificity to the lung by qPCR in mice. Molecular level insight of these...

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