Predictive effect of Bayes discrimination in the level of serum protein factors and cognitive dysfunction in schizophrenia

Huang, Zhengyuan; Kang, Mei; Li, Guangyu; Xiong, Peng; Chen, Hongxu; Kang, Lin; Li, Shan; Lu, Cailian; Li, Qianqian; Bai, Meiyan

doi:10.1016/j.jpsychires.2022.05.004

Cited by 14 publications

(15 citation statements)

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“…The depressive symptoms and impulsive behaviors of schizophrenic patients are seen in multiple disease stages. Studies have shown that the BDNF level in the peripheral blood of schizophrenic patients was declined [ 16 ]. There was decreased PI3K expression in the animal and cell models of schizophrenia [ 40 , 41 ], down-regulated PI3K mRNA expression and increased AKT mRNA expression in the peripheral blood of schizophrenic patients [ 42 , 43 ], and increased susceptibility of schizophrenic symptoms in AKT3-deficient mice [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, considering some differential pathophysiological changes in different disease phases and possible drug & treatment effects, it is critical to supplement the relevant studies. Our previous study has preliminarily proven the diagnostic values of several peripheral serum protein factors for schizophrenia [ 16 , 17 ]. The pathophysiological mechanism of schizophrenia may be associated with serum protein factors concerning neurotrophy, synaptic transmission, and cellular signaling.…”

Section: Introductionmentioning

confidence: 99%

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Study on correlations of BDNF, PI3K, AKT and CREB levels with depressive emotion and impulsive behaviors in drug-naïve patients with first-episode schizophrenia

Kang

et al. 2023

BMC Psychiatry

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Background The pathogenesis of schizophrenia is still unknown. Nearly a half of schizophrenic patients have depressive symptoms and even some impulsive behaviors. The definite diagnosis of schizophrenia is an immense challenge. Molecular biology plays an essential role in the research on the pathogenesis of schizophrenia. Objective This study aims to analyze the correlations of serum protein factor levels with depressive emotion and impulsive behaviors in drug-naïve patients with first-episode schizophrenia. Methods Seventy drug-naïve patients with first-episode schizophrenia and sixty-nine healthy volunteers from the health check center in the same period participated in this study. In both the patient group and control group, brain-derived neurotrophic factor (BDNF), phosphatidylin-ositol-3-kinase (PI3K), protein kinase B (AKT), and cAMP-response element binding protein (CREB) levels in the peripheral blood were tested by enzyme-linked immunosorbent assay (ELISA). The depressive emotion and impulsive behaviors were evaluated with Chinese versions of the Calgary Depression Scale for Schizophrenia (CDSS) and Short UPPS-P Impulsive Behavior Scale (S-UPPS-P), respectively. Results The serum levels of BDNF, PI3K, and CREB in the patient group were lower than those in the control group, while AKT level, total CDSS score and total S-UPPS-P score were all higher. In the patient group, total CDSS score, and total S-UPPS-P score were both correlated negatively with BDNF, PI3K, and CREB levels but positively with AKT level, and the lack-of-premeditation (PR) sub-scale score was not significantly correlated with BDNF, PI3K, AKT, and CREB levels. Conclusion Our study results showed that the peripheral blood levels of BDNF, PI3K, AKT, and CREB in drug-naïve patients with first-episode schizophrenia were significantly different from those in the control group. The levels of these serum protein factors are promising biomarkers to predict schizophrenic depression and impulsive behaviors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study on correlations of BDNF, PI3K, AKT and CREB levels with depressive emotion and impulsive behaviors in drug-naïve patients with first-episode schizophrenia

Kang

et al. 2023

BMC Psychiatry

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“…A total of 28 articles were used to write the systematic review. Of these articles, 20 focused on astrocyte analysis ( Hagenauer et al, 2018 ; O’Donovan et al, 2018 ; López-González et al, 2019 ; Amoah et al, 2020 ; Chan et al, 2020 ; Karpiński et al, 2020 ; Kindler et al, 2020 ; Rodrigues-Amorim et al, 2020 ; Zhang et al, 2020 ; Corley et al, 2021 ; Jeon et al, 2021 ; Ranganathan et al, 2021 ; Shimamoto-Mitsuyama et al, 2021 ; Uranova et al, 2021 ; Di Biase et al, 2022 ; Endres et al, 2022 ; Huang et al, 2022 ; Pinjari et al, 2022 ; Schmitt et al, 2022 ; Zong et al, 2023 ), and 18 focused on microglia analysis ( Hagenauer et al, 2018 ; López-González et al, 2019 ; Adorjan et al, 2020 ; Karpiński et al, 2020 ; Kindler et al, 2020 ; Petrasch-Parwez et al, 2020 ; Uranova et al, 2020 , 2021 ; Zhang et al, 2020 ; Corley et al, 2021 ; Hill et al, 2021 ; Jiang et al, 2021 ; Shimamoto-Mitsuyama et al, 2021 ; Di Biase et al, 2022 ; Vikhreva and Uranova, 2022 ; Jenkins et al, 2023 ; Yu et al, 2023 ; Zong et al, 2023 ). Importantly, on the total of the researches concerning astroglia and microglia measures, 10 evaluated both aspects.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding in vivo neurobiological and morphological analyses of astrocytes, the literature screening produced 6 studies ( Rodrigues-Amorim et al, 2020 ; Jeon et al, 2021 ; Ranganathan et al, 2021 ; Endres et al, 2022 ; Huang et al, 2022 ; Pinjari et al, 2022 ), 3 of whom evaluated the astrocytes by performing analyses of the glial fibrillary acidic protein (GFAP) marker, a structural component of astrocytes cytoskeleton ( Rodrigues-Amorim et al, 2020 ; Ranganathan et al, 2021 ; Huang et al, 2022 ). GFAP is the protein of intermediate filament in astrocytes and it is commonly used as a hallmark of reactive astrocytes, contributing to the neuroplasticity by dynamic processes, such as the morphology of dendrites, synapsis formation, and neuronal migration and differentiation ( Moehle et al, 2012 ; Kapitein and Hoogenraad, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

“…Through Western Blot analyses, the authors also examined CD9 exosomal membrane marker and GFAP level, showing a higher concentration of exosomal GFAP in the plasma from patients compared to healthy controls. Furthermore, Huang et al (2022) measured the levels of GFAP and S100β—another astrocytic marker—as well as IL-6, nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), and TNF-α in the peripheral blood of patients with schizophrenia and healthy controls. Contrary to previous studies, their results showed no significant difference in GFAP concentration between groups, whereas a higher concentration of S100β, IL-6, NGF, and TNF-α was detected in patients’ group compared to control group.…”

Section: Resultsmentioning

confidence: 99%

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The role of glial cells in mental illness: a systematic review on astroglia and microglia as potential players in schizophrenia and its cognitive and emotional aspects

Laricchiuta,

Papi,

Decandia

et al. 2024

Front. Cell. Neurosci.

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Schizophrenia is a complex and severe mental disorder that affects approximately 1% of the global population. It is characterized by a wide range of symptoms, including delusions, hallucinations, disorganized speech and behavior, and cognitive impairment. Recent research has suggested that the immune system dysregulation may play a significant role in the pathogenesis of schizophrenia, and glial cells, such as astroglia and microglia known to be involved in neuroinflammation and immune regulation, have emerged as potential players in this process. The aim of this systematic review is to summarize the glial hallmarks of schizophrenia, choosing as cellular candidate the astroglia and microglia, and focusing also on disease-associated psychological (cognitive and emotional) changes. We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched PubMed, Scopus, and Web of Science for articles that investigated the differences in astroglia and microglia in patients with schizophrenia, published in the last 5 years. The present systematic review indicates that changes in the density, morphology, and functioning of astroglia and microglia may be involved in the development of schizophrenia. The glial alterations may contribute to the pathogenesis of schizophrenia by dysregulating neurotransmission and immune responses, worsening cognitive capabilities. The complex interplay of astroglial and microglial activation, genetic/epigenetic variations, and cognitive assessments underscores the intricate relationship between biological mechanisms, symptomatology, and cognitive functioning in schizophrenia.

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Correlation study of brain-derived neurotrophic factor, EEG γ activity and cognitive function in first-episode schizophrenia

Li,

Lu,

et al. 2023

Brain Research

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Predictive effect of Bayes discrimination in the level of serum protein factors and cognitive dysfunction in schizophrenia

Cited by 14 publications

References 44 publications

Study on correlations of BDNF, PI3K, AKT and CREB levels with depressive emotion and impulsive behaviors in drug-naïve patients with first-episode schizophrenia

Study on correlations of BDNF, PI3K, AKT and CREB levels with depressive emotion and impulsive behaviors in drug-naïve patients with first-episode schizophrenia

The role of glial cells in mental illness: a systematic review on astroglia and microglia as potential players in schizophrenia and its cognitive and emotional aspects

Correlation study of brain-derived neurotrophic factor, EEG γ activity and cognitive function in first-episode schizophrenia

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