Predictive factors and prognostic value for status epilepticus in newborns

High Effectiveness of Midazolam and Lidocaine in the Treatment of Acute Neonatal Seizures

“…16,28 In addition, the definitions of good response and seizure burden differ markedly from study to study. 2,8,14,[17][18][19][20]29,30 The midazolam dosage regimen used in this study also differed significantly from those used in previous studies. To date, owing to the dreaded side effects, most studies have used lower doses than those used in this study.…”

“…Our results are difficult to compare with those of previous studies that have evaluated the therapeutic response to different ASM. Some studies included preterm and full-term infants, 14 – 16 others included clinical seizures, 17 some studies were performed using aEEG, 2 , 18 – 20 others used intermittent 15 or continuous cEEG, 21 – 24 and only some using continuous video-EEG. 25 , 26 Continuous video-EEG monitoring is the gold standard for neonatal seizure diagnosis, 27 and the limitations of aEEG for neonatal monitoring are multiple.…”

“… 16 , 28 In addition, the definitions of good response and seizure burden differ markedly from study to study. 2 , 8 , 14 , 17 – 20 , 29 , 30 …”