Predictive Factors for Altered Quality of Life in Patients with Type 2 Diabetes Mellitus

Albai, Oana; Braha, Adina; Timar, Bogdan; Timar, Romulus

doi:10.3390/jcm13154389

Cited by 2 publications

References 50 publications

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Effects of an exercise intervention (Tai Chi) on diabetic peripheral neuropathy in a mHealth model

Fang,

Chen,

Han

et al. 2024

Preprint

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Background: E-health interventions can promote physical activity among adults in the short term, but there is still a lack of evidence on long-term effects.We conducted a randomized controlled trial to assess the effectiveness as well as the sustainability of the intervention. Our primary aim of this exercise intervention was to improve overall health-related quality of life （HRQoL）, and our secondary aims were to improve nerve conduction indices and glycemia. Material & methods: The study design was a parallel randomized controlled trial. The participants were randomly paired and assigned to control and intervention groups (each consisting of 50 members). Patients assigned to the intervention group received online instruction in Tai Chi exercises three times a week for three months under the guidance of a physical therapist. The intervention group was asked to use the Tencent conference application, which provided online video instruction on Tai Chi exercises. Participants in the control group received a written Tai Chi exercise program and recommendations on a sheet of paper. The primary outcome was a Change in HRQoL in the intervention group over 6 months as measured by the PCS index score. Secondary outcomes included changes in SF-36v2, NRS, PSQI, motor nerve conduction index, blood glucose, and biochemical indices. Results: When comparing the primary outcomes at 6 months, we found that there was a significant difference in PCS scores (mean difference 4.33 [95% CI 2.03,5.87]; p = 0.01). Conclusion: Web-based exercise therapy for patients may help improve exercise therapy's effectiveness in treating DPN. In this exploratory study, the exercise group consistently trended better than the conventional group for most endpoints.

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Effects of an exercise intervention (Tai Chi) on diabetic peripheral neuropathy in a mHealth model

Fang,

Chen,

Han

et al. 2024

Preprint

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Efficacy and Safety of Agomelatine in Depressed Patients with Diabetes: A Systematic Review and Meta-Analysis

Gędek,

Modrzejewski,

Materna

et al. 2024

IJMS

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Major depressive disorder (MDD) and diabetes mellitus (DM) remain among the most prevalent diseases and the most significant challenges faced by medicine in the 21st century. The frequent co-occurrence and bidirectional relationship between the two conditions necessitates the identification of treatment strategies that benefit both. The purpose of this study was to systematically review and meta-analyze data on the efficacy and safety of agomelatine (AGO) in the treatment of patients with depression with comorbid diabetes to explore its potential mechanism of action in both diseases and its impact on diabetic parameters. Following PRISMA guidelines, a total of 11 studies were identified, both preclinical and clinical trials. Agomelatine has shown great potential as a treatment option for patients with diabetes and comorbid depression and anxiety. In addition to improving depressive and anxiety symptoms, it is also beneficial in glycemic control. A meta-analysis demonstrated a statistically significant reduction in glycated hemoglobin (HbA1C) and fasting blood glucose (FBG) levels following AGO administration over a period of 8–16 weeks. The administration of agomelatine was found to result in a significantly greater reduction in HbA1C than that observed with the selective serotonin reuptake inhibitor (SSRI) medications (namely fluoxetine, sertraline, and paroxetine) during 12–16 weeks of therapy. Furthermore, AGO has been found to be at least as effective as SSRIs in reducing depressive symptoms and more effective than SSRIs in reducing anxiety symptoms. The safety of such treatment is similar to SSRIs; no severe adverse events were reported, and the incidence of some side effects, such as insomnia and sexual dysfunction, are even less often reported. Particularly promising is also its potential action in improving some diabetic complications reported in preclinical trials. This might be through mechanisms involving the reduction in oxidative stress, anti-inflammatory effects, and potentially noradrenergic or NMDA receptor modulation. Further clinical studies on larger sample sizes, as well as elucidating its mechanisms of action, especially in the context of diabetic complications, are needed. Research should also focus on identifying the patient subpopulations most likely to benefit from agomelatine treatment.

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Predictive Factors for Altered Quality of Life in Patients with Type 2 Diabetes Mellitus

Cited by 2 publications

References 50 publications

Effects of an exercise intervention (Tai Chi) on diabetic peripheral neuropathy in a mHealth model

Effects of an exercise intervention (Tai Chi) on diabetic peripheral neuropathy in a mHealth model

Efficacy and Safety of Agomelatine in Depressed Patients with Diabetes: A Systematic Review and Meta-Analysis

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