Predictive factors for birth weight of newborns of mothers with gestational diabetes mellitus

Silva, Sara de Oliveira Corrêa da; Saunders, Cláudia; Zajdenverg, Lenita; Moreira, Luciana Novaes; Heidelmann, Sonaly Petronilho; Pereira, Ariane Cristine dos Santos; Padilha, Patrícia de Carvalho; Infantil, Grupo de Pesquisa em Saúde Materna e

doi:10.1016/j.diabres.2018.01.032

Cited by 9 publications

(9 citation statements)

References 27 publications

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“…A review from 2018 concluded that an excessive BW is triggered by excessive, pre-pregnancy BMI (≥25 kg/m 2 ) and gestational diabetes. 6 Moreover, Silva et al 7 underlined that the predictors for BW were pre-gestational BMI and postprandial glucose blood levels in mothers during the third trimester of pregnancy. Thus, Farah et al 8 showed that GWG influences BW with a value of 8.4% outcome variance, underlining that BW was correlated with smoking, parity, and GesAge.…”

Section: Discussionmentioning

confidence: 99%

The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)

et al. 2019

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BackgroundThe aim of this study was to evaluate the direct effects of matrix metalloproteinase (MMP9 rs17577, MMP9 rs17576) and alfa 2 adrenergic receptor (ADRA2A rs553668) gene polymorphisms investigated in mothers and their newborns on maternal weight gain (MWG) during pregnancy and the newborn’s birth weight (BW), taking into account the presence of other related factors.MethodsWe performed a cross-sectional study in 197 mother–newborn pairs in an Obstetrics Gynecology Clinic, in order to evaluate the demographic and anthropometric parameters, and gene polymorphism.ResultsBW was positively correlated with maternal age (p = 0.021) and the educational level (p = 0.002), and negatively correlated with smoking status in pregnant women (p < 0.001). The MMP9 rs17577 variant genotypes in mothers led to a lower BW (p = 0.049). The mothers with a variant genotype of ADRA2A rs553668 gene polymorphism had newborns with a higher BW (p = 0.030). MWG and gestational age (GesAge) influenced BW (p < 0.05). We noticed that newborns’ variant genotype of MMP9 rs17577 was related to a significant increase in BW (p = 0.010), while the newborns who carried the variant genotype of MMP9 rs17576 expressed a negative correlation, decreasing the BW (p = 0.032).ConclusionOur study emphasizes the role of MMP9 rs17577, MMP9 rs17576, and ADRA2A rs553668 SNPs in BW determinism.

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Section: Discussionmentioning

confidence: 99%

The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)

et al. 2019

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“…Compared to other studies with Brazilian pregnant women (58,59) , in the present study, the average intake of calcium, potassium and magnesium was higher for both groups, while sodium intake was lower, suggesting that prenatal nutritional care has a positive impact on diet. Previous studies of women who developed GDM have identified the protective role of regular prenatal nutritional care with a minimum of six appointments on foetal macrosomia and glycaemic profile (21,60) .…”

Section: Discussionmentioning

confidence: 99%

Effect of the Dietary Approaches to Stop Hypertension (DASH) diet on the development of preeclampsia and metabolic outcomes in pregnant women with pre-existing diabetes mellitus: a randomised, controlled, single-blind trial

et al. 2023

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Preeclampsia (PE) affects up to five times more women with pre-existing diabetes mellitus (PDM) than women without it. The present study aimed to identify the effect of the DASH diet on PE incidence (primary outcome) and blood pressure, glycated haemoglobin (GH), serum lipids, glutathione peroxidase (GP), C-reactive protein (CRP – secondary outcomes) in pregnant with PDM. This randomised, controlled, single-blind trial studied sixty-eight pregnant women with PDM throughout prenatal care until delivery (18 weeks) at a public maternity hospital, Brazil. The standard diet group (SDG) received a diet containing 45–65 % carbohydrates, 15–20 % protein and 25–30 % lipids. The DASH diet group (DDG) received the adapted DASH diet with a similar macronutrient distribution, but with a higher concentration of fibres, unsaturated fats, calcium, magnesium and potassium as well as lower saturated fat. Student's t, Mann–Whitney U and the Chi-square tests were used to compare outcomes. PE incidence was 22⋅9 % in the SDG and 12⋅1 % in the DDG (P = 0⋅25). GP levels significantly increased in the DDG (intra-group analysis; mean difference = 1588 [CI 181, 2994], P = 0⋅03) and tended to be different from the variation in the SDG (mean difference = −29⋅5 [CI −1305; 1⋅365]; v. DDG: 1588 [CI 181; 2994], P = 0⋅09). GH levels decreased significantly and similarly between groups (SDG: −0⋅61 [CI −0⋅26, −0⋅96], P = 0⋅00) v. DDG: −1⋅1 [CI −0⋅57, −1⋅62], P = 0⋅00). There was no evidence of a difference in PE incidence at the end of the intervention between the two diets. The DASH diet seems to favour PE-related biochemical markers.

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“…However, majority of those studies only focused on a certain time point of pregnancy and it was hard to reveal the real effect on birth weight. Secondly, we did all analyses based on different pre-pregnancy BMI levels of subjects since the BMI before pregnancy has an important influence on the pregnancy outcome of women with GDM, including neonatal birth weight [ 37 , 38 ]. However, some limitations of our study have to be considered.…”

Section: Discussionmentioning

confidence: 99%

The associations of ferritin, serum lipid and plasma glucose levels across pregnancy in women with gestational diabetes mellitus and newborn birth weight

et al. 2023

BMC Pregnancy Childbirth

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Background Women with gestational diabetes mellitus (GDM) are at greater risk of abnormal birth weight. Since the level of biochemical indicators could often affect the intrauterine growth and development of the fetus, it is of great practical significance to understand the changes of biochemical levels across pregnancy in women with GDM and to find out the indicators that play an important role in predicting birth weight. Methods The data source of this study was from the Xi'an Longitudinal Mother–Child Cohort study (XAMC), in which women with GDM with normal and high pre-pregnancy body mass index (BMI) and their newborns between January 1st and March 31st in 2018 were included. The data of ferritin, serum lipid profile and fasting plasma glucose (FPG) of mothers in the three trimesters of pregnancy, as well as birth weight of newborns were all collected from medical records. Multiple linear regression and multivariate logistic regression analyses were used to explore the association of the biochemical indexes and birth weight. A P value < 0.05 was considered statistically significant. Results A total of 782 mother-infant pairs were finally included and divided into normal weight group (NG) (n = 530, 67.8%) and overweight/obesity group (OG) (n = 252, 32.2%) according to maternal pre-pregnancy BMI. The level of ferritin in both NG and OG decreased during pregnancy (P for trend < 0.001 for all), whereas the levels of total cholesterol (TC), high density cholesterol (HDL-C), low density cholesterol (LDL-C) and triglycerides (TG) all showed an upward trend (P for trend < 0.05 for all). The levels of FPG in the two groups remained in a relatively stable during the whole pregnancy even though it was higher in OG during the 2nd and 3rd trimesters, whilst HbAlc levels in NG women increased (P for trend = 0.043) during pregnancy. Meanwhile, the risk of macrosomia and large-for-gestational-age (LGA) increased with the increase of FPG level (P for trend < 0.05). Multivariate logistic regression analyses results showed that only FPG level in the 3rd trimester was correlated with birth weight, with birth weight increased by 44.9 g for each SD increase in FPG level. Conclusion Maternal FPG in the 3rd trimester is an independent predictor of newborn birth weight, and a higher level of that is associated with an increased risk of macrosomia and LGA.

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Predictive factors for birth weight of newborns of mothers with gestational diabetes mellitus

Cited by 9 publications

References 27 publications

The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)

The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)

Effect of the Dietary Approaches to Stop Hypertension (DASH) diet on the development of preeclampsia and metabolic outcomes in pregnant women with pre-existing diabetes mellitus: a randomised, controlled, single-blind trial

The associations of ferritin, serum lipid and plasma glucose levels across pregnancy in women with gestational diabetes mellitus and newborn birth weight

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