Predictive factors for successful sperm retrieval by microdissection testicular sperm extraction in men with nonobstructive azoospermia and a history of cryptorchidism

Qin, Chao; Su, Shifeng; Chen, Xinglin; Wei, Yuang; Ren, Xiaohan; Zhang, Xu; Li, Guangyao; Lù, Zhongwen; Zhao, Dong

doi:10.4103/aja2021102

Cited by 13 publications

(7 citation statements)

References 40 publications

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“…1 a, the maximum and minimum values of Age (91 and 36) were collapsed to 100 and 0, respectively; HL and NHL in Pathology corresponded to 61 and 65, respectively; the presence or absence of Systemic therapy corresponded to 51 and 61, respectively; Localized/Regional and Distant in SEER Stage corresponded to 55 and 61, respectively; the presence or absence of Surgery corresponded to 61 and 52, respectively; Female and Male corresponded to 61 and 70, respectively; MCA and Poverty corresponded to 61 and 82, respectively; Unilateral and Bilateral corresponded to 61 and 75, respectively. The method of nomograms is based on the score corresponding to each predictor of a patient, summed to calculate the total score, and the risk value corresponding to the score of the total points is the probability of an event for a patient (dead for OS, dead from PAL for DSS and FGS) 16 . A patient with ID 50031326 is used as an example.…”

Section: Resultsmentioning

confidence: 99%

Development and validation of nomograms to predict survival of primary adrenal lymphoma: a population-based retrospective study

Sun,

Wang,

Yao

et al. 2023

Sci Rep

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While it is known that accurate evaluation of overall survival (OS) and disease-specific survival (DSS) for patients with primary adrenal lymphoma (PAL) can affect their prognosis, no stable and effective prediction model exists. This study aimed to develop prediction models to evaluate survival. This study enrolled 5448 patients with adrenal masses from the SEER Program. The influencing factors were selected using the least absolute shrinkage and selection operator regression model (LASSO) and Fine and Gray model (FGM). In addition, nomograms were constructed. Receiver operating characteristic curves and bootstrap self-sampling methods were used to verify the discrimination and consistency of the nomograms. The independent influencing factors for PAL survival were selected by LASSO and FGM, and three models were built: the OS, DSS, and FGS (DSS analysis by FGM) model. The areas under the curve and decision curve analyses indicated that the models were valid. This study developed survival prediction models to predict OS and DSS of patients with PAL. The FGS model was more accurate than the DSS model in the short term. Above all, these models should offer benefits to patients with PAL in terms of the treatment modality choice and survival evaluation.

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Section: Resultsmentioning

confidence: 99%

Development and validation of nomograms to predict survival of primary adrenal lymphoma: a population-based retrospective study

Sun,

Wang,

Yao

et al. 2023

Sci Rep

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“…There were several studies exploring the influencing factors of successful sperm retrieval, including a unilateral or bilateral cryptorchidism history, age at orchidopexy, testicular volume, and serum sexual hormone levels, while many views were controversial [ 29 – 32 ]. The logistics regression and ROC curve analyzes showed that orchidopexy age was a significant predictor to retrieve sperm, even though the predictive utility was not perfect enough probably due to an inadequate sample size.…”

Section: Discussionmentioning

confidence: 99%

Stepwise mini-incision microdissection testicular sperm extraction in NOA patients with a history of cryptorchidism: a case–control study

Xu,

Huang,

Yao

et al. 2023

Basic Clin. Androl.

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Background Although the orchiopexy is recommended for cryptorchidism to preserve male fertility, non-obstructive azoospermia (NOA) may occur in adulthood. Fortunately, a great many of azoospermic men may obtain sperm by microdissection testicular sperm extraction (mTESE). Due to the potential injuries caused by testicular diagnostic biopsy and vascular damage at the time of orchidopexy, minimal invasiveness is particularly important during mTESE, aims to reduce the surgical damage and avoids secondary testicular failure. This comparative study aims to investigate the efficacy of stepwise mini-incision mTESE technique by comparison with standard mTESE in the treatment of NOA patients with a history of cryptorchidism. Results A total of 73 mTESE procedures were divided into two groups: Group 1 included 37 cases performed by stepwise mini-incision mTESE, while Group 2 included 36 cases with standard mTESE. The overall sperm retrieval rate (SRR) in the two groups was 68.5% (50/73), with no significant difference in SRR between Group 1 (78.4%, 29/37) and Group 2 (58.3%, 21/36) (P = 0.1). In addition, 46.0% of the patients (17/37) obtained sperm in the first mini-incision step in Group 1, which was also equal to an overall SRR in Group 2 (58.3%, 21/36) (P = 0.3). The operation time in Group 1 (72.6 ± 33.9 min) was significantly shorter than that in Group 2 (90.4 ± 36.4 min) (P = 0.04). Patients with an orchidopexy age no more than 10 years old had a higher SRR (79.5%, 31/39) than others (55.9%, 19/34) (P = 0.03). There were no postoperative complications including wound infection, scrotal hematoma, persistent pain, and testicular atrophy during a follow-up period of at least 6 months. Conclusions In conclusion, our study suggests that the stepwise mini-incision mTESE could be a promising approach for sperm retrieval in NOA men with a history of cryptorchidism. While the technique may potentially reduce operation time and surgical invasiveness, further research is needed to validate these findings on a larger scale. The results also suggest that age at orchidopexy may affect SRR and have important implications for the management of cryptorchidism.

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“…By mapping the value of each factor to the "points" axis, the points for early death probability for each variable were obtained. The total points can be calculated by summing them up [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

A novel risk prediction nomogram for early death in patients with resected synchronous multiple primary colorectal cancer based on the SEER database

Zhang

Zhao

et al. 2023

Int J Colorectal Dis

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Background Synchronous multiple primary colorectal cancer (SMPCC) involves the simultaneous occurrence of 2 or more independent primary malignant tumors in the colon or rectum. Although SMPCC is rare, it results in a higher incidence of postoperative complications and mortality compared to patients with single primary colorectal cancer (SPCRC). Methods The clinical factors and survival outcomes of SMPCC patients registered on the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2017 were extracted. The patients were divided into the training and validation cohorts using a ratio of 7:3. Univariate and multivariate logistic regression analyses were used to identify the independent risk factors for early death. The performance of the nomogram was evaluated using the concordance index (C-index), calibration curves, and the area under the curve (AUC) of a receiver operating characteristics curve (ROC). A decision curve analysis (DCA) was used to evaluate the clinical utility of the nomogram and standard TNM system. Results A total of 4386 SMPCC patients were enrolled in the study and randomly assigned to the training (n = 3070) and validation (n = 1316) cohorts. The multivariate logistic analysis identified age, chemotherapy, radiotherapy, T stage, N stage, and M stage as independent risk factors for all-cause and cancer-specific early death. The marital status was associated with all-cause early death, and the tumor grade was associated with cancer-specific early death. In the training cohort, the nomogram achieved a C-index of 0.808 (95% CI, 0.784–0.832) and 0.843 (95% CI, 0.816–0.870) for all-cause and cancer-specific early death, respectively. Following validation, the C-index was 0.797 (95% CI, 0.758–0.837) for all-cause early death and 0.832 (95% CI, 0.789–0.875) for cancer-specific early death. The ROC and calibration curves indicated that the model had good stability and reliability. The DCA showed that the nomogram had a better clinical net value than the TNM staging system. Conclusion Our nomogram can provide a simple and accurate tool for clinicians to predict the risk of early death in SMPCC patients undergoing surgery and could be used to optimize the treatment according to the patient's needs.

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Predictive factors for successful sperm retrieval by microdissection testicular sperm extraction in men with nonobstructive azoospermia and a history of cryptorchidism

Cited by 13 publications

References 40 publications

Development and validation of nomograms to predict survival of primary adrenal lymphoma: a population-based retrospective study

Development and validation of nomograms to predict survival of primary adrenal lymphoma: a population-based retrospective study

Stepwise mini-incision microdissection testicular sperm extraction in NOA patients with a history of cryptorchidism: a case–control study

A novel risk prediction nomogram for early death in patients with resected synchronous multiple primary colorectal cancer based on the SEER database

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