Predictive factors for the presence of malignant transformation of pelvic endometriosis

Kadan, Yfat; Fiascone, Stephen; McCourt, Carolyn K.; Raker, Christina; Granai, C.O.; Steinhoff, Margaret M.; Moore, Richard G.

doi:10.1016/j.ejogrb.2014.11.029

Cited by 25 publications

(17 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a recent case–control study by Kadan et al (42 cases/96 controls) age and solid complexity were significantly associated with ovarian cancer arising in an endometriotic cyst (OR 2.17; 95% CI 1.29–3.63, p = 0.003 and OR 23.72; 95% CI 4.07–138.11, p < 0.0001, respectively) in the multivariate analysis (Table ). Regarding age, being ≥49 years at diagnosis of endometriosis was associated with ovarian malignancy (specificity 80.6%; 95% CI 62.5–92.5%, and sensitivity 82.9%; 95% CI 67.9–92.8%) (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Only one of three studies found a significant association between postmenopausal status and ovarian cancer; however, this study did not adjust for age, leaving the possibility that the increased risk could be a function of age and not menopause (Table ).…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasonographic findings of solid components in an ovarian cyst, symptomatic or not, are known to strongly indicate malignancy among the general population of women . The study by Kadan et al confirms that this also applies for women with endometriomas (Table ).…”

Section: Discussionmentioning

confidence: 99%

“…Two studies, including the best designed study, did not find a significant association between exogenous hyperestrogenism (hormone replacement therapy) and EOC among women with endometriosis . Regarding endogenous hyperestrogenism (high BMI) Kadan et al and Zanetta et al found no significant association in relation to ovarian cancer risk (Table ). However, after pooling women with unopposed estrogen (hormone replacement therapy) or BMI > 27 kg/m 2 , Zanetta et al found a significant increase in risk of ovarian cancer (Table ).…”

Section: Discussionmentioning

confidence: 99%

“…Finally, four of eight studies (10,24,25,29) relied on self-reported or clinically verified/non-surgical diagnosis of endometriosis, both of which may be highly impacted by misclassification (36). Four studies (9,26,28,35) included (mainly) surgical diagnosis of endometriosis (Table 1), but could be temporally impacted by incidental observation of endometriosis concurrent with ovarian cancer discovery.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Risk factors of epithelial ovarian carcinomas among women with endometriosis: a systematic review

Thomsen

Schnack

Buchardi

et al. 2016

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

Introduction. The objective of this review was to evaluate the published literature on epidemiologic risk factors for epithelial ovarian cancer among women with a diagnosis of endometriosis. Material and methods. A systematic literature search was conducted in PubMed and Scopus. Studies comparing epidemiologic risk factors of epithelial ovarian cancer among women with endometriosis were included. A quality assessment was conducted using the Newcastle-Ottawa Scale. Results. Eight of 794 articles met the inclusion criteria. A lower risk of epithelial ovarian cancer was observed in women with documented complete surgical excision of endometriotic tissue and suggested among women with unilateral oophorectomy. The use of oral contraceptives (≥10 years) may be associated with a lower risk of epithelial ovarian cancer among women with endometriosis, whereas older age at endometriosis diagnosis (≥45 years, pre-or postmenopausal), nulliparity, hyperestrogenism (endogenous or exogenous), premenopausal status at endometriosis diagnosis, solid compartments as well as larger size of endometrioma (≥9 cm in diameter at endometriosis diagnosis) were all associated with an increased risk of ovarian cancer. Conclusions. A subgroup of women with endometriosis characterized by endometriosis observed through surgery or imaging after the age of 45 years, nulliparity, postmenopausal status at endometriosis diagnosis, larger size of endometrioma (>9 cm) at endometriosis diagnosis, hyperestrogenism (endogenous or exogenous) and/or cysts with solid compartments may have an elevated risk of epithelial ovarian cancer. However, due to the limited number and size of studies in this area we cannot draw definitive conclusions. Further research into a risk factor profile among women with endometriosis is needed before clear recommendations can be made.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%