Predictive factors for triple-negative breast carcinoma

Abstract

Objective: To determine the clinicopathologic factors and Ki67 expression predicting triple-negative breast cancer (TNBC). Subject and method: A descriptive study on 169 patients with breast cancer at the 108 Military Central Hospital from October 2015 to September 2020. The status of estrogen receptor (ER), progesteron receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki67 expression were examined by immunochemistry. Result: The mean age of the patients was 53.8 ± 12.2 years. The rate of tumor size larger than 2cm was 54.4% (92/169). The percentage of cases with tumor grade 2 was highest at 64.5% (109/169). The rate of axillary lymph node metastasis was 37.9%. TNBC accounted for 16.6%. The statistically significant correlation was observed between TNBC and location, tumor size, histological grade and Ki67 ≥ 14%. Conclusion: Our study suggested that the right side, histological grade 3 and Ki67 ≥ 14% were independent predictive factor of TNBC.