Predictive Factors for Well-being in Advanced Cancer Patients Referred for Palliative Radiotherapy

Lien, Karen; Zeng, Liang; Zhang, L.; Nguyen, Janet; Giovanni, Julia Di; Popović, Marko; Jamani, Rehana; Cramarossa, Gemma; Culleton, Shaelyn; Chow, Edward

doi:10.1016/j.clon.2012.01.004

Cited by 29 publications

(32 citation statements)

References 33 publications

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“…11 Many have proposed that pain may share a common biological mechanism with depression. [12][13][14][15][16] Indeed, studies have begun to explore inflammation as a biological mechanism that may underlie pain and depressive symptoms in cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Depressive Symptoms among Cancer Patients in a Philippine Tertiary Hospital: Prevalence, Factors, and Influence on Health-Related Quality of Life

Que

Ortin

Gonzalez‐Suarez

et al. 2013

Journal of Palliative Medicine

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Section: Discussionmentioning

confidence: 99%

Depressive Symptoms among Cancer Patients in a Philippine Tertiary Hospital: Prevalence, Factors, and Influence on Health-Related Quality of Life

Que

Ortin

Gonzalez‐Suarez

et al. 2013

Journal of Palliative Medicine

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“…(1-3) Since painful bone metastases have a major impact on quality of life (QoL) in patients with advanced cancer (4,5), reducing pain is likely to improve QoL. Although a few studies showed that radiotherapy for painful bone metastases contributes to improvement of QoL, no thorough studies have been published focusing on the course of QoL after radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life in Relation to Pain Response to Radiation Therapy for Painful Bone Metastases

Westhoff

Graeff

Monninkhof

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

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“…Although reduction of pain is the main treatment goal, it is also important to focus on quality of life (QoL) [4]. Painful bone metastases have a negative impact on the QoL of patients [5,6]. Studies show that radiotherapy stabilizes or improves QoL [7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

et al. 2017

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Background: Psychological distress (PD) has a major impact on quality of life. We studied the incidence of PD before and after radiotherapy for painful bone metastases. Furthermore, we aimed to identify factors predictive for PD. Methods: Between 1996 and 1998, the Dutch Bone Metastasis Study included 1157 patients with painful bone metastases. Patients were randomized between two fractionation schedules. The study showed a pain response of 74% in both groups. Patients filled out weekly questionnaires for 13 weeks, then monthly for two years. The questionnaires included a subscale for PD on the Rotterdam Symptom Checklist. We used generalized estimating equations and multivariable logistic regression analyses. Results: At baseline, 290 patients (27%) had a high level of PD. For the entire group, the level of PD remained constant over time. The majority of patients with a low level of PD at baseline remained at a low level during follow-up. In patients with a high level of PD at baseline, the mean level of PD decreased after treatment and stabilized around the cutoff level. Female patients, higher age, worse performance, lower pain score and worse self-reported QoL were associated with an increased chance of PD, although the model showed moderate discriminative power. Conclusions: A substantial proportion of patients had a high level of PD before and after radiotherapy for painful bone metastases. Most patients who reported high levels of PD when referred for palliative radiotherapy remained at high levels thereafter. Therefore, screening of PD prior to treatment seems appropriate, in order to select patients requiring intervention.

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Predictive Factors for Well-being in Advanced Cancer Patients Referred for Palliative Radiotherapy

Cited by 29 publications

References 33 publications

Depressive Symptoms among Cancer Patients in a Philippine Tertiary Hospital: Prevalence, Factors, and Influence on Health-Related Quality of Life

Depressive Symptoms among Cancer Patients in a Philippine Tertiary Hospital: Prevalence, Factors, and Influence on Health-Related Quality of Life

Quality of Life in Relation to Pain Response to Radiation Therapy for Painful Bone Metastases

Screening for psychological distress before radiotherapy for painful bone metastases may be useful to identify patients with high levels of distress

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